The timing of administration of exogenous glucocorticoid affects 24 hour growth hormone secretion in children

Wolthers, Ole D.; Ramshanker, Nilani; Heuck, Carsten; Frystyk, Jan

doi:10.1016/j.ghir.2017.06.004

Cited by 5 publications

(5 citation statements)

References 29 publications

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“…The IGF-1 levels are significantly decreased in dexamethason -treated mice at Day 7. This result was in accordance with the report that dexamethason decreased serum and liver IGF-1 and maintained liver IGF-1 mRNA in parenterally fed rats (Wolthers et al, 2017). IGF-1 has been considered as a major regulator of growth and development as well as wound healing and has direct actions on fibroblasts, endothelial and epithelial cells (Wicke et al, 2000).…”

Section: Discussionsupporting

confidence: 92%

“…In addition, Insulin-like growth factor-I (IGF-I) can be helpful on wound healing (Cieszkowski et al, 2017) which associated with proliferation, differentiation as well as wound healing process (Reckenbeil et al, 2017). Likewise, IGF-1 can be suppressed by glucocorticoids (Wolthers et al, 2017). Chromium (Cr) is an essential trace element and nutrient for humans and animals, it functions as a cofactor for insulin when in the trivalent oxidation state (Cr 3+ ).…”

Section: Introductionmentioning

confidence: 99%

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Trivalent Chromium Restore Dexamethasone-Induced Attenuation Effect of Insulin-Like Growth Factor-1 and Promote Skin Wound Healing in Mice

Hsieh¹

2019

PVJ

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This study was conducted to investigate the effects of Cr 3+ on wound healing in mice. A total of 96 male C57BL6/J mice were randomly assigned to four groups (n=24/group). These mice were divided 4 groups and treated by normal saline, chromium chloride (CrCl3), dexamethasone (Dex) as well as combination of CrCl3 and Dex, respectively. Six mice of each group were sacrificed on day 7, 14, and 21 after skin incision. Skin wound area were measured and collected for histology evaluation, tissue of organs was collected for Cr 3+ concentration determination as well as blood collected for serum IGF-I concentrations determination. Delayed healing was found in Dex group, and an accelerated healing was observed in both Cr groups. In histology, the delayed inflammation process, reepithelization, granulation tissue formation as well as collagen deposition were observed in Dex groups. However, reversed detrimental effects of Dex were observed in Cr groups. The concentrations of IGF-1 in Dex groups revealed significant decrement compared to other groups, but Cr 3+ reversed this effect. Therefore, Cr 3+ accelerated wound healing in surgical wound model of mice through the regulation of hormone concentrations such as IGF-1, meanwhile, the effects could be more prominent when animal is under stress or treated by exogenous glucocorticoids. ©2019 PVJ. All rights reserved Key words:Dexamethasone Healing Insulin-like growth factor-1 Mice Trivalent chromium Wound To Cite This Article: Hsieh YT, Hsu TH, Wang HC, Chen KS and Lee WM, 2019. Trivalent chromium restore dexamethasone-induced attenuation effect of insulin-like growth factor-1 and promote skin wound healing in mice. Pak Vet J, 39(2): 199-204. http://dx.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Trivalent Chromium Restore Dexamethasone-Induced Attenuation Effect of Insulin-Like Growth Factor-1 and Promote Skin Wound Healing in Mice

Hsieh¹

2019

PVJ

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“…For patients who need to use GC, when the condition is stable, priority should be given to the treatment of local, short-term, low-dose and alternate-day administration, and short-acting GC with less inhibitory effect on bone growth should be selected as far as possible ( 89 ). A clinical study found that ( 90 ), compared with short-term administration once a day in the morning, taking 5 mg prednisolone once in the evening can inhibit 24-hour growth hormone secretion. Therefore, compared with taking exogenous GC at night, taking in the morning has less effect on growth rate.…”

Section: Therapeutic Strategies For Skeletal Growth Inhibition Caused...mentioning

confidence: 99%

Glucocorticoid induced bone disorders in children: Research progress in treatment mechanisms

Hua

Huang

et al. 2023

Front. Endocrinol.

