The therapeutic potential of Houttuynia cordata: A current review

Laldinsangi, C.

doi:10.1016/j.heliyon.2022.e10386

Cited by 11 publications

(6 citation statements)

References 99 publications

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“…Some of the TCM herbs in NRICM101 have anti-inflammatory effects, such as H. cordata and I. indigotica [ 39 , 40 ]; some have antioxidant effects, such as mulberry leaf [ 41 ]. Specifically, S. baicalensis exerts antiviral effects by inhibiting the activation of 3C-like protease (3CLpro) and the replication of SARS-CoV-2 [ 22 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

“…Thus, this study aimed to explore the more effective components in the TCM used to treat SARS-CoV-2 variants by targeting the interaction between mutated spike proteins and hACE2. Some of the TCM herbs in NRICM101 have anti-inflammatory effects, such as H. cordata and I. indigotica [39,40]; some have antioxidant effects, such as mulberry leaf [41]. Specifically, S. baicalensis exerts antiviral effects by inhibiting the activation of 3C-like protease (3CLpro) and the replication of SARS-CoV-2 [22,42].…”

Section: Discussionmentioning

confidence: 99%

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Inhibitory Efficacy of Main Components of Scutellaria baicalensis on the Interaction between Spike Protein of SARS-CoV-2 and Human Angiotensin-Converting Enzyme II

Lin,

Chang,

Lin

et al. 2024

IJMS

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Blocking the interaction between the SARS-CoV-2 spike protein and the human angiotensin-converting enzyme II (hACE2) protein serves as a therapeutic strategy for treating COVID-19. Traditional Chinese medicine (TCM) treatments containing bioactive products could alleviate the symptoms of severe COVID-19. However, the emergence of SARS-CoV-2 variants has complicated the process of developing broad-spectrum drugs. As such, the aim of this study was to explore the efficacy of TCM treatments against SARS-CoV-2 variants through targeting the interaction of the viral spike protein with the hACE2 receptor. Antiviral activity was systematically evaluated using a pseudovirus system. Scutellaria baicalensis (S. baicalensis) was found to be effective against SARS-CoV-2 infection, as it mediated the interaction between the viral spike protein and the hACE2 protein. Moreover, the active molecules of S. baicalensis were identified and analyzed. Baicalein and baicalin, a flavone and a flavone glycoside found in S. baicalensis, respectively, exhibited strong inhibitory activities targeting the viral spike protein and the hACE2 protein, respectively. Under optimized conditions, virus infection was inhibited by 98% via baicalein-treated pseudovirus and baicalin-treated hACE2. In summary, we identified the potential SARS-CoV-2 inhibitors from S. baicalensis that mediate the interaction between the Omicron spike protein and the hACE2 receptor. Future studies on the therapeutic application of baicalein and baicalin against SARS-CoV-2 variants are needed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Inhibitory Efficacy of Main Components of Scutellaria baicalensis on the Interaction between Spike Protein of SARS-CoV-2 and Human Angiotensin-Converting Enzyme II

Lin,

Chang,

Lin

et al. 2024

IJMS

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“…It is also effective for refractory haemoptysis, pneumonia, infectious disease and malignant pleural effusion treatments (Shingnaisui et al ., 2018). The high flavonoid and terpenoid contents in the plant are among the most integral constituents that enhance its broad medicinal and pharmacological effects, such as antiviral, anti‐obesity, anti‐diabetic, antimutagenic, anti‐inflammatory, antioxidative, anti‐hyperglycaemic, antibacterial and immune‐suppressive, among others (Wu et al ., 2021; Laldinsangi, 2022).…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of silver nanoparticles using Houttuynia cordata Thunb rhizome extracts and their antibacterial potential against common foodborne pathogens

