The time of day that Etidronate is ingested does not influence its therapeutic effect in osteoporosis

Cook, Gary; Blake, Glen; Fogelman, Ignac

doi:10.1080/030097400750001824

Cited by 5 publications

(1 citation statement)

References 5 publications

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“…In a retrospective study of 110 patients with osteoporosis, Cook et al [54] assessed the influence of etidronate dosing regimen on treatment effectiveness, measured by changes in BMD. Patients were administered etidronate (1) after waking up, (2) at bedtime, or (3) during the day, and maintained 2 h fasting intervals before and after drug ingestion.…”

Section: Etidronatementioning

confidence: 99%

Optimal Dosing Regimen of Osteoporosis Drugs in Relation to Food Intake as the Key for the Enhancement of the Treatment Effectiveness—A Concise Literature Review

Wiesner

Szuta

Galanty

et al. 2021

Foods

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Bisphosphonates and selective estrogen receptor modulators (SERMs) represent the two most important groups of medications taken orally and employed in osteoporosis treatment. Effectiveness of the therapy may be affected by poor patient adherence, in particular, due to the inconvenient dosing regimen of oral bisphosphonates. With this review we aimed to assess the effects that food, beverages, and dietary supplements consumed during treatment, along with the dosing regimens, may have on pharmacokinetics and pharmacodynamics of oral drugs employed in treating osteoporosis; we also aimed to shape the recommendations valuable for professional patients’ counseling and education, to provide appropriate dosing regimens in order to improve adherence to the therapy. Food, beverages such as coffee, juices, and mineral water, as well as dietary supplements containing multivalent cations, e.g., calcium, magnesium, aluminium, iron, showed to have a deleterious effect on the bioavailability of all the investigated oral bisphosphonates, specifically alendronate, risedronate, ibandronate, minodronate, and etidronate. For risedronate, a delayed-release (DR) tablet was designed to solve the malabsorption problem in the presence of food, hence DR risedronate can be ingested following breakfast. For other oral bisphosphonates, the proper interval between drug and food, beverages, and dietary supplements intake should be maintained to minimize the risk of interactions. The effect of food on pharmacokinetic parameters of selective estrogen receptor modulators (SERMs) was found to be clinically irrelevant.

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Section: Etidronatementioning

confidence: 99%

Optimal Dosing Regimen of Osteoporosis Drugs in Relation to Food Intake as the Key for the Enhancement of the Treatment Effectiveness—A Concise Literature Review

Wiesner

Szuta

Galanty

et al. 2021

Foods

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Circadian Variation in Efficacy of Medications

Walton

Walker

Bumgarner

et al. 2020

Clin Pharma and Therapeutics

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Although much has been learned about circadian clocks and rhythms over the past few decades, translation of this foundational science underlying the temporal regulation of physiology and behavior to clinical applications has been slow. Indeed, acceptance of the modern study of circadian rhythms has been blunted because the phenomenology of cyclic changes had to counteract the 20th century dogma of homeostasis in the biological sciences and medicine. We are providing this review of clinical data to highlight the emerging awareness of circadian variation in efficacy of medications for physicians, clinicians, and pharmacists. We are suggesting that gold‐standard double‐blind clinical studies should be conducted to determine the best time of day for optimal effectiveness of medications; also, we suggest that time of day should be tracked and reported as an important biological variable in ongoing clinical studies hereafter. Furthermore, we emphasize that time of day is, and should be considered, a key biological variable in research design similar to sex. In common with biomedical research data that have been historically strongly skewed toward the male sex, most pharmaceutical data have been skewed toward morning dosing without strong evidence that this is the optimal time of efficacy.

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A minimum required number of studies of PBMD by DERA method in individual diagnosis of oteoporosis and monitoring of the skeleton state by the distal forearm

Аврунин¹,

Тихилов²,

Shoubniakov³

et al. 2009

ORTHOPAEDICS, TRAUMATOLOGY and PROSTHETICS

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The time of day that Etidronate is ingested does not influence its therapeutic effect in osteoporosis

Cited by 5 publications

References 5 publications

Optimal Dosing Regimen of Osteoporosis Drugs in Relation to Food Intake as the Key for the Enhancement of the Treatment Effectiveness—A Concise Literature Review

Optimal Dosing Regimen of Osteoporosis Drugs in Relation to Food Intake as the Key for the Enhancement of the Treatment Effectiveness—A Concise Literature Review

Circadian Variation in Efficacy of Medications

A minimum required number of studies of PBMD by DERA method in individual diagnosis of oteoporosis and monitoring of the skeleton state by the distal forearm

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