The thyroid registry: Clinical and hormonal characteristics of adult indian patients with hypothyroidism

Abstract

Objectives:Appropriate treatment of hypothyroidism requires accurate diagnosis. This registry aimed to study the disease profile and treatment paradigm in hypothyroid patients in India.Materials and Methods:We registered 1500 newly diagnosed, treatment-naïve, adult hypothyroid males and nonpregnant females across 33 centers and collected relevant data from medical records. The first analysis report on baseline data is presented here.Results:The mean age of the study population was 41.1 ± 14.01 years with a female to male ratio of 7:3. The most frequently reported symptoms and signs were fatigue (60.17%) and weight gain with poor appetite (36.22%). Menstrual abnormalities were reported in all women (n = 730) who had not attained menopause. Grades 1 and 2 goiter (as per the WHO) were observed in 15.41% and 3.27% patients, respectively. Comorbidities were reported in 545 patients (36.36%), type 2 diabetes mellitus being the most prevalent (13.54%) followed by hypertension (11.34%). Total serum thyroxine (T4) and thyroid-stimulating hormone (TSH) levels were assessed in 291 (19.47%) patients only. In majority of patients (81%), treatment was based on serum TSH levels alone. The dose of levothyroxine ranged from 12.5 to 375 mcg.Conclusions:Guidelines suggest a diagnosis of hypothyroidism based on TSH and T4 levels. However, most of the patients as observed in this registry received treatment with levothyroxine based on TSH levels alone, thus highlighting the need for awareness and scientific education among clinicians in India. The use of standard doses (100, 75, and 25 mcg) of levothyroxine may point toward empirical management practices.

Thyroid symptomatology across the spectrum of hypothyroidism and impact of levothyroxine supplementation in patients with severe primary hypothyroidism

“…In another multicentric thyroid registry, fatigue was the most commonly noted symptom. [11] In that study although 1500 patients were evaluated, biochemical status of hypothyroidism (serum TSH) was available only from 291 patients. [11] There was a drastic increase in the occurrence of menstrual irregularities with increase in severity of hypothyroidism in our study (73.62% in SPH vs. 16.25% in ScH).…”

“…[11] In that study although 1500 patients were evaluated, biochemical status of hypothyroidism (serum TSH) was available only from 291 patients. [11] There was a drastic increase in the occurrence of menstrual irregularities with increase in severity of hypothyroidism in our study (73.62% in SPH vs. 16.25% in ScH). The occurrence of menstrual irregularities in the Indian thyroid registry study and similar other studies have been 16%, similar to the rates observed in patients with ScH in our study.…”

“…The occurrence of menstrual irregularities in the Indian thyroid registry study and similar other studies have been 16%, similar to the rates observed in patients with ScH in our study. [1112] Evaluation of milder forms of hypothyroidism in previously reported studies explains the lower occurrence of menstrual irregularities in them. Studies among the Caucasian population have reported occurrence of menstrual irregularities of 20%-20% in patients with hypothyroidism.…”

Effect of radioactive iodine-induced hypothyroidism on longitudinal bone growth during puberty in immature female rats

“…As thyroid hormone increases basal metabolic rate [ 22 ], hypothyroidism might be associated with increased body weight. Indeed, a number of clinical studies reported increased body weight gain in adult and children with hypothyroidism [ 14 , 31 ]. In contrast, most animal studies found decreased body weight both in adult [ 3 ] and immature [ 9 , 33 ] rats, in agreement with our results ( Fig.…”

Prevalence of Subclinical Hypothyroidism in an Otherwise Healthy Population– A Study

“…The only way to diagnose this type of disorder is by biochemical testing because the clinical results shows a lot of variation. As per the literature, it has been reported that the prevalence of SCH is more common in females then males and also this disorder increases with the age [3]. There are a number of consequences of SCH which includes the increased risk of cardiovascular diseases, lead to sub fertility, low birth weight and also miscarriages.…”