The Therapeutic Potential of Pyroptosis in Melanoma

Abstract

Pyroptosis is a programmed cell death characterized by the rupture of the plasma membranes and release of cellular content leading to inflammatory reaction. Four cellular mechanisms inducing pyroptosis have been reported thus far, including the (i) caspase 1-mediated canonical, (ii) caspase 4/5/11-mediated non-canonical, (iii) caspase 3/8-mediated and (iv) caspase-independent pathways. Although discovered as a defense mechanism protecting cells from infections of intracellular pathogens, pyroptosis plays roles in tumor initiation, progression and metastasis of tumors, as well as in treatment response to antitumor drugs and, consequently, patient outcome. Pyroptosis induction following antitumor therapies has been reported in several tumor types, including lung, colorectal and gastric cancer, hepatocellular carcinoma and melanoma. This review provides an overview of the cellular pathways of pyroptosis and discusses the therapeutic potential of pyroptosis induction in cancer, particularly in melanoma.

Kaempferol-induced mitochondrial damage promotes NF-κB-NLRP3-caspase-1 signaling axis-mediated pyroptosis in gastric cancer cells

“…Among various factors influencing GC progression, cell death holds significant importance [ 27 ]. Pyroptosis, an inflammatory programmed cell death process, is pivotal in the initiation of tumors, the advancement of various diseases, and the facilitation of cancer spread and metastasis [ 30 ].…”

Kaempferol-induced mitochondrial damage promotes NF-κB- NLRP3-caspase-1 signaling axis-mediated pyroptosis in gastric cancer cells

“…Among various factors in uencing gastric cancer progression, cell death holds signi cant importance (Wang, Liu et al 2022) . Pyroptosis, a form of programmed cell death, plays a crucial role in tumorigenesis, disease progression, and metastasis (Zaffaroni and Beretta 2023).…”

Research progress on molecular mechanism of pyroptosis caused by Helicobacter pylori in gastric cancer

“…In the later stage of tumour treatment, it is closely related to tumour cell resistance and the outcome of patients. According to the different activation molecules of caspase, it can be divided into caspase-1 regulating the classical pathway, caspase-4/5/11 regulating the non-classical pathway, caspase-3/8 regulating pathway, and caspase-independent regulating pathway 30 . The specific pathway of cell pyroptosis mainly involves the assembly of external or internal danger signal molecules (mainly NLRP series protein receptors, AIM2 proteins, etc.)…”