The therapeutic potential of curcumin and its related substances in turmeric: From raw material selection to application strategies

Hsu, K. L.; Ho, Chi‐Tang; Pan, Min‐Hsiung

doi:10.38212/2224-6614.3454

Cited by 13 publications

(13 citation statements)

References 186 publications

(220 reference statements)

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“…Beyond its culinary use, turmeric has historically been used in Chinese and Indian traditional medicine for treating various diseases and conditions. Curcumin-a polyphenol and the active component of turmeric-has been extensively studied in recent decades, demonstrating its potential antioxidant, anti-inflammatory, anti-diabetes, and anticancer effects [114]. A systematic review and meta-analysis of 64 RCTs found that turmeric/curcumin supplementation was effective in improving blood levels of TC, TG, LDL-c, and HDL-c [115].…”

Section: Polyphenol-rich Plant Foodsmentioning

confidence: 99%

Diet strategies for promoting healthy aging and longevity: An epidemiological perspective

2023

J Intern Med

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In recent decades, global life expectancies have risen significantly, accompanied by a marked increase in chronic diseases and population aging. This narrative review aims to summarize recent findings on the dietary factors influencing chronic diseases and longevity, primarily from large cohort studies. First, maintaining a healthy weight throughout life is pivotal for healthy aging and longevity, mirroring the benefits of lifelong, moderate calorie restriction in today's obesogenic food environment. Second, the specific types or food sources of dietary fat, protein, and carbohydrates are more important in influencing chronic disease risk and mortality than their quantity. Third, some traditional diets (e.g., the Mediterranean, Nordic, and Okinawa) and contemporary dietary patterns, such as healthy plant‐based diet index, the DASH (dietary approaches to stop hypertension) diet, and alternate healthy eating index, have been associated with lower mortality and healthy longevity. These patterns share many common components (e.g., a predominance of nutrient‐rich plant foods; limited red and processed meats; culinary herbs and spices prevalent in global cuisines) while embracing distinct elements from different cultures. Fourth, combining a healthy diet with other lifestyle factors could extend disease‐free life expectancies by 8–10 years. While adhering to core principles of healthy diets, it is crucial to adapt dietary recommendations to individual preferences and cultures as well as nutritional needs of aging populations. Public health strategies should aim to create a healthier food environment where nutritious options are readily accessible, especially in public institutions and care facilities for the elderly. Although further mechanistic studies and human trials are needed to better understand molecular effects of diet on aging, there is a pressing need to establish and maintain long‐term cohorts studying diet and aging in culturally diverse populations.

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Section: Polyphenol-rich Plant Foodsmentioning

confidence: 99%

Diet strategies for promoting healthy aging and longevity: An epidemiological perspective

2023

J Intern Med

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“…2 It has a wide range of applications apart from dietary supplements, namely, in the food industry (colorant and preservative), cosmetics manufacturing, 13 and textile manufacturing (dyeing). 14 However, curcumin's limited absorption in the stomach leads to nonsignificant levels in the bloodstream which affects its wide usage as a lead compound. 15 This is because of its poor oral bioavailability, poor solubility, and hydrophobicity.…”

Section: Introductionmentioning

confidence: 99%

“…It also acts as an immune modulator, metabolism regulator, neuroprotector, and tissue protector . It has a wide range of applications apart from dietary supplements, namely, in the food industry (colorant and preservative), cosmetics manufacturing, and textile manufacturing (dyeing) …”

Section: Introductionmentioning

confidence: 99%

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Curcumin-Conjugated PAMAM Dendrimers of Two Generations: Comparative Analysis of Physiochemical Properties Using Adriatic Topological Indices

D. S.,

Julietraja,

Jaganathan

et al. 2024

ACS Omega

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Curcumin (C 21 H 20 O 6 ) is a polyphenol found in the plant Curcuma longa. Even though it possesses many pharmacological effects, owing to its limited intestinal absorption, solubility, and oral bioavailability, it is more often used as a health supplement than as a lead chemical. The poly(amido)amine (PAMAM) dendrimer (nanostructure) is utilized to enhance the stability and targeted delivery of drugs. Recently, curcumin was conjugated with the PAMAM dendrimer and analyzed for its photostability. Further investigation into the physiochemical characteristics of different generations can facilitate curcumins' targeted delivery for many diseases, including cancer. However, many of these conjugates' physiochemical properties are not available in databases since they have not been explored theoretically or experimentally. In this article, QSAR/QSPR (quantitative structure−activity relationship/quantitative structure−property relationship) analysis of physiochemical properties was carried out for component structures, which produced encouraging results. Hence, 16 discrete adriatic topological indices and their associated entropy measures were evaluated to theoretically predict a few physiochemical properties of the conjugated structure. The predictions will aid the chemist in drug designing.

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“…The novel therapeutic agent GZ17-6.02 (602) is comprised of three synthetically manufactured natural compounds in the following ratio: isovanillin (77%), harmine (13%) and curcumin (10%) [ 11 ]. Curcumin as a single agent has low solubility in water, has very poor PK/PD in vivo and failed in the clinic as an anti-cancer agent [ 12 , 13 ]. In our prior in vitro studies using low physiologic concentrations of curcumin, the generation of reactive oxygen species played an important role in the process by which tumor cells were killed [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

GZ17-6.02 interacts with proteasome inhibitors to kill multiple myeloma cells

Booth,

Roberts,

West

et al. 2024

Oncotarget

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GZ17-6.02, a synthetically manufactured compound containing isovanillin, harmine and curcumin, has undergone phase I evaluation in patients with solid tumors (NCT03775525) with a recommended phase 2 dose (RP2D) of 375 mg PO BID. GZ17-6.02 was more efficacious as a single agent at killing multiple myeloma cells than had previously been observed in solid tumor cell types. GZ17-6.02 interacted with proteasome inhibitors in a greater than additive fashion to kill myeloma cells and alone it killed inhibitor-resistant cells to a similar extent. The drug combination of GZ17-6.02 and bortezomib activated ATM, the AMPK and PERK and inactivated ULK1, mTORC1, eIF2α, NFκB and the Hippo pathway. The combination increased ATG13 S318 phosphorylation and the expression of Beclin1, ATG5, BAK and BIM, and reduced the levels of BCL-XL and MCL1. GZ17-6.02 interacted with bortezomib to enhance autophagosome formation and autophagic flux, and knock down of ATM, AMPKα, ULK1, Beclin1 or ATG5 significantly reduced both autophagy and tumor cell killing. Knock down of BAK and BIM significantly reduced tumor cell killing. The expression of HDACs1/2/3 was significantly reduced beyond that previously observed in solid tumor cells and required autophagy. This was associated with increased acetylation and methylation of histone H3. Combined knock down of HDACs1/2/3 caused activation of ATM and the AMPK and caused inactivation of ULK1, mTORC1, NFκB and the Hippo pathway. HDAC knock down also enhanced ATG13 phosphorylation, increased BAK levels and reduced those of BCL-XL. Collectively, our present studies support performing additional in vivo studies with multiple myeloma cells.

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The therapeutic potential of curcumin and its related substances in turmeric: From raw material selection to application strategies

Cited by 13 publications

References 186 publications

Diet strategies for promoting healthy aging and longevity: An epidemiological perspective

Diet strategies for promoting healthy aging and longevity: An epidemiological perspective

Curcumin-Conjugated PAMAM Dendrimers of Two Generations: Comparative Analysis of Physiochemical Properties Using Adriatic Topological Indices

GZ17-6.02 interacts with proteasome inhibitors to kill multiple myeloma cells

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