The Therapeutic Use of Antioxidants for Melasma

Babbush, Kayla M.; Babbush, Remy A; Khachemoune, Amor

doi:10.36849/jdd.2020.5079

Cited by 40 publications

(32 citation statements)

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“…Moreover, age-related skin inflammation results in a compromised epidermal barrier, impaired moisture retention, erythema, scale, and pigment alteration [62]. The role of oxidative stress in melasma is well-defined, and it is documented that antioxidants possess clinical efficacy for the reduction in melanogenesis [63][64][65]. This is in line with our data, which suggest that TXF may be a new natural source of cosmetics, with therapeutic potential for patients with melasma.…”

Section: Discussionsupporting

confidence: 86%

Taxifolin as a Promising Ingredient of Cosmetics for Adult Skin

et al. 2021

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Active substances, effective in the reduction in or delay of skin changes caused by aging occurring in natural compounds, are desirable. Taxifolin (TXF), a flavonoid of strong antioxidant activity found in the plant Stizolophus balsamita (S. balsamita), has been tested for its biological effects on adult human skin. The aim of the study was to investigate the effects of two creams: 3% S. balsamita extract and 3% TXF on the function of adult skin. In total, 97 Caucasian women with clinical signs of skin aging were investigated. The biophysical and biomechanical skin parameters were measured before and after applying the creams, using Colorimeter CL400, Mexameter MX16, Skin-pH-Meter PH900, Skin-Thermometer ST 500, Glossymeter GL200, and Cutiscan SC100. Patch tests were performed with the investigated products to assess their potential irritant properties. The percutaneous penetration of creams was examined with the use of electrospray ionization mass spectrometry (ESI-MS) and confocal Raman spectroscopy. The 3% S. balsamita extract cream reduced hyperpigmentation, erythema, and elevated pH. All the tested preparations were proven to be nonirritant. A higher penetration rate was revealed for the 3% TXF cream than for the 3% S. balsamita extract cream. A total of 3% TXF cream improved skin viscoelasticity. The obtained results suggested that S. balsamita extract and TXF may be considered as ingredients of skincare products for adults.

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Section: Discussionsupporting

confidence: 86%

Taxifolin as a Promising Ingredient of Cosmetics for Adult Skin

et al. 2021

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“…4 Antioxidant properties of acupuncture in melasma also correlates with promising evidence for the use of antioxidants to deal with melasma in modern medicine. 14,28 Apart from the local effects, acupoints in the rest of the body acupoint-Fengchi (GB20), Hegu (LI4), Xuehai (SP10), Jusanli (ST36), Sanyinjiao (SP6) and Taichong (LR3)-have already been established to improve commonly seen syndromes of melasma patients: liver-qi stagnation, spleen-deficiency and kidney-yin/yang-deficiency. 18,29 In our study, the minor yet frequent adverse events of acupuncture were pain and hematoma in the facial area.…”

Section: Patient-reported Melasma-improvementmentioning

confidence: 99%

Short Practical Regimen of Acupuncture for Melasma: A Prospective Cohort Study in a Tertiary Hospital in Thailand

Supasiri¹,

Pongpirul

2021

Preprint

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Background: Melasma is a common skin pigmentation disorder. Acupuncture shows benefits for patients with melasma, although no standardized method or optimal number of sessions have been determined. Objective: To comparatively assess clinical outcomes of melasma between five vs ten standard acupuncture sessions. Methods: We performed a prospective observational cohort study in all melasma patients at the Acupuncture Clinic, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. All patients were treated with standard acupuncture procedure twice a week and were evaluated after the fifth and the tenth sessions of acupuncture, with a follow-up one week after the last session. Participants were divided into two treatment groups: Groups A and B received five and ten acupuncture sessions respectively. Melasma outcomes were assessed by using the Melanin Index (MI), Melasma Area and Severity Index (MASI), patient-reported improvement scores and acupuncture-related adverse events. Results: Of 113 participants, 67 received five sessions of acupuncture treatment while 39 received ten sessions. 7 participants did not finish treatment. After five sessions of acupuncture in Group A, the mean MI decreased by 28.7 (95%CI -38.5 to -18.8), whereas the median MASI decreased by 3.4 (-6.9, -1.2) points. After ten sessions of acupuncture in Group B, the mean MI decreased by 31.3 (95%CI -45.0 to -17.6), whereas the median MASI decreased by 5.4 (-9.9, -3.0) points. The first five sessions of acupuncture had a higher effect on the change in magnitude than the last five sessions, although there was no statistically significant difference. However, ten-session of acupuncture, had not reached the peak benefit on melasma yet. Further studies should be done with a higher number of sessions to determine the optimal rounds of treatment. Twenty-nine participants reported minor side effects, mostly consisting of persistent pain and small hematoma. Group B had RR of having adverse events 1.8 times (95% CI 1.0-3.4) compared to group A. Conclusion: Acupuncture has a potential dose-response effect on clinical and patient-reported melasma outcomes with minor side effects.

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“…There is evidence of oxidative stress in melasma pathogenesis. We have previously reported on a number of well‐known antioxidants that play a role in control of skin pigmentation 24 . These antioxidants include vitamin C, 25‐47 azelaic acid, 48‐52 cysteamine, 53,54 glutathione, 55‐57 carotenoids, 58,59 curcuma longa, 60,61 ellagic acid, 62,63 kojic acid, 64,65 and reservatrol 66‐69 .…”

Section: Antioxidant Therapy In Melasmamentioning

confidence: 99%

Treatment of melasma: a review of less commonly used antioxidants

Babbush

Khachemoune

2020

Int J Dermatology

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Melasma, a common cause for seeking dermatologic care, is a chronic condition of skin hyperpigmentation. With a poorly understood pathogenesis, and no universal cure, melasma is a challenge for many dermatologists. For decades, there has been investigation into the role of oxidative stress in melasma. In this literature review, we introduce the role of oxidative stress in melasma and discuss the function of various topical and oral antioxidant therapies for patients suffering from melasma. Numerous studies have shown efficacy of various antioxidant therapies for treatment of hyperpigmentation, and in this review, we focus primarily on those with less widespread use. Vitamin E, niacinamide, polypodium leucotomos, pycnogenol, grape seed extract, amino fruit acids, phytic acid, zinc, silymarin, Korean red ginseng powder, plant extracts, and parsley all have well‐demonstrated evidence of antioxidant properties, and these substances have been studied in the context of skin hyperpigmentation. Although there is conflicting evidence of their therapeutic efficacy, the use of these naturally occurring substances is promising for patients and medical providers seeking alternative therapeutic options.

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The Therapeutic Use of Antioxidants for Melasma

Cited by 40 publications

References 0 publications

Taxifolin as a Promising Ingredient of Cosmetics for Adult Skin

Taxifolin as a Promising Ingredient of Cosmetics for Adult Skin

Short Practical Regimen of Acupuncture for Melasma: A Prospective Cohort Study in a Tertiary Hospital in Thailand

Treatment of melasma: a review of less commonly used antioxidants

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