The therapeutic potential of curcumin: A review of clinical trials

Salehi, Bahare; Stojanović-Radić, Zorica; Matejić, Jelena S.; Sharifi‐Rad, Mehdi; N, Anil Kumar; Martins, Natália; Sharifi‐Rad, Javad

doi:10.1016/j.ejmech.2018.12.016

Cited by 372 publications

(284 citation statements)

References 109 publications

Supporting

Mentioning

279

Contrasting

Unclassified

Order By: Relevance

“…A raising number of pre-and clinical studies have investigated CUR effects in CVD that is mainly put down to its antihyperlipidemic and anti-atherosclerotic properties [18]. In clinical trials, CUR was used in different doses ranging from 20-4000 mg with different effects on CV biochemical parameters [18].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases

Salehi

Prado-Audelo

Cortés

et al. 2020

JCM

Self Cite

View full text Add to dashboard Cite

Cardiovascular diseases (CVD) compromises a group of heart and blood vessels disorders with high impact on human health and wellbeing. Curcumin (CUR) have demonstrated beneficial effects on these group of diseases that represent a global burden with a prevalence that continues increasing progressively. Pre-and clinical studies have demonstrated the CUR effects in CVD through its anti-hypercholesterolemic and anti-atherosclerotic effects and its protective properties against cardiac ischemia and reperfusion. However, the CUR therapeutic limitation is its bioavailability. New CUR nanomedicine formulations are developed to solve this problem. The present article aims to discuss different studies and approaches looking into the promising role of nanotechnology-based drug delivery systems to deliver CUR and its derivatives in CVD treatment, with an emphasis on their formulation properties, experimental evidence, bioactivity, as well as challenges and opportunities in developing these systems.

show abstract

Section: Introductionmentioning

confidence: 99%

Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases

Salehi

Prado-Audelo

Cortés

et al. 2020

JCM

Self Cite

View full text Add to dashboard Cite

show abstract

“…2) is a yellow-coloured compound extracted from the rhizome of Curcuma longa L. (turmeric). CUR has been employed as a culinary spice and for the treatment of various diseases, including skin disorders and wound healing, dating back to 4000 years ago 108 . CUR decreased UVB-induced oxidative stress, inflammation and DNA damage in vitro 109 and in vivo 110 .…”

Section: Curcuminmentioning

confidence: 99%

Ultraviolet A protective potential of plant extracts and phytochemicals

2020

View full text Add to dashboard Cite

Chronic exposure to solar radiation is related to an increased incidence of various skin disorders, including premature skin aging and melanoma and non-melanoma skin cancers. Ultraviolet (UV) photons in particular are responsible for skin damage. Solar UV photons mainly belong to UVA wavebands, however UVA radiation has been mostly ignored for a long time. At the cellular level, UVA photons mainly provoke indirect oxidative damage to biomolecules via the massive generation of unstable and highly reactive compounds. Human skin has several effective mechanisms that forestall, repair and eliminate damage caused by solar radiation. Regardless, some damage persists and can accumulate with chronic exposure. Therefore, conscious protection against solar radiation (UVB+UVA) is necessary. Besides traditional types of photoprotection such as sunscreen use, new strategies are being searched for and developed. One very popular protective strategy is the application of phytochemicals as active ingredients of photoprotection preparations instead of synthetic chemicals. Phytochemicals usually possess additional biological activities besides absorbing the energy of photons, and those properties (e.g. antioxidant, anti-inflammatory) magnify the protective potential of phytochemicals and extracts. Therefore, compounds of natural origin are in the interest of researchers as well as developers. In this review, only studies on UVA protection with well-documented experimental conditions are summarized. This article includes 17 well standardized plant extracts (Camellia sinensis (L.) Kuntze, Silybum marianum L. Gaertn., Punica granatum L., Polypodium aureum L., Vaccinium myrtillus L., Lonicera caerulea L., Thymus vulgaris L., Opuntia ficus-indica (L.) Mill., Morinda citrifolia L., Aloe vera (L.) Burm.f., Oenothera paradoxa Hudziok, Galinsoga parviflora Cav., Galinsoga quadriradiata Ruiz et Pavón, Hippophae rhamnoides L., Cola acuminata Schott & Endl., Theobroma cacao L. and Amaranthus cruentus L.) and 26 phytochemicals.

show abstract

“…However, most are phytochemicals (for example, sulforaphane comes from broccoli, resveratrol from grapes, tadehaginoside from Tadehagi triquetrum, curcumin from Curcuma longa plants, piperlongumine from Piper longum, and butein from the Japanese lacquer tree), metabolites and/or nutrients obtained from diet (olive oil included) or dietary supplements (Baeeri et al, 2019;Dinkova-Kostova, Fahey, Kostov, & Kensler, 2017;Dodson et al, 2019;Iranshahy et al, 2018;Nwanodi, 2018;Rigacci & Stefani, 2016;Vega et al, 2016;Wu et al, 2018). To achieve quantifiable therapeutic concentrations in the body, a select few were formulated and channeled through clinical trials for more rigorous evaluation (Ahmed, Luo, Namani, Wang, & Tang, 2017;Al-Sawaf et al, 2015;Cuadrado et al, 2019;Dinkova-Kostova et al, 2018;Dodson et al, 2019;Salehi et al, 2019;Vega et al, 2016). Thus far, the dimethyl ester of fumaric acid is the only one to emerge with approval for clinical use-branded as Fumaderm ® (Germany) in the treatment of psoriasis (Al-Jaderi & Maghazachi, 2016;Al-Sawaf et al, 2015;Cuadrado et al, 2019;Mrowietz et al, 2018;Rizvi et al, 2015) and Tecfidera ® (USA, Europe) for multiple sclerosis (Cuadrado et al, 2019;Dinkova-Kostova et al, 2018;Dodson et al, 2019;Mrowietz et al, 2018;Vega et al, 2016).…”

Section: Nrf2-activating Therapeuticsmentioning

confidence: 99%

Epigenetic treatment of dermatologic disorders

Moos

Faller

Glavas

et al. 2019

Drug Development Research

View full text Add to dashboard Cite

Healthy skin protects us against a multitude of insults, but injured or maladapted skin can lead to infection, inflammation, or worse. Fortunately, naturally occurring bioactive products, many commonly found in olive oil and other plant and vegetable extracts, have shown utility in treating skin and related diseases as well as conditioning the skin to maintain its healthy function. Powerful agents targeting nuclear regulatory pathways continue to hold promise as new or repurposed therapies for a wide variety of ills and skin conditions. Epigenetic approaches that activate Nrf2 to effect detoxification, redox balance, DNA repair, and mitochondrial function are noteworthy. Some of the disease applications being actively investigated range from eczema and psoriasis to skin cancer and diabetes‐related wound healing to name just a few.

show abstract

The therapeutic potential of curcumin: A review of clinical trials

Cited by 372 publications

References 109 publications

Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases

Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases

Ultraviolet A protective potential of plant extracts and phytochemicals

Epigenetic treatment of dermatologic disorders

Contact Info

Product

Resources

About