The Thymic "Myoidzellen" and Myasthenia Gravis

Velde, Robert L. Van de

doi:10.1001/jama.1966.03110160115033

Cited by 55 publications

(3 citation statements)

References 4 publications

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“…We have found these cells to be present in calf thymus, and to show the staining characteristics of muscle, to contain KMEF protein (probably myosin) and glycogen, and to have the histochemical characteristics of small striated-muscle fibres. Whether these cells provide the antigenic stimulus for the immunological abnormalities of myasthenia (Goldstein and Whittingham, 1966;Van de Velde and Friedman, 1966), or are simply remnants of branchial mesoderm, remains unanswered.…”

Section: Discussionmentioning

confidence: 99%

“…Initially these cells were thought to be epithelial reticular cells but more recent studies identify them with muscle-like cells. The most comprehensive studies of these cells is that of Van de Velde andFriedman (1966, 1967) who showed the cells to be present as elongate, striated myoid cells in the early foetal thymus of mammals, but subsequently losing their striations, becoming rounded, and disappearing before birth. In lower vertebrates they persist and can be found in the thymus of adult amphibians and reptiles.…”

Section: Histology and Histochemistry Of Thymusmentioning

confidence: 99%

See 1 more Smart Citation

Experimental studies related to autoimmunity in myasthenia gravis.

Kaufman¹,

Rushworth²,

Wright³

1969

Journal of Neurology, Neurosurgery & Psychiatry

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Section: Discussionmentioning

confidence: 99%

Section: Histology and Histochemistry Of Thymusmentioning

confidence: 99%

Experimental studies related to autoimmunity in myasthenia gravis.

Kaufman¹,

Rushworth²,

Wright³

1969

Journal of Neurology, Neurosurgery & Psychiatry

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“…The presence of myoid cells in the thymomas has been first demonstrated by Van de Velde and Friedman 2 . Another case was reported as unusual thymic tumour with striated muscle by Henry 3 .…”

mentioning

confidence: 86%

Pericardial rhabdomyomatous spindle cell thymoma with mucinous cystic degeneration

et al. 2001

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Congenital Myasthenia Gravis

Clarke¹,

Velde²

1971

Am J Dis Child

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Thymectomy and subsequent short course of corticotropin in high doses did not change the course of persistent and unusually severe congenital myasthenia gravis in a 5-year-old boy. Grossly, the thymus appeared normal in size and consistency for the patient's age. On histopathologic examination several changes consistent with an autoimmune disorder were demonstrable, including lymphoid hyperplasia and large numbers of thymic plasma cells. Electron microscopic studies showed intralobular vascular changes and the presence of thymic myoid cells. Their possible significance is discussed.Although myasthenia gravis in the neonate is not common, a sufficient number of cases have been reported to allow classification into neonatal and congenital forms (Table). Neonatal myasthenia is more common and appears in 10% to 15% of infants born of myasthénie mothers. This form of myasthenia is transitory and medication is rarely required for longer than four weeks. Survival

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The Thymic "Myoidzellen" and Myasthenia Gravis

Cited by 55 publications

References 4 publications

Experimental studies related to autoimmunity in myasthenia gravis.

Experimental studies related to autoimmunity in myasthenia gravis.

Pericardial rhabdomyomatous spindle cell thymoma with mucinous cystic degeneration

Congenital Myasthenia Gravis

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