The Thermophysiology of Paradoxical Sleep

Pastukhov, Yu. F.; Екимова, И. В.

doi:10.1007/s11055-012-9660-5

Cited by 3 publications

(3 citation statements)

References 60 publications

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“…In pigeons, temperature in the visual hyperpallium decreased during NREM sleep and increased during REM sleep. Although this pattern is consistent with one study of hypothalamic temperature in pigeons, the average maximum increase was 10 times less in the hyperpallium (see Figure 1A in, Pastukhov and Ekimova, 2012). The smaller change in temperature in the hyperpallium, the most dorsal part of the avian brain, is consistent with the observation that although temperature covaries throughout the brain in awake and sleeping chickens, it varies less near the dorsal surface (Aschoff et al, 1973).…”

Section: Discussionsupporting

confidence: 90%

“…Notably, in most mammals examined, cortical and sub-cortical brain temperature (T br ) decreases during NREM sleep and increases during REM sleep (Kawamura and Sawyer, 1965;Hayward and Baker, 1969;Kovalzon, 1973;Obal et al, 1985;Wehr, 1992;Franken et al, 1992;Gao et al, 1995;Landolt et al, 1995;Csernai et al, 2019;Hoekstra et al, 2019;Komagata et al, 2019; see Baker, 1968 andBaker, 1969 for conflicting results in rhesus monkeys [Macaca mulatta]). Brain warming during REM sleep is thought to result from an increase in blood flow from the warmer body core to the brain to support this activity (Denoyer et al, 1991;Wehr, 1992;Parmeggiani, 2007;Pastukhov and Ekimova, 2012;Bergel et al, 2018). In this regard, brain warming might simply be a functionless by-product of functions that require increased neuronal activity, such as brain development and other types of synaptic plasticity.…”

Section: Introductionmentioning

confidence: 99%

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Comparative Perspectives that Challenge Brain Warming as the Primary Function of REM Sleep

et al. 2020

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Rapid eye movement (REM) sleep is a paradoxical state of wake-like brain activity occurring after non-REM (NREM) sleep in mammals and birds. In mammals, brain cooling during NREM sleep is followed by warming during REM sleep, potentially preparing the brain to perform adaptively upon awakening. If brain warming is the primary function of REM sleep, then it should occur in other animals with similar states. We measured cortical temperature in pigeons and bearded dragons, lizards that exhibit NREM-like sleep and REM-like sleep with brain activity resembling wakefulness. In pigeons, cortical temperature decreased during NREM sleep and increased during REM sleep. However, brain temperature did not increase when dragons switched from NREM-like to REM-like sleep. Our findings indicate that brain warming is not a universal outcome of sleep states characterized by wake-like activity, challenging the hypothesis that their primary function is to warm the brain in preparation for wakefulness.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Comparative Perspectives that Challenge Brain Warming as the Primary Function of REM Sleep

et al. 2020

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“…Notably, in most mammals examined, cortical and sub-cortical brain temperature (Tbr) decreases during NREM sleep and increases during REM sleep (Kawamura and Sawyer, 1965;Hayward and Baker, 1969;Kovalzon, 1973;Obal et al, 1985;Wehr, 1992;Franken et al, 1992;Gao et al, 1995;Landolt et al, 1995;Csernai et al, 2019;Hoekstra et al, 2019;Komagata et al, 2019; see Baker, 1968 andBaker, 1969 for conflicting results in rhesus monkeys (Macaca mulatta)). Brain warming during REM sleep is thought to result from an increase in blood flow from the warmer body core to the brain to support this activity (Denoyer et al, 1991;Wehr, 1992;Parmeggiani, 2007;Pastukhov and Ekimova, 2012;Bergel et al, 2018). In this regard, brain warming might simply be a functionless biproduct of functions that require increased neuronal activity, such as brain development and other types of synaptic plasticity.…”

Section: Introductionmentioning

confidence: 99%

Survivin silencing improved the cytotoxicity of carboplatin and melphalan in Y79 and primary retinoblastoma cells

Gibson

Derbali

Phan

et al. 2020

International Journal of Pharmaceutics

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Chaperone Hsp70 (HSPA1) Is Involved in the Molecular Mechanisms of Sleep Cycle Integration

Simonova

Guzeev

Екимова

et al. 2022

IJMS

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The molecular mechanisms of sleep cycle integration at the beginning and the end of the inactive period are not clear. Sleep cycles with a predominance of deep slow-wave sleep (SWS) seem to be associated with accelerated protein synthesis in the brain. The inducible Hsp70 chaperone corrects protein conformational changes and has protective properties. This research explores (1) whether the Hspa1 gene encoding Hsp70 protein activates during the daily rapid-eye-movement sleep (REMS) maximum, and (2) whether a lower daily deep SWS maximum affects the Hspa1 expression level during the subsequent REMS. Combining polysomnography in male Wistar rats, RT-qPCR, and Western blotting, we reveal a three-fold Hspa1 upregulation in the nucleus reticularis pontis oralis, which regulates REMS. Hspa1 expression increases during the daily REMS maximum, 5–7 h after the natural peak of deep SWS. Using short-term selective REMS deprivation, we demonstrate that REMS rebound after deprivation exceeds the natural daily maximum, but it is not accompanied by Hspa1 upregulation. The results suggest that a high proportion of deep SWS, usually observed after sleep onset, is a necessary condition for Hspa1 upregulation during subsequent REMS. The data obtained can inform the understanding of the molecular mechanisms integrating SWS and REMS and key biological function(s) of sleep.

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The Thermophysiology of Paradoxical Sleep

Cited by 3 publications

References 60 publications

Comparative Perspectives that Challenge Brain Warming as the Primary Function of REM Sleep

Comparative Perspectives that Challenge Brain Warming as the Primary Function of REM Sleep

Survivin silencing improved the cytotoxicity of carboplatin and melphalan in Y79 and primary retinoblastoma cells

Chaperone Hsp70 (HSPA1) Is Involved in the Molecular Mechanisms of Sleep Cycle Integration

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