The therapeutic potential value of Cancer-testis antigens in immunotherapy of gastric cancer

Mahmoudian, Reihaneh Alsadat; Maharati, Amirhosein; Mahmoudian, Parvaneh; Golyan, Fatemeh Fardi; Mokhlessi, Leila; Maftooh, Mina; Khazaei, Majid; Nassiri, Mohammadreza; Hassanian, Seyed Mahdi; Ghayour‐Mobarhan, Majid; Ferns, Gordon A.; Shahidsales, Soodabeh; Avan, Amir

doi:10.1016/j.gene.2022.147082

Cited by 1 publication

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References 116 publications

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“…There are more than 1 million new cases of gastric cancer every year ( 1 ). Although the treatment of gastric cancer has made great progress in recent decades, due to the limitations of various treatment methods and the characteristics of tumor recurrence and metastasis, the current treatment outcomes for gastric cancer are still unsatisfactory ( 2 ). The occurrence and development of gastric cancer is a complex process involving multiple factors and multiple steps, among which the acquisition of stem-like properties of tumor cells is closely related to the occurrence and development of gastric cancer ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

TNF+ regulatory T cells regulate the stemness of gastric cancer cells through the IL13/STAT3 pathway

et al. 2023

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Regulatory T cells (Tregs) are an important component of the tumor microenvironment; however, the interaction between Tregs and gastric cancer cells is not completely understood. Recent studies have shown that Tregs participate in cancer cell stemness maintenance. In this study, we performed single-cell RNA sequencing of gastric cancer and adjacent tissues and found that Tregs with high TNF expression were recruited to gastric cancer tissues and were significantly correlated with patient survival. TNF+ Tregs significantly contribute to tumor growth and progression. Our studies have further demonstrated that TNF+ Tregs promote the stemness of gastric cancer cells through the IL13/STAT3 pathway. Therefore, blocking the interaction between TNF+ Tregs and gastric cancer cells may be a new approach in the treatment of gastric cancer.

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Section: Introductionmentioning

confidence: 99%