The Time Has Come for Physicians to Take Notice: The Impact of Psychosocial Stressors on the Heart

Figueredo, Vincent M.

doi:10.1016/j.amjmed.2009.05.001

Cited by 68 publications

(42 citation statements)

References 46 publications

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“…We recently showed that CBD also causes endothelium-dependent vasorelaxation in isolated human mesenteric arteries through CB 1 activation (11). Therefore, it is possible that the changes in hemodynamics brought about by CBD are mediated through CB 1 .…”

Section: Discussionmentioning

confidence: 99%

“…Epidemiological studies have shown a positive relationship between long-term stress and the development of cardiovascular disease (1). Factors like social isolation, low socioeconomic status, depression, stressful family and work life, and anxiety are associated with an increased risk of the development and accelerated progression of existing cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

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A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study

Jadoon¹,

Tan²,

O’Sullivan³

2017

JCI Insight

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study

Jadoon¹,

Tan²,

O’Sullivan³

2017

JCI Insight

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“…25 Psychological risk factors such as depressive symptoms, anxiety, and vital exhaustion may worsen or exacerbate the development of CVD through associated unhealthy behaviors and physiological responses (Table) that may lead to clinical consequences, including myocardial ischemia, threatening ventricular arrhythmias, vulnerable plaque, and increased thrombosis potential and inflammation. 26 -29 Recognizing this relationship offers an important potential target for cardiovascular risk reduction that requires testing in appropriately designed trials.…”

Section: Impact Of Psychosocial Risk Factors On Cardiovascular Diseasementioning

confidence: 99%

Recent Advances in Preventive Cardiology and Lifestyle Medicine

Franklin

Cushman

2011

Circulation

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M ultifactorial risk factor modification and control, especially interventions designed to reduce total cholesterol, systolic blood pressure, smoking prevalence, overweight/ obesity, diabetes mellitus, and physical inactivity, can have a profound and favorable impact on decreasing the incidence of initial and recurrent cardiovascular events. Between 1980 and 2000, mortality rates from coronary heart disease (CHD) fell by Ͼ40%. Using a previously validated statistical model (IMPACT), researchers attempted to determine how much of this decrease could be explained by the use of medical and surgical treatments as opposed to changes in risk factors among US adults aged 25 to 84 years. Approximately half of the decline in cardiovascular deaths was attributed to reductions in major risk factors (obesity and diabetes mellitus were notable exceptions), and approximately half was attributed to evidence-based medical therapies (eg, secondary prevention medications, rehabilitation, and initial treatments for acute myocardial infarction [AMI]). 1 In contrast, emergent and elective revascularization accounted for only 7% of the overall decline in deaths from CHD. Recently, similar results were reported in a Canadian study that evaluated the decrease in CHD mortality between 1994 and 2005. 2 Over the past decade, mortality rates from CHD and stroke in the United States decreased by Ͼ25% (Figure 1). 3 Although there were also impressive reductions in the prevalence of uncontrolled high blood pressure, elevated blood cholesterol, and, to a lesser extent, cigarette smoking, there was only limited impact on other risk factors, including increases in the prevalence of obesity and diabetes mellitus, and a small reduction in those not engaged in moderate or vigorous physical activity. 3 These indicators represent major challenges to achieving future goals for cardiovascular health promotion and disease reduction.In 2009, a task force representing numerous professional organizations/associations developed a Competence and Training Statement on the Prevention of Cardiovascular Disease. 4 More recently, the American Heart Association (AHA) released its bold new impact goal for the next 10 years, the 2020 Impact Goal: "to improve the cardiovascular health of all Americans by 20% while reducing deaths from cardiovascular diseases and stroke by 20%." 3 This 2020 goal has an innovative new element to improve clinically relevant health and behavioral factors. Cardiovascular health is defined in 3 categories of ideal, intermediate, and poor on the basis of 7 simple health factors and modifiable behaviors, as detailed in the My Life Check assessment tool at http://www.mylifecheck.heart.org.This review provides a compendium of important advances in preventive and lifestyle medicine during the past decade, including discussion of some emerging but unproven interventions (ie, the polypill) as well as the value of conducting large-scale randomized clinical trials rather than relying on biological hypotheses and observational data (ie, the homocy...

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“…[38][39][40][41][42] Anxiety and depression have been associated with increased risk of cardiovascular disease and are common in those with established cardiovascular disease; their added presence in established cardiovascular disease confers a poorer prognosis. 40,41,[43][44][45][46][47][48] There is a growing body of research which describes the mechanisms of mind-heart interactions. The autonomic nervous system is one of the principal components of the mindheart connection and is one of the fundamental links between thoughts and emotions and the heart.…”

mentioning

confidence: 99%