The timing of gamma irradiation and its effect on c<scp>ell‐free</scp> and m<scp>icrovesicle‐bound</scp> hemoglobin. The <scp>BEST</scp> collaborative study

William, Nishaka; Bicahlo, Beatriz; Hansen, Arild E.; Korte, Dirk de; Acker, Jason P.

doi:10.1111/trf.16809

Cited by 3 publications

(3 citation statements)

References 23 publications

(44 reference statements)

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“…The impact of the timing of irradiation is controversial. Although sREV release did not significantly vary with timing of irradiation in one report [20 ▪ ], both X and gamma irradiation induced a higher sREV generation in PRBCs that were older at the time of irradiation or were stored for longer postirradiation periods in another study [21].…”

Section: Generation and Characterization Of Stored Red Cell Derived E...mentioning

confidence: 91%

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Red cell extracellular vesicles and coagulation activation pathways

Noubouossie,

Key

2023

Current Opinion in Hematology

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Purpose of review Packed red blood cells (PRBCs) are the most commonly transfused blood products. Preparation of PRBCs requires blood collection from donors, processing, and storage prior to transfusion to recipients. Stored red blood cells (RBCs) undergo structural and metabolic changes collectively known as the storage lesion. RBC extracellular vesicles (sREVs) are released in PRBC units during storage, and are transfused along with intact RBCs into recipients. For several decades, extracellular vesicles have been the focus of intense research, leading to the discovery of a wide variety of endogenous biological properties that may impact numerous physiologic and/or pathologic pathways. Recent findings This study reviews the characteristics of extracellular vesicles present in PRBC units and the impact of prestorage and pretransfusion processing, as well as storage conditions, on their generation. Importantly, we discuss recently described interactions of sREVs with coagulation pathways and related interplay with inflammatory pathways in vitro and in vivo using animal models. Summary Extracellular vesicles present in stored PRBC units are capable of activating coagulation pathways. However, it remains unclear whether this affects clinical outcomes in recipients of PRBC units. Further understanding of these pathways and their relationship to any adverse outcomes may yield novel strategies to mitigate complications of blood transfusion.

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Section: Generation and Characterization Of Stored Red Cell Derived E...mentioning

confidence: 91%

“…PRBC units may be irradiated to prevent graft-versus-host disease in high-risk recipient populations. In addition to increasing the hemolysis rate, both X and gamma irradiation may similarly increase sREV release [19][20][21]. The impact of the timing of irradiation is controversial.…”

Section: Influence Of Pretransfusion Processingmentioning

confidence: 99%

Red cell extracellular vesicles and coagulation activation pathways

Noubouossie,

Key

2023

Current Opinion in Hematology

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“…Biochemical compounds and biological complexes in transfused blood products can lead to non‐infectious adverse effects in susceptible recipients 47 . Therefore, understanding mechanisms for how blood products, and compounds found therein interact with recipient cells and organ systems; and use of novel strategies to prevent occurrence of the “wrong” product being transfused into the “right” recipient or the “right” product transfused to the “wrong” recipient are important to advancing blood safety 48,49 . Research to define exposure limits and standards for concentrations of potentially harmful compounds and methods to improve blood safety by reducing errors in all steps of the transfusion process are still needed.…”

Section: Research Prioritiesmentioning

confidence: 99%

Proceedings of the 2022 NHLBI and OASH state of the science in transfusion medicine symposium

et al. 2023

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Background: State of the Science (SoS) meetings are used to define and highlight important unanswered scientific questions. The National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, and the Office of the Assistant Secretary for Health (OASH), Department of Health and Human Services held a virtual SoS in transfusion medicine (TM) symposium. Study Design and Methods:In advance of the symposium, six multidisciplinary working groups (WG) convened to define research priorities in the areas of: blood donors and the supply, optimizing transfusion outcomes for recipients, emerging infections, mechanistic aspects of components and transfusion, new computational methods in transfusion science, and impact of health disparities on donors and recipients. The overall objective was to identify key basic, translational, and clinical research questions that will help to increase and diversify the volunteer donor pool, ensure safe and effective

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