The Thyroid Function and Size in Healthy Man During 3 Weeks Treatment with β-Adrenoceptor-Antagonists

Kayser, Lars; Perrild, Hans; Feldt‐Rasmussen, Ulla; Hegedüs, Laszlo; Skovsted, L.; Jm, Hansen

doi:10.1055/s-2007-1003605

Cited by 4 publications

(8 citation statements)

References 7 publications

(10 reference statements)

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“…Beta-blockers inhibit the conversion of T 4 to the more active form, T3, and increase serum TSH (Kayser et al 1991). Use of these drugs was positively associated with TSH in the regression for women with urinary iodine < 100 μg/L.…”

Section: Discussionmentioning

confidence: 99%

Urinary Perchlorate and Thyroid Hormone Levels in Adolescent and Adult Men and Women Living in the United States

Blount

Pirkle

Osterloh

et al. 2006

Environ Health Perspect

290

235

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BackgroundPerchlorate is commonly found in the environment and known to inhibit thyroid function at high doses. Assessing the potential effect of low-level exposure to perchlorate on thyroid function is an area of ongoing research.ObjectivesWe evaluated the potential relationship between urinary levels of perchlorate and serum levels of thyroid stimulating hormone (TSH) and total thyroxine (T4) in 2,299 men and women, ≥ 12 years of age, participating in the National Health and Nutrition Examination Survey (NHANES) during 2001–2002.MethodsWe used multiple regression models of T4 and TSH that included perchlorate and covariates known to be or likely to be associated with T4 or TSH levels: age, race/ethnicity, body mass index, estrogen use, menopausal status, pregnancy status, premenarche status, serum C-reactive protein, serum albumin, serum cotinine, hours of fasting, urinary thiocyanate, urinary nitrate, and selected medication groups.ResultsPerchlorate was not a significant predictor of T4 or TSH levels in men. For women overall, perchlorate was a significant predictor of both T4 and TSH. For women with urinary iodine < 100 μg/L, perchlorate was a significant negative predictor of T4 (p < 0.0001) and a positive predictor of TSH (p = 0.001). For women with urinary iodine ≥ 100 μg/L, perchlorate was a significant positive predictor of TSH (p = 0.025) but not T4 (p = 0.550).ConclusionsThese associations of perchlorate with T4 and TSH are coherent in direction and independent of other variables known to affect thyroid function, but are present at perchlorate exposure levels that were unanticipated based on previous studies.

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Section: Discussionmentioning

confidence: 99%

Urinary Perchlorate and Thyroid Hormone Levels in Adolescent and Adult Men and Women Living in the United States

Blount

Pirkle

Osterloh

et al. 2006

Environ Health Perspect

290

235

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“…But Kayser et al have demonstrated that after a 1-week therapy of propranolol and atenolol, median serum TSH levels increased, whereas median serum TSH decreased compared with pretreatment values after 3 weeks of therapy. However, the increase of TSH levels under the treatment of metoprolol did not reach statistical significance ( Kayser et al, 1991 ).…”

Section: Discussionmentioning

confidence: 99%

“…Antihypertensive drugs used widely in clinical practice include β-blockers, angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB), and calcium channel blockers (CCB) in our hospital. Evidence has linked propranolol therapy to a thyroid function alteration in patients with hyperthyroidism ( Faber et al, 1979 ; Perret et al, 1984 ; Franklyn et al, 1985 ) and euthyroidism ( Wilkins et al, 1985 ; Kayser et al, 1991 ). In recent years, selective β 1 -adrenergic receptor blockers (second-generation agents) and third-generation agents ( Rizos et al, 2003 ; Bakris et al, 2004 ; Celik et al, 2006 ) are much more prevalent in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, selective β 1 -adrenergic receptor blockers (second-generation agents) and third-generation agents ( Rizos et al, 2003 ; Bakris et al, 2004 ; Celik et al, 2006 ) are much more prevalent in clinical practice. However, the evidence for thyroid function-changing effect of second- and third-generation β 1 -adrenergic receptor blockers in euthyroid cases shows contrary outcomes ( Kristensen and Weeke, 1977 ; Faber et al, 1979 ; Perret et al, 1984 ; Reeves et al, 1985 ; Kayser et al, 1991 ). The effect of ACEI, ARB ( Hume et al, 1990 ; Vranckx et al, 1995 ; Andjelkovic et al, 2016 ) and CCB ( Brabant et al, 1989 ; Jangid, 1993 ; Eidne et al, 1994 ; Roussel et al, 1995 ; Roussel et al, 1997 ; Pedemonte et al, 2005 ) on thyroid function were not consistent between animal study and clinical studies and the sample size was small ( Isles et al, 1985 ; Haitas et al, 1986 ; Valensi et al, 1989 ; Andjelkovic et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Antihypertensive Drugs on Thyroid Function in Type 2 Diabetes Patients With Euthyroidism

