The Three Paralogous MicroRNA Clusters in Development and Disease, miR-17-92, miR-106a-363, and miR-106b-25

Khuu, Cuong; Utheim, Tor Paaske

doi:10.1155/2016/1379643

Cited by 63 publications

(81 citation statements)

References 114 publications

(117 reference statements)

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“…For miR-106a/b that belongs to paralogous miRNA gene clusters (the miR-17-92, miR-106a-363, and miR-106b-25 microRNA precursor families) [21], the two mature miRNAs were associated with dementia, i.e., miR-106b-5p was upregulated in participants who developed dementia, while miR-106a-5p was downregulated (borderline associated, p -value = 0.1). Another interesting finding was that miR-146b-5p was downregulated in twins who were diagnosed with dementia (Table 2).…”

Section: Resultsmentioning

confidence: 99%

Circulating, Cell-Free Micro-RNA Profiles Reflect Discordant Development of Dementia in Monozygotic Twins

Mengel‐From

Svensson

Carlsen

et al. 2018

JAD

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We aim to examine if circulating micro-RNA and cytokine levels associate with dementia diagnosis and cognitive scores. To test our hypothesis, we use plasma donated from 48 monozygotic twin pairs in 1997 and 46 micro-RNAs and 10 cytokines were quantified using microfluidic RT-qPCR and multiplex solid-phase immunoassays, respectively. Micro-RNA and cytokine profiling were examined for associations with dementia diagnoses in a longitudinal registry study or with cognitive scores at baseline. Thirty-six micro-RNAs and all cytokines were detected consistently. Micro-RNA profiles associate with diagnoses and cognitive scores at statistically significant levels while cytokine only showed trends pointing at chronic inflammation in twins having or developing dementia. The most notable findings were decreased miR-106a and miR-210, and increased miR-106b expression in twins with a dementia diagnosis. This pioneering evaluation of micro-RNA and cytokine and dementia diagnosis suggests micro-RNA targets in vasculogenesis, lipoprotein transport, and amyloid precursor protein genes.

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Section: Resultsmentioning

confidence: 99%

Circulating, Cell-Free Micro-RNA Profiles Reflect Discordant Development of Dementia in Monozygotic Twins

Mengel‐From

Svensson

Carlsen

et al. 2018

JAD

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“…MiR‐19 is a member of miR‐17‐92 cluster, this cluster participates not only in the development of heart and lung,7, 8 but also in ageing and cancer 9. The target genes of miR‐17‐92 cluster have been experimentally identified so far including: STAT3, Mapk1410 and Rb2/p130 11.…”

Section: Introductionmentioning

confidence: 99%

The emerging role of miR‐19 in glioma

Wang

Zhang

Hao

et al. 2018

J Cellular Molecular Medi

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Glioma has been regarded as the most common, highly proliferative and invasive brain tumour. Advances in research of miRNAs in glioma are toward further understanding of the pathogenesis of glioma. MiR‐19, a member of miR‐17~92 cluster, was reported to play an oncogenic role in tumourigenesis. Here we review the identified data about the effect of miR‐19 on proliferation, apoptosis, migration and invasion of glioma cells, the target genes regulated by miR‐19, and correlation of miR‐19 with the sensitivity of glioma cells to chemotherapy and radiotherapy. It is concluded that miR‐19 plays an important role in the pathogenesis of glioma and can be a potential target for gene therapy of glioma.

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“…The miR-106b-25 cluster is located in the thirteenth intron of the DNA replication gene minichromosome maintenance complex component 7 (MCM7), which resides on chromosome 7 in humans and encodes three miRNAs: miR-106b, miR-93 and miR-25. A previous study revealed that members of the miR-106b-25 cluster are overexpressed in several types of cancer (14).…”

Section: Introductionmentioning

confidence: 99%

Function of miR‑25 in the invasion and metastasis of esophageal squamous carcinoma cells and bioinformatical analysis of the miR-106b-25 cluster

Wang

Yang

Jin³

et al. 2017

Exp Ther Med

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Abstract. MicroRNAs (miRNAs/miRs) are a class of small, non-coding RNA molecules that serve a key function in carcinogenesis and tumor progression. Recent evidence indicates that miRNAs may act as powerful regulators of migration and invasion. The present study aimed to investigate the effect of miR-25 on the invasion and metastasis of KYSE-150 and EC109 esophageal squamous cell carcinoma (ESCC) cells, and predict the mechanism of this effect by bioinformatically analyzing the miR-106b-25 cluster. In order to alter the expression of miR-25 in the two cell lines, a miR-25 inhibitor or mimic were transfected into the cells, which were then studied via Transwell migration and invasion assays. Subsequently, the target genes of the miR-106b-25 cluster were predicted using miRanda, PicTar, TargetScan and miRTarbase, and the functions of the target genes were predicted via Gene Ontology term and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses. Then, a protein-protein interaction (PPI) network was produced using the Search Tool for the Retrieval of Interacting Genes. The results revealed that overexpressing miR-25 led to significantly increased cell migration and invasion in KYSE150 and EC109 cells. Suppressing miR-25 resulted in significantly decreased cell migration and invasion in KYSE150 cells, while the result was not significant in EC109 cells. Target genes of the miR-106b-25 cluster were significantly enriched in the biological process regulation of cellular metabolic process and several cancer-associated pathways, such as those for glioma and melanoma. The PPI network revealed that PTEN, TP53, MDM2, E2F1, PRMT5, MCM2, RB1, CDKN1A, SHAD7 and EZH2 may serve core roles within the network and associate with one another during the pathogenesis of ESCC. These results indicate that a high expression of miR-25 promotes the invasion and metastasis of ESCC cells, while the influence of low expression of miR-25 differs with cells with different degrees of differentiation. Invasion and metastasis are not effected in cells with poor differentiation, while they were decreased in well differentiated cells. Furthermore, PTEN, TP53, MDM2, E2F1, PRMT5, MCM2, RB1, CDKN1A, SHAD7 and EZH2 may be targeted by the miR-106b-25 cluster, and act together to regulate the development of ESCC. IntroductionEsophageal cancer is an important public health problem worldwide, as the eighth most common cancer and sixth most common cause of cancer-associated mortality (1). Esophageal squamous cell carcinoma (ESCC) accounts for 90% of all histological types of esophageal carcinoma in the highest risk area, North-central China, which ranks first in ESCC morbidity and mortality rates (2). Genetic heterogeneity and complex regulatory networks make it difficult to treat ESCC (3). Thus, identifying the regulatory pathways for the stratification of ESCC is of great clinical significance.MicroRNAs (miRNAs/miRs) are single-stranded RNAs of 18-24 nucleotides in length that post-transcriptionally regulate gene expression by directly bindin...

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The Three Paralogous MicroRNA Clusters in Development and Disease, miR-17-92, miR-106a-363, and miR-106b-25

Cited by 63 publications

References 114 publications

Circulating, Cell-Free Micro-RNA Profiles Reflect Discordant Development of Dementia in Monozygotic Twins

Circulating, Cell-Free Micro-RNA Profiles Reflect Discordant Development of Dementia in Monozygotic Twins

The emerging role of miR‐19 in glioma

Function of miR‑25 in the invasion and metastasis of esophageal squamous carcinoma cells and bioinformatical analysis of the miR-106b-25 cluster

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