“…Trabecular bone VOI data (whole body and spherical VOI) were processed with an adaptive, iterative threshold (detailed in Ridler and Calvard, 1978;Trussell, 1979;Ryan and Ketcham, 2002;Meinel et al, 2005;Maga et al, 2006). In the vbVOI, the following three-dimensional trabecular bone structural and fabric properties (Table 2) were measured without any model assumptions (Parfitt et al, 1983;Guldberg et al, 2003) or concern for caveats related to measurements in two dimensional sections (i.e., stereology, Underwood, 1970;Weibel, 1979Weibel, , 1980: trabecular bone volume (Tb.BV), trabecular bone volume fraction (Tb.BV/TV), structure model index (Tb.SMI) (Hildebrand and Ruegsegger, 1997a), trabecular number (Tb.N) (Hildebrand et al, 1999), trabecular thickness (Tb.Th) (Hildebrand and Rü egsegger, 1997b), trabecular separation (Tb.Sp) (Hildebrand et al, 1999), connectivity density (Tb.Conn.D), and the degree of anisotropy (Laib et al, 2000;Fajardo et al, 2007a).…”