Maimaiti,

Bassey,

Liu

et al. 2024

Int J of Food Sci Tech

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SummaryThe biological synthesis of functionalised nanoparticles using plant materials is considered more cost‐effective and eco‐friendly than chemical and physical methods. Hence, this study demonstrated the synthesis of silver nanoparticles (AgNPs) using Houttuynia cordata Thunb rhizome (HCR). The extract, prepared with distilled water, provided the required phytochemical components, such as flavonoids, terpenoids, phenols, proteins and other essential bio‐reducing agents. The AgNPs were exposed to reaction conditions, such as temperatures, pH values and AgNO3 concentrations, to identify the optimum synthesis condition and explore their impacts on particle size and antibacterial action against Gram‐positive (Staphylococcus aureus) and Gram‐negative (Salmonella enterica and Shigella dysenteriae) foodborne pathogens. The formation of AgNPs was indicated by specific surface plasmon resonance (SPR) intensity at 440–450 nm and colour changes under different reaction conditions. The structure and size distribution characterised by SEM and TEM revealed that the AgNPs exhibited a spherical‐shaped structure with irregular contours, regular distribution and aggregation. Although the average particle size ranged from 2 to 100 nm, relatively smaller sizes were detected at 10 mM (54.30), 80 °C (49.50 nm) and pH 6 (60.16 nm) conditions. The FTIR spectrum and EDX spectral signals affirmed the presence of reducing and stabilising agents in HCR extract, following the reduction of AgNPs from Ag+ to Ag0. AgNPs also exhibited excellent antibacterial activity against S. aureus, S. enterica and Sh. dysenteriae, indicating a broad spectrum for various applications in the food and pharmaceutical industries.

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“…Pharmaceuticals derived from plants are extraordinarily abundant and provide superior benefits over synthetic substances in terms of variety, volume of production, and safety [1]. Important pharmaceuticals that are widely used in modern medicine include vinca alkaloids, artemisinin, chloroquine, and morphine.…”

Section: Introductionmentioning

confidence: 99%

“…The hunt for novel bioactive compounds derived from plants is never-ending and remains a crucial source of potent medicinal compounds [2]. One such plant, Houttuynia cordata, a perennial and herbaceous plant native to East Asian countries and a member of the Family "Saururaceae", received particular focus owing to its possible antiviral properties, particularly in light of the recent COVID-19 pandemic [1,3]. Several studies have documented its pharmacological activity against various conditions, including cancer [4], viruses [5], obesity, hyperglycemia [6], and inflammation [7,8].…”

Section: Introductionmentioning

confidence: 99%

Evaluating Antioxidant Performance, Biosafety, and Antimicrobial Efficacy of Houttuynia cordata Extract and Microwave-Assisted Synthesis of Biogenic Silver Nano-Antibiotics

Moorthy,

Chang,

Huang

et al. 2023

Antioxidants

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From the traditional Chinese medicine point of view, although Houttuynia cordata extract (HCE) possesses an incredible amount of phytonutrients and exhibits antioxidant activities, excessive doses of HCE can cause danger to organisms and lead to death. In this study, we first examine HCE’s overall phenolic and flavonoid content, antioxidant efficacy, and antibacterial activity. Results show that HCE is suitable as a bio-reducing agent for the microwave-assisted synthesis of silver nanoparticles (HCE-AgNPs) with enhanced antioxidant and antimicrobial performance. Under an optimized microwave condition (i.e., 100 °C for 10 min), the HCE-stabilized AgNPs were confirmed with a UV-visible peak at 430 nm and 19.7 ± 4.2 nm in size. Physicochemical properties of HCE-AgNPs were extensively characterized by zeta-potential, FT-IR, XRD, and XPS measurements. Compared to the HC extract counterpart, HCE-AgNPs display superior antioxidant activity, higher DPPH scavenging efficiency, and enhanced broad-spectrum bactericidal activity to inhibit the growth of all tested bacterial strains at doses of 2 μg/mL. Biosafety evaluation indicated that HCE-AgNPs are noncytotoxic on human red blood cells. These data show that the microwave synthesis of AgNPs exhibits a great antioxidant ability, superior antibacterial activity, and a trivial hemolytic effect, providing another bactericidal therapy strategy to address the increasing healthcare-associated infections.

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The therapeutic potential of Houttuynia cordata: A current review

Cited by 11 publications

References 99 publications

Inhibitory Efficacy of Main Components of Scutellaria baicalensis on the Interaction between Spike Protein of SARS-CoV-2 and Human Angiotensin-Converting Enzyme II

Inhibitory Efficacy of Main Components of Scutellaria baicalensis on the Interaction between Spike Protein of SARS-CoV-2 and Human Angiotensin-Converting Enzyme II

Green synthesis of silver nanoparticles using Houttuynia cordata Thunb rhizome extracts and their antibacterial potential against common foodborne pathogens

Evaluating Antioxidant Performance, Biosafety, and Antimicrobial Efficacy of Houttuynia cordata Extract and Microwave-Assisted Synthesis of Biogenic Silver Nano-Antibiotics

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