et al. 2022

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Objective: There is little literature about whether antihypertensive drugs would affect thyroid function in patients with euthyroid type 2 diabetes, which was significant in maintaining a proper balance of thyroid function. A retrospective cohort study was conducted to evaluate the influence of antihypertensive drugs on thyroid function in patients with type 2 diabetes with euthyroidism.Design and Methods: The study involved dividing 698 patients with antihypertensive monotherapy into five groups according to the antihypertensive drugs they were treated with. Antihypertensive drugs included in this study were β-blockers, angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB), and calcium channel blockers (CCB). The clinical data and thyroid function level between or within groups were compared. Multiple logistic regression analysis was conducted to evaluate the association of antihypertensive drugs with thyroid function level.Results: Selective β1- adrenergic receptor blockers treatment was related to thyroid-stimulating hormone (TSH), increasing in patients with diabetes and euthyroidism as shown by multiple logistic regression analysis. The association existed after adjustment for confounding factors. No significant influence on thyroid function was found among other antihypertensive drugs.Conclusion: These data show the TSH-lifting effect of selective β1-adrenergic receptor blockers in patients with type 2 diabetes with euthyroidism.

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confidence: 99%

Effect of Posture on Total Thyroxine Plasma Concentration

Abalan¹,

Hui-Bon-Hoa²,

Dufrechou³

et al. 1991

Horm Metab Res

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Sir, Kayser, Perrild, Feldt-Rasmussen, Hegediis, Skovsted and Hansen (1991) have measured thyroxine (Tt) serum levels. Standing for 35 minutes increases venous hematocrit, haemoglobin and plasma protein levels by 10. 3%, 10.8% and 20.8% respectively (Hagan, Diaz and Horvath 1978). Standing for 90 minutes raises serum total calcium from 96.8 mg/1 to 100.2 mg/1 (Husdan, Rapoport and Locke 1973). Standing for 15 minutes increases plasma cholesterol concentrations by 10.4% and plasma triglyceride concentrations by 12.4% {Tan, Wilmshurst, Gleason and Soeldner 1973). Standing for 30 to 40 minutes increases vitamin B12 and folate plasma levels by more than 10% (Abalan, Toulet, Tignol, Lacoste, Brument, Vuillemin, Ducassou and Couzigou 1987). Standing for 45 minutes increases total phenytoin plasma concentration by 10.5% {Abalan, Vincon, Ellison, Sousselier, Demotes-Mainard, Lachiver and Albin 1990). The explanation is that when the subject stands, fluid (up to 23 % of plasma volume) (Fawcett and Wytin 1960) leaves the circulation under hydrostatic forces, particularly in the lower limbs (Hagan, Diaz and Horvath 1978;Waterfleld 1931) which swell (Waterfield 1931. This leads to an increase in concentrations of blood constituents such as red-cells, proteins and protein-bound substances (calcium, etc.), which do not readily pass through the capillary membrane. Reverting to the horizontal position reverses these changes. Changes are relatively stable 30 minutes after the modification of posture (Hagan, Diaz and Horvath 1978).T4 is highly bound to plasma proteins (more than 99.9 %) so it is highly likely that standing increases its total plasma concentration. To test this hypothesis, the following experiment was conducted.

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The Thyroid Function and Size in Healthy Man During 3 Weeks Treatment with β-Adrenoceptor-Antagonists

Cited by 4 publications

References 7 publications

Urinary Perchlorate and Thyroid Hormone Levels in Adolescent and Adult Men and Women Living in the United States

Urinary Perchlorate and Thyroid Hormone Levels in Adolescent and Adult Men and Women Living in the United States

Effects of Antihypertensive Drugs on Thyroid Function in Type 2 Diabetes Patients With Euthyroidism

Effect of Posture on Total Thyroxine Plasma Concentration

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