The time courses of excitatory and inhibitory synaptic actions

Curtis, D. R.; Eccles, John C.

doi:10.1113/jphysiol.1959.sp006159

Cited by 137 publications

(64 citation statements)

References 26 publications

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“…7;Curtis & Eccles, 1959). Such interaction shows a large degree of non-linearity of potential summation which fits with the idea that the monosynaptic EPSP, originating largely from dendritic sites, modifies the IPSP driving potential at sites of inhibitory conductance very close to the location of the recording electrode (the motoneurone soma; see Rall, 1964;Rall et al 1967).…”

Section: Discussionmentioning

confidence: 59%

“…6, upper right, the EPSP has been regarded as modified by an unchanged concurrent IPSP. This procedure is useful in order to visualize the degree of non-linearity in PSP interactions, although the premise on which it is based is not strictly correct because of the nature ofthe PSP generating mechanism (see Curtis & Eccles, 1959). This and all other studies of EPSP-IPSP interaction were done using K citrate filled micropipettes.…”

Section: Resultsmentioning

confidence: 99%

“…In cat alpha motoneurones, the location of the terminals of interneurones conveying group Ia inhibition from antagonist muscles has been assumed to be on or near the motoneurone soma (Curtis & Eccles, 1959). This conclusion has been based on the predictable behaviour of the disynaptic group Ia IPSP to current or anion injection into the motoneurone soma by way of a micropipette (Coombs et at.…”

Section: Introductionmentioning

confidence: 99%

“…This conclusion has been based on the predictable behaviour of the disynaptic group Ia IPSP to current or anion injection into the motoneurone soma by way of a micropipette (Coombs et at. 1955;Curtis & Eccles, 1959), and on the fact that the falling phase of the group I a IPSP closely resembles the time course of the membrane response obtained by injecting a constant current pulse into the cell soma (Curtis & Eccles 1959). A similar location has been assumed for the synaptic terminals of Renshaw interneurones which are responsible for the recurrent IPSP in motoneurones (Eccles, Fatt & Koketsu, 1954), since the effect of intracellular current and ion injection on the recurrent IPSP has been described to be about the same as that seen with the group Ia IPSP (Coombs et al 1955;Araki et al 1961).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Spatial synaptic distribution of recurrent and group Ia inhibitory systems in cat spinal motoneurones

Burke¹,

Fedina²,

Lundberg³

1971

The Journal of Physiology

109

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Ito & Oscarsson, 1961; Coombs, Eccles & Fatt, 1955).3. Studied with potassium chloride filled micropipettes. the reversal potential for the group I a IPSP was found to be different from that for the recurrent IPSP when the amount of Cl-diffusing or iontophoretically injected into the motoneurone was small. The amount of difference in reversal potential varied from cell to cell but when present the group I a IPSP reversed to a depolarizing potential more readily than the recurrent IPSP in all cases.4. Interaction between recurrent IPSPs and monosynaptic excitatory post-synaptic potentials (EPSPs) was also studied and the amount of nonlinearity of potential summation was measured.5. The results are consistent with the hypothesis that the terminations of Renshaw cells responsible for the recurrent IPSP are located largely on the proximal dendrites of motoneurones, while the terminations of the interneurones generating the group I a IPSP appear to be closer to or on the cell somata.

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Section: Discussionmentioning

confidence: 59%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Spatial synaptic distribution of recurrent and group Ia inhibitory systems in cat spinal motoneurones

Burke¹,

Fedina²,

Lundberg³

1971

The Journal of Physiology

109

View full text Add to dashboard Cite

show abstract

“…Tatsunosuke Araki (1926Araki ( -1985 and Takuzo Otani later described a Wheatstone bridge circuit, with which they were able to pass current through the same, single-barrelled electrode used for recording (Araki and Otani, 1955). Concurrent with this, Coombs and Curtis, the latter as part of his PhD research, had developed a similar bridge circuit for use with single and double electrodes (Coombs et al, 1956(Coombs et al, , 1959Curtis and Eccles, 1959). The first single electrode voltage-clamp circuit was not developed for another quarter century (Finkel and Redman, 1983a,b).…”

Section: Intracellular Recordings From Spinal Motoneurons (1949-1957)mentioning

confidence: 99%

Beginning at the end: Repetitive firing properties in the final common pathway

Brownstone

2006

Progress in Neurobiology

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Since the early 20th century, it has been recognized that motoneurons must fire repetitive trains of action potentials to produce muscle contraction. In 1932, Sir John Eccles, together with Hebbel Hoff, found that action potential spike trains in motor axons were produced by "rhythmic centres", which were within the motoneurons themselves. Two decades later, Eccles attended a Cold Spring Harbor Symposium in NY, USA entitled "The Neuron". Two of the many notable presentations at this symposium were juxtaposed: one by Eccles from the University of Otago, Dunedin, NZL, and the other by J. Walter Woodbury and Harry Patton from the University of Washington, Seattle, USA. Both presentations included data obtained using sharp microelectrodes to study the intracellularly recorded potentials of cat motoneurons. In this review, I discuss some of the events leading up to and surrounding this jointly accomplished advance and proceed to discussion of subsequent studies over 5+ decades that have made use of intracellular recordings from motoneurons to study their repetitive firing behavior. This begins with early descriptions of primary and secondary range firing, and continues to the discovery of dendritic persistent inward currents and their relation to plateau potentials, synaptic amplification, and motoneuronal firing. Following a brief description of the possible mechanisms underlying spike frequency adaptation, I discuss the modulation of repetitive firing properties during various motor behaviors. It has become increasingly clear that the central nervous system has exquisite control of the repetitive firing of motoneurons. Eccles' work laid the foundation for the present-day study of these processes.

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A Litre and a Half of Brains

OʼLeary¹

1962

Arch Neurol

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The time courses of excitatory and inhibitory synaptic actions

Cited by 137 publications

References 26 publications

Spatial synaptic distribution of recurrent and group Ia inhibitory systems in cat spinal motoneurones

Spatial synaptic distribution of recurrent and group Ia inhibitory systems in cat spinal motoneurones

Beginning at the end: Repetitive firing properties in the final common pathway

A Litre and a Half of Brains

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