The three-dimensional ultrasonographic ovarian vascularity of women developing poor ovarian response during assisted reproduction treatment and its predictive value

Jayaprakasan, Kannamannadiar; Al-Hasie, H. A.; Jayaprakasan, Rajisha; Campbell, Bruce; Hopkisson, James; Johnson, I. R.; Raine‐Fenning, Nick

doi:10.1016/j.fertnstert.2008.09.031

Cited by 31 publications

(14 citation statements)

References 38 publications

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“…The fact that depressing AMH bioavailability resulted in an increase in the population of gonadotropin-dependent follicles and an increase in ovulation rate indicates that this intervention may be of potential value to enhance response to ovarian stimulation (39,40). In terms of anovulatory infertility, it is well established that the primary physiological characteristic of PCOS is a failure of the mechanism which results in the selection of one member of the gonadotropin-dependent follicular cohort to undergo final differentiation to become an estrogenic preovulatory-sized follicles (41).…”

Section: Discussionmentioning

confidence: 99%

The Role of Anti-Müllerian Hormone (AMH) During Follicle Development in a Monovulatory Species (Sheep)

2012

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Knockout studies in mice have suggested that anti-Müllerian hormone (AMH) modulates primordial follicle recruitment and the response of growing follicles to FSH. Little is known of the physiology of AMH in monovular species, despite intense clinical interest in this factor. Using sheep as a model, we sought to investigate the functional role of AMH in modulating follicle development in monovular species. In contrast to the rodent, the results indicate that AMH does not affect the rate of primordial follicle recruitment but appears to regulate the rate at which follicles progress through the gonadotropin-responsive phase, during which it is maximally expressed. Thus, knockdown of AMH bioactivity by active immunization lead to a decline in the population of gonadotropin-responsive preantral and small antral follicles (P < 0.01) and increases in both the number of gonadotropin-dependent antral follicles (P < 0.01) and ovulation rate (P < 0.05). These in vivo findings were consistent with the results of other studies examining the pattern of expression of AMH, which was negatively correlated with aromatase (P < 0.001), and in vitro supplementation experiments, which supported an inhibitory role for AMH in modulating the response of both theca and granulosa cells to LH and FSH, respectively. The elucidation of a functional relationship between AMH and LH-stimulated thecal androgen production may be significant in terms of the etiology of common forms of anovulatory infertility in women. Furthermore, the observed increase in both the number of recruitable antral follicles and ovulatory quota in response to AMH knockdown may have therapeutic value in women who respond poorly to ovarian stimulation.

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Section: Discussionmentioning

confidence: 99%

The Role of Anti-Müllerian Hormone (AMH) During Follicle Development in a Monovulatory Species (Sheep)

2012

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“…In recent years, attention has shifted to direct tests such as ovarian volume and antral follicle count (AFC). Previous studies have shown that ovarian volume and the number of antral follicles are meaningful variables for determining ovarian reserve (4)(5)(6)(7)(8)(9).…”

mentioning

confidence: 99%

The effect of laparoscopic ovarian cystectomy versus coagulation in bilateral endometriomas on ovarian reserve as determined by antral follicle count and ovarian volume: a prospective randomized study

Var

Batıoğlu

Tonguç

et al. 2011

Fertility and Sterility

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“…The ovarian stromal VI, FI and VFI were significantly increased in hyperresponders [34], and decreased in women with poor response to ovarian stimulation when compared with women with normal response [35]. However, Jayaprakasan et al have demonstrated that the antral follicle count is the single best predictor of poor ovarian response [36]. Ovarian vascularity indices measured by 3D ultrasound are not decreased in women with poor response during IVF treatment.…”

Section: Ovulation Induction and Infertilitymentioning

confidence: 95%

Three-dimensional Ultrasound in Evaluation of the Ovary

Cheng

Chang

et al. 2012

Journal of Medical Ultrasound

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KEY WORDSovary, three-dimensional ultrasonography Three-dimensional (3D) ultrasound is an easy, important and noninvasive method for the differential diagnosis of ovarian disease in the clinical practice of obstetrics and gynecology. With advances in ultrasonographic technology, the application of higher-frequency scanning probes can evaluate the ovary in the analysis of morphological anatomy and in volume measurement, and is highly reproducible. The potential of power Doppler ultrasound with vascular indices that can further depict and quantify the microcirculation of the ovary has been extensively explored. The aim of this review is to report the present status and the recent development of 3D ultrasonography in the evaluation of the ovary. In conclusion, 3D ultrasound examination may help us to investigate the functional and potential roles of ultrasonography in clinical practice concerned with the ovary. Furthermore, 3D ultrasound may provide more substantial assistance in the differential diagnosis of various physiological or pathological conditions of the ovary. ª

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The three-dimensional ultrasonographic ovarian vascularity of women developing poor ovarian response during assisted reproduction treatment and its predictive value

Cited by 31 publications

References 38 publications

The Role of Anti-Müllerian Hormone (AMH) During Follicle Development in a Monovulatory Species (Sheep)

The Role of Anti-Müllerian Hormone (AMH) During Follicle Development in a Monovulatory Species (Sheep)

The effect of laparoscopic ovarian cystectomy versus coagulation in bilateral endometriomas on ovarian reserve as determined by antral follicle count and ovarian volume: a prospective randomized study

Three-dimensional Ultrasound in Evaluation of the Ovary

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