The time course of phosphorylcreatine resynthesis during recovery of the quadriceps muscle in man

Harris, Roger C.; Edwards, R. H. T.; Hultman, E.; Nordesjö, Lars‐Olof; Nylind, B.; Sahlin, Kent

doi:10.1007/bf00585149

Cited by 411 publications

(296 citation statements)

References 31 publications

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“…The importance of oxygen availability for PCr resynthesis was first established by Harris, et al [20], who implemented a pneumatic cuff around the thigh (240 mmHg) for 6 minutes following a bout of isometric knee extension. As a result of the ischemic condition, PCr resynthesis was completely supressed.…”

Section: Hypoxia-mediated Challenges For Energetic Metabolismmentioning

confidence: 99%

Intermittent hypoxic resistance training: Is metabolic stress the key moderator?

Scott¹,

Slattery

Dascombe³

2015

Medical Hypotheses

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Traditionally, researchers and practitioners have manipulated acute resistance exercise variables to elicit the desired responses to training. However, recent research indicates that altering the muscular environment during resistance training, namely by implementing a hypoxic stimulus, can augment muscle hypertrophy and strength.Intermittent hypoxic resistance training (IHRT), whereby participants inspire hypoxic air during resistance training, has been previously demonstrated to increase muscle cross-sectional area and maximum strength by significantly greater amounts than the equivalent training in normoxia. However, some recent evidence has provided conflicting results, reporting that the use of systemic hypoxia during resistance training provided no added benefit. While the definitive mechanisms that may augment muscular responses to IHRT are not yet fully understood, an increased metabolic stress is thought to be important for moderating many downstream processes related to hypertrophy. It is likely that methodological differences between conflicting IHRT studies have resulted in different degrees of metabolic stress during training, particularly when considering the inter-set recovery intervals used. Given that the most fundamental physiological stresses resulting from hypoxia are disturbances to oxidative metabolism, it becomes apparent that resistance training may only benefit from additional hypoxia if the exercise is structured to elicit a strong metabolic response. We hypothesize that for IHRT to be more effective in producing muscular hypertrophy and increasing strength than the equivalent normoxic training, exercise should be performed with relatively brief inter-set recovery periods, with the aim of providing a potent metabolic stimulus to enhance anabolic responses.3

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Section: Hypoxia-mediated Challenges For Energetic Metabolismmentioning

confidence: 99%

Intermittent hypoxic resistance training: Is metabolic stress the key moderator?

Scott¹,

Slattery

Dascombe³

2015

Medical Hypotheses

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“…Peripheral muscle fatigue recovery is thought to vary with how much lactate the individual produces, as well as phosphorylcreatine resynthesis efficiency. 69 For most people, phosphorylcreatine resynthesis is believed to require roughly 2 minutes; significant strength deficits in lower extremity skeletal muscles such as the quadriceps have been found despite 1 minute of rest. 47,69 Perhaps as a result of afferent signals from fatigued muscles, central fatigue continues as long as peripheral fatigue exists.…”

Section: Kinematic and Kinetic Datamentioning

confidence: 99%

Hip-Abductor Fatigue and Single-Leg Landing Mechanics in Women Athletes

Patrek

Kernozek

Willson

et al. 2011

Journal of Athletic Training

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Context: Reduced hip-abductor strength and muscle activation may be associated with altered lower extremity mechanics, which are thought to increase the risk for anterior cruciate ligament injury. However, experimental evidence supporting this relationship is limited. Objective: To examine the changes in single-leg landing mechanics and gluteus medius recruitment that occur after a hip-abductor fatigue protocol. Design: Descriptive laboratory study. Patients or Other Participants: Twenty physically active women (age = 21.0 ± 1.3 years). Intervention(s): Participants were tested before (prefatigue) and after (postfatigue) a hip-abductor fatigue protocol consisting of repetitive side-lying hip abduction. Main Outcome Measure(s): Outcome measures included sagittal-plane and frontal-plane hip and knee kinematics at initial contact and at 60 milliseconds after initial contact during 5 single-leg landings from a height of 40 cm. Peak hip and knee sagittal-plane and frontal-plane joint moments during this time interval were also analyzed. Measures of gluteus medius activation, including latency, peak amplitude, and integrated signal, were recorded. Results: A small (<1°) increase in hip-abduction angle at initial contact and a small (<1°) decrease in knee-abduction (valgus) angle at 60 milliseconds after contact were observed in the postfatigue landing condition. No other kinematic changes were noted for the knee or hip at initial contact or at 60 milliseconds after initial contact. Peak external knee-adduction moment decreased 27% and peak hip adduction moment decreased 24% during the postfatigue landing condition. Gluteus medius activation was delayed after the protocol, but no difference in peak or integrated signal was seen during the landing trials. Conclusions: Changes observed during single-leg landings after hip-abductor fatigue were not generally considered unfavorable to the integrity of the anterior cruciate ligament. Further work may be justified to study the role of hip-abductor activation in protecting the knee during landing.

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“…8,9 The importance of O 2 in the resynthesis of PCr has been previously reported. [10][11][12][13] Anaerobic glycolysis ceases at the termination of peak exercise, and oxidative phosphorylation provides the ATP required for PCr recovery. 14 In cardiac diseases where the transportation and utilisation of O 2 in the contracting muscle is adversely affected, PCr recovery time has been reported to be prolonged following exercise, [15][16][17][18] whereas, a faster PCr recovery time has been demonstrated in healthy trained individuals.…”

Section: Introductionmentioning

confidence: 99%

Early oxygen uptake recovery following exercise testing in children with chronic chest diseases

Stevens

Oades

Armstrong

et al. 2009

Pediatric Pulmonology

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The time course of phosphorylcreatine resynthesis during recovery of the quadriceps muscle in man

Cited by 411 publications

References 31 publications

Intermittent hypoxic resistance training: Is metabolic stress the key moderator?

Intermittent hypoxic resistance training: Is metabolic stress the key moderator?

Hip-Abductor Fatigue and Single-Leg Landing Mechanics in Women Athletes

Early oxygen uptake recovery following exercise testing in children with chronic chest diseases

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