The three‐dimensional structure of the Vint domain from Tetrahymena thermophila suggests a ligand‐regulated cleavage mechanism by the HINT fold
Hideo Iwaï,
Hannes M. Beyer,
Julia E. M. Johansson
et al.
Abstract:Vint proteins have been identified in unicellular metazoans as a novel hedgehog‐related gene family, merging the von Willebrand factor type A domain and the Hedgehog/INTein (HINT) domains. We present the first three‐dimensional structure of the Vint domain from Tetrahymena thermophila corresponding to the auto‐processing domain of hedgehog proteins, shedding light on the unique features, including an adduct recognition region (ARR). Our results suggest a potential binding between the ARR and sulfated glycosami… Show more
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