The therapeutic prospects and challenges of human neural stem cells for the treatment of Alzheimer's Disease

Yue, Chunmei; Feng, Shi Ting; Chen, Yingying; Jing, Naihe

doi:10.1186/s13619-022-00128-5

Cited by 8 publications

(5 citation statements)

References 60 publications

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“…[ 156 ] concluded that the ideal stem cell therapy for AD would transplant cells with different differentiation potentials precisely to the corresponding functional sites to achieve overall restoration of the functional network of the brain, which relies heavily on the identification and isolation of stem cell heterogeneity. [ 156 ] Besides stem cell heterogeneity, the heterogeneity of their derived cell types can greatly affect efficacy. For example, MSCs derived from healthy controls and patients can exhibit differences in certain functions.…”

Section: Challenges and Strategies For Stem Cell Technology In Ad Res...mentioning

confidence: 99%

Promoting Alzheimer’s disease research and therapy with stem cell technology

Cao,

Kong,

Ding

et al. 2024

Stem Cell Res Ther

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Background Alzheimer’s disease (AD) is a prevalent form of dementia leading to memory loss, reduced cognitive and linguistic abilities, and decreased self-care. Current AD treatments aim to relieve symptoms and slow disease progression, but a cure is elusive due to limited understanding of the underlying disease mechanisms. Main content Stem cell technology has the potential to revolutionize AD research. With the ability to self-renew and differentiate into various cell types, stem cells are valuable tools for disease modeling, drug screening, and cell therapy. Recent advances have broadened our understanding beyond the deposition of amyloidβ (Aβ) or tau proteins in AD to encompass risk genes, immune system disorders, and neuron–glia mis-communication, relying heavily on stem cell-derived disease models. These stem cell-based models (e.g., organoids and microfluidic chips) simulate in vivo pathological processes with extraordinary spatial and temporal resolution. Stem cell technologies have the potential to alleviate AD pathology through various pathways, including immunomodulation, replacement of damaged neurons, and neurotrophic support. In recent years, transplantation of glial cells like oligodendrocytes and the infusion of exosomes have become hot research topics. Conclusion Although stem cell-based models and therapies for AD face several challenges, such as extended culture time and low differentiation efficiency, they still show considerable potential for AD treatment and are likely to become preferred tools for AD research.

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Section: Challenges and Strategies For Stem Cell Technology In Ad Res...mentioning

confidence: 99%

Promoting Alzheimer’s disease research and therapy with stem cell technology

Cao,

Kong,

Ding

et al. 2024

Stem Cell Res Ther

View full text Add to dashboard Cite

show abstract

“…Another parallel between MSC and NSC is their relative effectiveness in addressing tissue repair is that NSC/NPC and MSC may be more effective in acute situations in both the brain [ 41 , 42 , 43 , 44 , 45 , 46 ] and in connective tissues such as articular cartilage [ 47 , 48 ] than in chronic disease situations involving either the brain or connective tissues [ 23 , 49 , 50 , 51 ]. The latter may relate to the in vivo environments being very different, including the involvement of a disease process involving chronic inflammation and tissue degradation fragments, and thus neither cell source may function properly in the face of a chronic inflammatory process.…”

Section: Parallels Between Nsc and Mesenchymal Stem Cells/medicinal S...mentioning

confidence: 99%

Use of Brain-Derived Stem/Progenitor Cells and Derived Extracellular Vesicles to Repair Damaged Neural Tissues: Lessons Learned from Connective Tissue Repair Regarding Variables Limiting Progress and Approaches to Overcome Limitations

Hart

2023

IJMS

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Pluripotent neural stem or progenitor cells (NSC/NPC) have been reported in the brains of adult preclinical models for decades, as have mesenchymal stem/stromal cells (MSC) been reported in a variety of tissues from adults. Based on their in vitro capabilities, these cell types have been used extensively in attempts to repair/regenerate brain and connective tissues, respectively. In addition, MSC have also been used in attempts to repair compromised brain centres. However, success in treating chronic neural degenerative conditions such as Alzheimer’s disease, Parkinson’s disease, and others with NSC/NPC has been limited, as have the use of MSC in the treatment of chronic osteoarthritis, a condition affecting millions of individuals. However, connective tissues are likely less complex than neural tissues regarding cell organization and regulatory integration, but some insights have been gleaned from the studies regarding connective tissue healing with MSC that may inform studies attempting to initiate repair and regeneration of neural tissues compromised acutely or chronically by trauma or disease. This review will discuss the similarities and differences in the applications of NSC/NPC and MSC, where some lessons have been learned, and potential approaches that could be used going forward to enhance progress in the application of cellular therapy to facilitate repair and regeneration of complex structures in the brain. In particular, variables that may need to be controlled to enhance success are discussed, as are different approaches such as the use of extracellular vesicles from stem/progenitor cells that could be used to stimulate endogenous cells to repair the tissues rather than consider cell replacement as the primary option. Caveats to all these efforts relate to whether cellular repair initiatives will have long-term success if the initiators for neural diseases are not controlled, and whether such cellular initiatives will have long-term success in a subset of patients if the neural diseases are heterogeneous and have multiple etiologies.

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“…The transplantation of neural cells derived from human iPS cells into the DG improves cognitive dysfunction in AD model mice [106], and reports have shown that neural stem cell (NSC) transplantation into the hippocampal region also improves cognitive dysfunction in AD model mice [107,108]. However, the contribution of Aβ and tau pathology in neural cell transplantation has not been fully elucidated [109][110][111][112][113].…”

Section: Nerve Regeneration In Patients With Admentioning

confidence: 99%

The past and present of therapeutic strategy for Alzheimer’s diseases: potential for stem cell therapy

Murayama

2023

Exp. Anim.

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Alzheimer's disease (AD), a progressive neurodegenerative disease characterized by cognitive dysfunction and neuropsychiatric symptoms, is the most prevalent form of dementia among the elderly. Amyloid aggregation, tau hyperphosphorylation, and neural cell loss are the main pathological features. Various hypotheses have been proposed to explain the development of AD. Some therapeutic agents have shown clinical benefits in patients with AD; however, many of these agents have failed.The degree of neural cell loss is associated with the severity of AD. Adult neurogenesis, which governs cognitive and emotional behaviors, occurs in the hippocampus, and some research groups have reported that neural cell transplantation into the hippocampus improves cognitive dysfunction in AD model mice. Based on these clinical findings, stem cell therapy for patients with AD has recently attracted attention.This review provides past and present therapeutic strategies for the management and treatment of AD.

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The therapeutic prospects and challenges of human neural stem cells for the treatment of Alzheimer's Disease

Cited by 8 publications

References 60 publications

Promoting Alzheimer’s disease research and therapy with stem cell technology

Promoting Alzheimer’s disease research and therapy with stem cell technology

Use of Brain-Derived Stem/Progenitor Cells and Derived Extracellular Vesicles to Repair Damaged Neural Tissues: Lessons Learned from Connective Tissue Repair Regarding Variables Limiting Progress and Approaches to Overcome Limitations

The past and present of therapeutic strategy for Alzheimer’s diseases: potential for stem cell therapy

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