The Third Annual Report on Stress

Selye, Hans; Horava, Alexander

doi:10.1097/00000441-195408000-00063

Cited by 17 publications

(4 citation statements)

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“…6 Seyle published his seminal article on stress in 1955 and book in 1956 and had already published his Fourth Annual Report on Stress by 1954. [72][73][74][75][76] Autonomic imbalance often led to sympathetic dominance, similar to stress theory. 8 Chiropractors were early to point out, however, that Selye emphasized the hormonal system and neglected the nervous system.…”

Section: B J Palmer's Theories and Final Contributionsmentioning

confidence: 95%

The Chiropractic Vertebral Subluxation Part 6: Renaissance of D.D. Palmer’s Paradigm From 1949 to 1961

Senzon

2018

Journal of Chiropractic Humanities

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Objective: The objective of this article is to review and discuss the history of chiropractic vertebral subluxation (CVS) between the years 1949 and 1961. Discussion: Chiropractic texts from this period include books from 3 of D. D. Palmer's students, Ratledge, Drain, and B. J. Palmer, and new works by Janse, Illi, Muller, and R. J. Watkins. Theories during this period included developments from B. J. Palmer's research clinic and his final theories. The period also included the primary theories of Ratledge on etiology of CVS and Drain's models of spinal curves and CVS patterns. Janse supported Illi's new models of pelvic subluxation dynamics with cadaver studies and also developed lumbar research with Fox in the 1950s. The qualitative models of Muller on the role of CVS in sympathetic and parasympathetic systems was unique. R. J. Watkins further developed his initial theories on reflex system models as well as his first models of proprioception. Instrumentation was used in many chiropractic research programs to develop additional models. Conclusion: The CVS theories during this period built on previous models but also added new and innovative theories based on research and collaboration.

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Section: B J Palmer's Theories and Final Contributionsmentioning

confidence: 95%

The Chiropractic Vertebral Subluxation Part 6: Renaissance of D.D. Palmer’s Paradigm From 1949 to 1961

Senzon

2018

Journal of Chiropractic Humanities

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“…The effects of stress and of the hormones produced during stress have been extensively discussed in several earlier monographs (2)(3)(4)(5)(6)(7)22). Here we shall place major emphasis upon those adaptive hormones that act either by accelerating the metabolic degradation of pathogens or through unknown mechanisms, as long as they increase resistance nonspecifically to many agents and do not merely rectify one particular homeostatic derangement.…”

Section: Historymentioning

confidence: 99%

“…The same is true of the bibliographies on the restoration of resistance by corticoids in adrenal insufficiency and on the hormonal control of various "pluricausal lesions." For details on all of these subjects, the reader is referred to the corresponding sections of several monographs (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Hormones and Resistance

Selye

1971

Journal of Pharmaceutical Sciences

105

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“…This observation likewise suggests that STH does exert some special kind of corti¬ cotrophic effect, which differs from that of ACTH [Selye, 1950;Selye & Bois, 1957]. It is significant that the ability of purified STH preparations to enlarge the adrenals in the presence of the hypophysis (like that of the impure beef anterior lobe extracts mentioned in the introductory paragraph) is considerably diminished after thyroidec¬ tomy [Selye, 1953].…”

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confidence: 99%

Enhancement by Thyroxine of the Adrenal-Stimulating Effect of Somatotrophic Hormone

Bois¹,

Selye²

1957

Journal of Endocrinology

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Experiments on intact Sprague-Dawley rats indicate that the adrenal enlargement produced by somatotrophic hormone (STH) can be greatly augmented by simultaneous treatment with comparatively small doses of thyroxine. Within a certain dosage range, the corticotrophic effect of STH is even proportionate to the dose of thyroxine given. The adrenal enlargement produced by adrenocorticotrophic hormone (ACTH), on the other hand, is not enhanced by concurrent treatment with thyroxine.Attention is called to the fact that, in rats in which adrenocortical hypertrophy is produced, either by STH plus thyroxine or by ACTH plus thyroxine, many of the changes in the extraadrenal organs, which are generally considered to be indicative of increased glucocorticoid production (inhibition of body weight gain, splenic atrophy, involution of the thymus and lymph nodes, inhibition of inflammatory exudate formation), do not parallel the increase in adrenal weight.It is now well established that the ability of the pituitary to exert its corticotrophic action is largely dependent upon the thyroid. We were able to show, for instance, that the adrenal-enlarging effect of crude anterior pituitary extracts can be markedly enhanced by simultaneous treatment with thyroxine [Selye, Béland & Stone, 1945; Selye, Stone, Nielsen & Leblond, 1945]. On the other hand, thyroidectomy diminished the corticotrophic effect of similarly prepared hypophysial extracts [Hay, 1946 a, 6]. It would have been tempting to ascribe these phenomena to some synergism be¬ tween the thyroid and the ACTH contained in the pituitary extracts, but, at that time, we used a very crude bovine anterior lobe preparation which was apparently poor in corticotrophin, judging by the slight degree of adrenal enlargement it induced when given without thyroxine. On the other hand, our extract was especially rich in somatotrophic hormone (STH), as judged by its effect upon somatic growth, and its ability to produce nephrosclerosis and myocarditis in rats (after suitable 'conditioning' by unilateral nephrectomy and NaCl supplements). This raised the question as to whether thyroxine could enhance the corticotrophic effect of some pituitary principle other than ACTH, perhaps that of STH. From our observations and from a survey of the literature, it seems doubtful whether STH preparations, which contain no demonstrable ACTH contamination, can stimulate the growth of the adrenal cortex in hypophysectomized animals, although they do exert a corticotrophic effect in intact rats. However, when such purified preparations are administered in combination with threshold doses of ACTH,

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The Third Annual Report on Stress

Cited by 17 publications

References 0 publications

The Chiropractic Vertebral Subluxation Part 6: Renaissance of D.D. Palmer’s Paradigm From 1949 to 1961

The Chiropractic Vertebral Subluxation Part 6: Renaissance of D.D. Palmer’s Paradigm From 1949 to 1961

Hormones and Resistance

Enhancement by Thyroxine of the Adrenal-Stimulating Effect of Somatotrophic Hormone

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