The time to diagnosis in childhood lymphomas and other solid tumors

Çeçen, Emre; Güneş, Dilek; Mutafoglu, Kamer; Sarıalıoğlu, Faık; Olgun, Nur

doi:10.1002/pbc.23072

Cited by 27 publications

(54 citation statements)

References 36 publications

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“…The differences between the studies may be explained by the country and time period in which the studies were conducted. A study from western Turkey reported parental delay, physician delay and total delay as 3, 28, and 53 days, respectively [9]. In that study, physician delay and total delay were similar to those of our study, whereas parental delay was shorter.…”

Section: Discussionsupporting

confidence: 89%

“…Early diagnosis is a fundamental goal in oncology, and time to diagnosis is known to be among the important diagnostic factors [1,4,9,11]. In the published data, time to diagnosis has varied widely [1,3,6].…”

Section: Discussionmentioning

confidence: 98%

“…The second period, the time from the first medical consultation to diagnosis, was accepted as physician delay. These times were measured in days and designated as "short" when they were less than or equal to the median value or as "long" when they were greater than the median value [9].…”

Section: Methodsmentioning

confidence: 99%

“…With respect to childhood cancer in Turkey, the only data available on delayed diagnosis pertains to children living in western Turkey, and the data did not include leukemia [9]. The aim of this study was to determine the time to diagnosis and the risk factors for delayed diagnosis among pediatric cancer patients (leukemia, lymphoma, and solid tumors) treated in a dedicated pediatric oncology center in southeastern Turkey.…”

Section: Introductionmentioning

confidence: 98%

“…In childhood cancer, biology/anatomic site of the neoplasm, tumor stage, patient age, area of residence, and the health care system have been reported as the main factors related to delays in diagnosis [3,4,[7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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Delays in Diagnosis of Childhood Cancer in Southeastern Turkey and the Associated Factors

Araz

Güler

2014

Pediatric Hematology and Oncology

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In childhood cancer patients, early diagnosis may have an impact on survival that reduces the potential morbidity. This study aimed to identify the factors associated with delay in diagnosis in children with cancer in southeastern Turkey. The clinical records of 682 patients with childhood cancer were evaluated. Study variables were classified as factors related to the patient, their disease, and the health care system. The median parental delay, physician delay, and total delay were determined as 20, 23, and 60 days, respectively. There was a significant relationship between parental delay, physician delay, and total delay and age at diagnosis (P = .005, P = .008, and P = .004, respectively). Long parental delay was least frequent in children younger than 1 year (P = .001). Parental, physician, and total delay were longer in patients with solid tumors than in patients with leukemias (P = .007, P = .000, and P = .000, respectively). Patients with tumors of the genitalia had longer physician delay and total delay than patients with other solid tumors (P = .001 and P = .000, respectively). Patients with solid tumor and early-stage disease had longer physician delay and total delay (P = .016 and P = .013, respectively). According to the first physician contacted, long physician delay was less frequent among pediatricians (P = .003). Delayed diagnosis was associated with age, type/localization and stage of tumor, the first physician consulted, and area of residence. A sustained effort should be made to raise the level of awareness of childhood cancer among parents and to sensitize all physicians, especially those who treat pediatric patients infrequently, with regard to the warning signs of the disease.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 98%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Delays in Diagnosis of Childhood Cancer in Southeastern Turkey and the Associated Factors

Araz

Güler

2014

Pediatric Hematology and Oncology

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Duration of the pre‐diagnostic interval in medulloblastoma is subgroup dependent

Ramaswamy

Remke

Shih

et al. 2014

Pediatric Blood & Cancer

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The Sooner the Better? How Symptom Interval Correlates With Outcome in Children and Adolescents With Solid Tumors: Regression Tree Analysis of the Findings of a Prospective Study

Ferrari

Vullo

Giardiello

et al. 2015

Pediatr Blood Cancer

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Background. The potential impact of diagnostic delays on patients' outcomes is a debated issue in pediatric oncology and discordant results have been published so far. We attempted to tackle this issue by analyzing a prospective series of 351 consecutive children and adolescents with solid malignancies using innovative statistical tools. Methods. To address the nonlinear complexity of the association between symptom interval and overall survival (OS), a regression tree algorithm was constructed with sequential binary splitting rules and used to identify homogeneous patient groups vis-à-vis functional relationship between diagnostic delay and OS. Results. Three different groups were identified: group A, with localized disease and good prognosis (5-year OS 85.4%); group B, with locally or regionally advanced, or metastatic disease and intermediate prognosis (5-year OS 72.9%), including neuroblastoma, Wilms tumor, nonrhabdomyosarcoma soft tissue sarcoma, and germ cell tumor; and group C, with locally or regionally advanced, or metastatic disease and poor prognosis (5-year OS 45%), including brain tumors, rhabdomyosarcoma, and bone sarcoma. The functional relationship between symptom interval and mortality risk differed between the three subgroups, there being no association in group A (hazard ratio [HR]: 0.96), a positive linear association in group B (HR: 1.48), and a negative linear association in group C (HR: 0.61). Conclusions. Our analysis suggests that at least a subset of patients can benefit from an earlier diagnosis in terms of survival. For others, intrinsic aggressiveness may mask the potential effect of diagnostic delays. Based on these findings, early diagnosis should remain a goal for pediatric cancer patients. Pediatr Blood Cancer 2016;63:479-485. C 2015Wiley Periodicals, Inc.

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The time to diagnosis in childhood lymphomas and other solid tumors

Cited by 27 publications

References 36 publications

Delays in Diagnosis of Childhood Cancer in Southeastern Turkey and the Associated Factors

Delays in Diagnosis of Childhood Cancer in Southeastern Turkey and the Associated Factors

Duration of the pre‐diagnostic interval in medulloblastoma is subgroup dependent

The Sooner the Better? How Symptom Interval Correlates With Outcome in Children and Adolescents With Solid Tumors: Regression Tree Analysis of the Findings of a Prospective Study

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