The “three‐in‐one” formulation of bismuth quadruple therapy for <i>Helicobacter pylori</i> eradication with or without probiotics supplementation: Efficacy and safety in daily clinical practice

Zagari, Rocco Maurizio; Romiti, A.; Ierardi, Enzo; Gravina, Antonietta Gerarda; Panarese, Alba; Grande, Giuseppe; Savarino, Edoardo; Maconi, Giovanni; Stasi, Elisa; Eusebi, Leonardo Henry; Farinati, Fabio; Conigliaro, Rita; Bazzoli, Franco; Romano, Marco

doi:10.1111/hel.12502

Cited by 43 publications

(54 citation statements)

References 21 publications

(70 reference statements)

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“…In recent large multicenter studies, elaborate re‐education is generally instructed throughout the trial to achieve high H pylori eradication rate, with patients’ adherence around 94%, sometimes even 100% . However, most studies performed in China revealed that the compliance during H pylori eradication is unpleasant in clinical practice .…”

Section: Discussionmentioning

confidence: 99%

“…Previous study in our hospital showed the clarithromycin resistance rate in Shandong province had reached around 30%. As resistance to clarithromycin in China rapidly develops in last decades, some researchers proposed that the choice of clarithromycin‐containing regimen should rely on local resistance patterns and personal medical history …”

Section: Discussionmentioning

confidence: 99%

“…In recent large multicenter studies, elaborate re-education is generally instructed throughout the trial to achieve high H pylori eradication rate, with patients' adherence around 94%, sometimes even 100%. [19][20][21] However, most studies performed in China revealed that the compliance during H pylori eradication is unpleasant in clinical practice. [22][23][24] A prospective study conducted by Abbasinazari et al 25 reported that while regimen type was not relative to patients' adherence, the frequency of dosing and numbers of medications affected the adherence to treatment.…”

Section: Discussionmentioning

confidence: 99%

“…As resistance to clarithromycin in China rapidly develops in last decades, some researchers proposed that the choice of clarithromycin-containing regimen should rely on local resistance patterns and personal medical history. 20 Our study explored a novel approach of re-education in view…”

Section: Discussionmentioning

confidence: 99%

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Twice daily short‐message‐based re‐education could improve Helicobacter pylori eradication rate in young population: A prospective randomized controlled study

Wang

Yang

et al. 2019

Helicobacter

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Background To investigate the effects of twice daily short‐message‐based re‐education (SMRE) before taking medicine for Helicobacter pylori (H pylori) eradication. Materials and Methods Treatment‐naive patients with H pylori infection were prescribed 14‐day quadruple regimen consisting of lansoprazole 30 mg, colloidal bismuth pectin 200 mg, amoxicillin 1000 mg, and clarithromycin 500 mg twice daily. Patients were randomly allocated to SMRE group or control group. Patients in control group received oral and written instructions at outpatient clinic. In contrast, patients in the SMRE group received extra short messages including dosage and time of administration twice daily. Successful H pylori eradication was assessed using the 13C‐urea breath test 6 weeks after treatment. The compliance, adverse events, and patient satisfaction were also analyzed. Results A total of 310 patients were enrolled in the intention‐to‐treat (ITT) and 283 in the per‐protocol (PP) analysis. For young patients, the eradication rates were significantly higher in SMRE group than those in control group in PP analysis (88.6% vs 71.2%, P = 0.036), while for patients of all age groups, the eradication rate improvements were not statistically significant. The eradication rates in SMRE group and control group were 74.2% and 67.7% (P = 0.211) in ITT analysis and 82.1% and 73.4% (P = 0.078) in PP analysis, respectively. The compliance in SMRE group was significantly better than that in control group (84.8% vs 72.8%, P = 0.011). Conclusions Twice daily SMRE could improve the eradication rate in young population, as well as the compliance with treatment during H pylori eradication.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Twice daily short‐message‐based re‐education could improve Helicobacter pylori eradication rate in young population: A prospective randomized controlled study

Wang

Yang

et al. 2019

Helicobacter

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“…These are summarized inTable 2 52,53. No significant difference between the eradication rates was achieved by both regimens (86% vs 87%).…”

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confidence: 91%

Review: Treatment of Helicobacter pylori Infection 2019

et al. 2019

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This review summarizes important studies regarding Helicobacter pylori therapy published from May 2018 to May 2019. The main themes that emerge involve studies assessing the efficacy of bismuth‐based regimens. While in recent years the efficacy of bismuth‐based quadruple therapy as a second‐line therapy has been clearly established, there is now substantial evidence that it is the best performing first‐line therapy. Antibiotic resistance was again intensely studied this year, and a clear and dramatic increase in resistance is noted for clarithromycin and levofloxacin; most notably, it may not be possible to support these therapies in most regions of the world much longer without testing. The utility of vonoprazan as an alternative to proton‐pump inhibitor therapy, especially in resistant and difficult to treat groups, has also been considered in greater detail this year, as well as means of supporting and enhancing adherence to therapy. Several studies showed that the diversity of gut microbiota was significantly altered shortly after H pylori eradication. However, the diversity was restored to pre‐treatment state after 2 months in patients treated with triple therapy. More studies are warranted to assess the long‐term changes of gut microbiota after H pylori eradication.

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Role of Bacterial Infection (H. pylori) in Colon Carcinogenesis and Therapeutic Approaches

Singh

Tiwari

Mehdi

et al. 2021

Colon Cancer Diagnosis and Therapy

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The “three‐in‐one” formulation of bismuth quadruple therapy for Helicobacter pylori eradication with or without probiotics supplementation: Efficacy and safety in daily clinical practice

Abstract: The three-in-one BQT is highly effective and well tolerated for H. pylori eradication in daily clinical practice. Probiotics supplementation fails to improve compliance.

Cited by 43 publications

References 21 publications

Twice daily short‐message‐based re‐education could improve Helicobacter pylori eradication rate in young population: A prospective randomized controlled study

Twice daily short‐message‐based re‐education could improve Helicobacter pylori eradication rate in young population: A prospective randomized controlled study

Review: Treatment of Helicobacter pylori Infection 2019

Role of Bacterial Infection (H. pylori) in Colon Carcinogenesis and Therapeutic Approaches

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