This chapter explores a comprehensive approach to mitigating plastic pollution in freshwater ecosystems, aligning recommendations with the United Nations Sustainable Development Goals (SDGs). Regulatory measures, including extended producer responsibility and waste management infrastructure, are essential to curb plastic production. Mitigation strategies emphasize technological innovations, nature-based solutions, and individual actions. Education and outreach activities, targeting schools, communities, and businesses, play a pivotal role in preventing future pollution. Challenges and research needs highlight the evolving nature of the issue, necessitating a deeper understanding of plastic sources, long-term effects, and effective monitoring techniques. The interdisciplinary approach presented integrates environmental, social, and economic dimensions, emphasizing the interconnectedness of sustainability efforts.