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Long-term or supra-physiological dose of glucocorticoid (GC) application in clinic can lead to impaired bone growth and osteoporosis. The side effects of GC on the skeletal system are particularly serious in growing children, potentially causing growth retardation or even osteoporotic fractures. Children’s bone growth is dependent on endochondral ossification of growth plate chondrocytes, and excessive GC can hinder the development of growth plate and longitudinal bone growth. Despite the availability of drugs for treating osteoporosis, they have failed to effectively prevent or treat longitudinal bone growth and development disorders caused by GCs. As of now, there is no specific drug to mitigate these severe side effects. Traditional Chinese Medicine shows potential as an alternative to the current treatments by eliminating the side effects of GC. In summary, this article comprehensively reviews the research frontiers concerning growth and development disorders resulting from supra-physiological levels of GC and discusses the future research and treatment directions for optimizing steroid therapy. This article may also provide theoretical and experimental insight into the research and development of novel drugs to prevent GC-related side effects.

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“…138 Additional circadian considerations for GH treatment were highlighted in a small study examining prednisone administration to 10 healthy children, which reported that evening administration suppressed GH secretion whereas morning administration did not. 139 It is also important to note that a common limitation of biomedical studies is a male bias and, as is the case with most physiological processes, there is a significant sex difference in human GH patterns. 140 Thus, future studies must consider both time of day and sex as biological variables to optimize GH treatment.…”

Section: Growth Hormonementioning

confidence: 99%

“…A study in 34 children undergoing GH therapy in the morning, afternoon, or evening, reported no differences among groups in growth, IGF‐1, or GH‐BP after 6 or 12 months of GH treatment 138 . Additional circadian considerations for GH treatment were highlighted in a small study examining prednisone administration to 10 healthy children, which reported that evening administration suppressed GH secretion whereas morning administration did not 139 . It is also important to note that a common limitation of biomedical studies is a male bias and, as is the case with most physiological processes, there is a significant sex difference in human GH patterns 140 .…”

Section: Endocrine Disordersmentioning

confidence: 99%

Circadian Variation in Efficacy of Medications

Walton

Walker

Bumgarner

et al. 2020

Clin Pharma and Therapeutics

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Although much has been learned about circadian clocks and rhythms over the past few decades, translation of this foundational science underlying the temporal regulation of physiology and behavior to clinical applications has been slow. Indeed, acceptance of the modern study of circadian rhythms has been blunted because the phenomenology of cyclic changes had to counteract the 20th century dogma of homeostasis in the biological sciences and medicine. We are providing this review of clinical data to highlight the emerging awareness of circadian variation in efficacy of medications for physicians, clinicians, and pharmacists. We are suggesting that gold‐standard double‐blind clinical studies should be conducted to determine the best time of day for optimal effectiveness of medications; also, we suggest that time of day should be tracked and reported as an important biological variable in ongoing clinical studies hereafter. Furthermore, we emphasize that time of day is, and should be considered, a key biological variable in research design similar to sex. In common with biomedical research data that have been historically strongly skewed toward the male sex, most pharmaceutical data have been skewed toward morning dosing without strong evidence that this is the optimal time of efficacy.

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The timing of administration of exogenous glucocorticoid affects 24 hour growth hormone secretion in children

Cited by 5 publications

References 29 publications

Trivalent Chromium Restore Dexamethasone-Induced Attenuation Effect of Insulin-Like Growth Factor-1 and Promote Skin Wound Healing in Mice

Trivalent Chromium Restore Dexamethasone-Induced Attenuation Effect of Insulin-Like Growth Factor-1 and Promote Skin Wound Healing in Mice

Glucocorticoid induced bone disorders in children: Research progress in treatment mechanisms

Circadian Variation in Efficacy of Medications

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