2011
DOI: 10.1210/en.2011-1210
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The Thyroid Hormone-Inactivating Type III Deiodinase Is Expressed in Mouse and Human β-Cells and Its Targeted Inactivation Impairs Insulin Secretion

Abstract: Deiodinases are selenoproteins that activate or inactivate thyroid hormone. During vertebrate development, these pathways control thyroid hormone action in a cell-specific fashion explaining how systemic thyroid hormone can affect local control of tissue embryogenesis. Here we investigated the role of the thyroid hormone-inactivating deiodinase (D3) in pancreatic islet function and glucose homeostasis. D3 expression was determined by real-time PCR, immunofluorescence, and enzyme activity. Embryonic and adult w… Show more

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Cited by 69 publications
(70 citation statements)
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“…Knockout of the Dio3 gene causes perinatal thyrotoxicity and partial lethality at or before birth (Hernandez et al 2006). Birth weight is normal in the live mutant pups but there are abnormalities in the pancreatic b-cells, retina, and hypothalamus at birth with a more severe growthrestricted phenotype developing with increasing postnatal age (Hernandez et al 2006, Ng et al 2010, Medina et al 2011, Ueta et al 2012. The tissue-specific patterns of imprinting and expression of Dio3 suggest that this deiodinase has both paracrine and endocrine actions in preventing feto-placental over exposure to thyroid hormones at critical stages of development.…”
Section: Metabolism Of Thyroid Hormones In Uteromentioning
confidence: 99%
“…Knockout of the Dio3 gene causes perinatal thyrotoxicity and partial lethality at or before birth (Hernandez et al 2006). Birth weight is normal in the live mutant pups but there are abnormalities in the pancreatic b-cells, retina, and hypothalamus at birth with a more severe growthrestricted phenotype developing with increasing postnatal age (Hernandez et al 2006, Ng et al 2010, Medina et al 2011, Ueta et al 2012. The tissue-specific patterns of imprinting and expression of Dio3 suggest that this deiodinase has both paracrine and endocrine actions in preventing feto-placental over exposure to thyroid hormones at critical stages of development.…”
Section: Metabolism Of Thyroid Hormones In Uteromentioning
confidence: 99%
“…This is also observed in animal models of transgenic Dio2 expression in the heart (273,274). In contrast, D3 inactivation results in localized increase in thyroid hormone signaling as evidenced in the D3 KO mouse (64,239,(275)(276)(277)(278)(279).…”
Section: [F1] Thyrotoxicosis In Animalsmentioning
confidence: 99%
“…Maternal hypothyroidism caused impaired insulin secretion in neonatal rats as well as glucose intolerance and b-cell dysfunction in adult offspring (9). Systemic knockout of Dio3 (the enzyme required for intracellular inactivation of thyroid hormones) caused significantly reduced islet area and pancreatic insulin content compared with wild-type mice at birth as well as glucose intolerance and impaired insulin secretion during adulthood (10). Triiodothyronine (T3) has also been shown to have prosurvival effects on adult b-cells by protecting mice from streptozotocin-induced b-cell death and diabetes (11).…”
mentioning
confidence: 99%