The Therapeutic Potential of Stem Cells-Conditioned Media on Histologic Changes of Immune Checkpoints Inhibitor Pembrolizumab on Rats Thyroid Gland
Eman Mohamed,
Enas Abd Allah,
Samaa El-Mahroky
Abstract:Background: Immunological checkpoints inhibitor (ICI) Pembrolizumab (PEMB) is a monoclonal antibody that induces a potent antitumor immune response. Hypothyroidism and adrenal insufficiency have been associated with its addition to the therapy protocol. Conditioned media (CM) is a culture media for stem cells comprising soluble proteins, lipids, nucleic acids, and extracellular vesicles (EV). Aim of the Work: This research aimed to determine whether mesenchymal stem cells conditioned media (MSCs-CM) could amel… Show more
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