The time trends of cognitive impairment incidence among older Chinese people in the community: based on the CLHLS cohorts from 1998 to 2014

Gao, Mingyue; Kuang, Weihong; Qiu, Peiyuan; Wang, Huali; Lv, Xiaozhen; Yang, Min

doi:10.1093/ageing/afx038

Cited by 65 publications

(54 citation statements)

References 21 publications

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“…In addition, recent studies have reported trends in decreasing incidence of Alzheimer disease and other cognitive impairments since the late twentieth century, and researchers suggest that this results from increasing level of education and decreasing prevalence of cardiovascular comorbidities [53][54][55][56][57]. We also speculate that the introduction of anti-herpetic medications, for example, acyclovir [58], since the 1980s, could also contribute to this trend by decreasing the risk of dementia in HSV-infected patients.…”

Section: Discussionmentioning

confidence: 72%

Anti-herpetic Medications and Reduced Risk of Dementia in Patients with Herpes Simplex Virus Infections—a Nationwide, Population-Based Cohort Study in Taiwan

et al. 2018

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This retrospective cohort study is to investigate the association between herpes simplex virus (HSV) infections and dementia, and the effects of anti-herpetic medications on the risk involved, using Taiwan's National Health Insurance Research Database (NHIRD). We enrolled a total of 33,448 subjects, and identified 8362 with newly diagnosed HSV infections and 25,086 randomly selected sex- and age-matched controls without HSV infections in a ratio of 1:3, selected from January 1, to December 31, 2000. A multivariable Cox proportional hazards regression model was used to evaluate the risk of developing dementia in the HSV cohort. This analysis revealed an adjusted hazard ratio of 2.564 (95% CI: 2.351-2.795, P < 0.001) for the development of dementia in the HSV-infected cohort relative to the non-HSV cohort. Thus, patients with HSV infections may have a 2.56-fold increased risk of developing dementia. A risk reduction of dementia development in patients affected by HSV infections was found upon treatment with anti-herpetic medications (adjusted HR = 0.092 [95% CI 0.079-0.108], P < 0.001). The usage of anti-herpetic medications in the treatment of HSV infections was associated with a decreased risk of dementia. These findings could be a signal to clinicians caring for patients with HSV infections. Further research is, therefore, necessary to explore the underlying mechanism(s) of these associations.

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Section: Discussionmentioning

confidence: 72%

Anti-herpetic Medications and Reduced Risk of Dementia in Patients with Herpes Simplex Virus Infections—a Nationwide, Population-Based Cohort Study in Taiwan

et al. 2018

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“…The 1998 and 2000 waves only interviewed people in the oldest age group who were 80 years old and above. Since 2002, adults aged 60‐79 years old were also added to the survey 5 . As a mixed longitudinal study, the CLHLS recruited approximately one third of the subjects in each wave from those in the previous wave, while recruiting new subjects to match those lost to follow up in terms of age, gender and education.…”

Section: Methodsmentioning

confidence: 99%

“…The total score of the C‐MMSE is 30, and higher scores indicate better cognition. The C‐MMSE has been validated in previous study and is a widely accepted metric for cognitive function 5,16‐18 …”

Section: Methodsmentioning

confidence: 99%

“…There are several studies exploring incidence 5 and prevalence of cognitive impairment 4,6,7 in the general population as well as factors affecting cognitive functions. Another equally important area of research is identifying the trajectory of cognitive function among older adults over time and variables that can predict this trajectory.…”

Section: Introductionmentioning

confidence: 99%

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Heterogeneity in the dynamic change of cognitive function among older Chinese people: A growth mixture model

Qiu

Zeng

Kuang

et al. 2020

Int J Geriat Psychiatry

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Objectives Our aim is to distinguish different trajectories of cognitive change in Chinese geriatric population and identify risk factors for cognitive decline in each subpopulation. Methods We obtained data from five waves (2002, 2005, 2008, 2011, 2014) of the Chinese Longitudinal Health Longevity Survey, using the Chinese Mini‐Mental State Examination (C‐MMSE) as a proxy for cognitive function. We applied growth mixture modeling (GMM) to identify heterogeneous subpopulations and potential risk factors. Results Our sample included 3859 older adults, 1387 (48.7%) male and 1974 (51.2%) female with age range of 62 to 108 (average of 74.5) at initial survey. Using GMM and best fit statistics, we identified two distinct subgroups in respect to their longitudinal cognitive function: (a) cognitively stable (87.8%) group with 0.49 C‐MMSE points decline per 3 years, and (b) cognitively declining (12.2%) group with 6.03 C‐MMSE points decline per 3 years. Of note, cognitive activities were protective, and hearing and visual impairments were risk factors in both groups. Diabetes, hypertension, stroke and cardiovascular disease were associated with cognitive decline in the cognitively declining group. Physical activities, and intake of fresh vegetables, fruits, and fish products were protective in the cognitively stable group. Conclusions Using GMM, we identified heterogeneity in trajectories of cognitive change in older Chinese people. Moreover, we found risk factors specific to each subgroup, which should be considered in future studies.

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“…The results were very similar when the mean assignment was assessed to address missing data. 13,14 Valid samples that could be analysed, considering the integrity of the data collection, included 38 312 individuals from 58 945 observations. The total number of participants aged 80 years and older in the CLHLS was 8756, 10 986, 10 922, 10 606, 12 237 and 5368 for each survey year in 1998, 2000,2002,2005,2008 and 2012, respectively.…”

Section: Sampling and Data Sourcesmentioning

confidence: 99%

Socioeconomic disparities in leisure activities over the life course of the oldest‐old in China

2019

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Objective: To identify the socioeconomic factors leading to disparities in participation in leisure activities over the life course among Chinese oldest-old people. Methods: Data are from the Chinese Longitudinal Healthy Longevity Survey (CLHLS), a sample of adults aged 80 years or older in the period 1998-2012, featuring 38 312 individuals (58 945 observations). Results: The younger birth cohorts were found to have significantly higher levels of participation in leisure activities, with a non-linear decrease in age observed for oldest-old men and women. Higher participation levels were significantly related to higher education levels, economic independence and non-manual occupations before retirement among the Chinese oldest-old. Conclusions: Leisure activity participation has increased substantially in recent cohorts of Chinese oldest-olds. Those with lower socioeconomic status may represent a disadvantaged population in terms of participation in leisure activities over their life course.

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The time trends of cognitive impairment incidence among older Chinese people in the community: based on the CLHLS cohorts from 1998 to 2014

Abstract: the CI incidence among older Chinese people decreased from 1998 to 2014. Lower education level and less frequent health practices mentioned above were important risk factors in CI prevention.

Cited by 65 publications

References 21 publications

Anti-herpetic Medications and Reduced Risk of Dementia in Patients with Herpes Simplex Virus Infections—a Nationwide, Population-Based Cohort Study in Taiwan

Anti-herpetic Medications and Reduced Risk of Dementia in Patients with Herpes Simplex Virus Infections—a Nationwide, Population-Based Cohort Study in Taiwan

Heterogeneity in the dynamic change of cognitive function among older Chinese people: A growth mixture model

Socioeconomic disparities in leisure activities over the life course of the oldest‐old in China

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