The therapeutic potential of cannabinoids for integumentary wound management

Weigelt, Maximillian A.; Sivamani, Raja K; Lev‐Tov, Hadar

doi:10.1111/exd.14241

Cited by 19 publications

(13 citation statements)

References 83 publications

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“…[38][39][40][41] Stem cells from the basal layer of the epithelium along with the bulge component of hair follicles are largely responsible for re-epithelialization of wounds emanating from wound margins. 64 A recent human in vitro study, using human scalp hair follicles, demonstrated stimulation of epithelial stem cells that was due to CB1 mediated signalling through both MAPK and TA B L E 5 Summary of wound surface area, rate of wound healing and time required to achieve complete wound closure in all patients a Excluding three wounds that were lost to follow-up.…”

Section: Discussionmentioning

confidence: 99%

“…Through their capacity to interact with nuclear receptors such as the PPAR family, cannabinoids may also potentially promote wound healing through epigenetic mechanisms 38–41 . Stem cells from the basal layer of the epithelium along with the bulge component of hair follicles are largely responsible for re‐epithelialization of wounds emanating from wound margins 64 . A recent human in vitro study, using human scalp hair follicles, demonstrated stimulation of epithelial stem cells that was due to CB1 mediated signalling through both MAPK and Akt pathways 66 .…”

Section: Discussionmentioning

confidence: 99%

“…59,60 The anti-inflammatory properties of cannabinoids may operate through their ability to reduce levels of TNFα, reactive oxygen species and lipoxygenases. [60][61][62][63][64] Furthermore, cannabinoids also possess the capacity to improve tissue perfusion and oxygenation via direct vasodilation. 65 After the state of hyper-inflammation has been modulated, the processes related to proliferation of granulation tissue, angiogenesis and cellular differentiation commence.…”

Section: Discussionmentioning

confidence: 99%

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Topical cannabis‐based medicines – A novel adjuvant treatment for venous leg ulcers: An open‐label trial

Maida

Shi

Fazzari

et al. 2021

Experimental Dermatology

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Venous leg ulcers are highly prevalent lower limb integumentary wounds that remain challenging to heal despite the use of evidence-based compression therapies. A multitude of adjuvant treatments has been studied but none have demonstrated enough efficacy to gain adoption into treatment guidelines. Global attention on Cannabis-Based Therapies is increasing and has been driven by quantum scientific advancements in the understanding of the endocannabinoid signalling system. Topical Cannabis-Based Medicines represent a novel treatment paradigm for venous leg ulcers in terms of promoting wound closure. Fourteen complex patients with sixteen recalcitrant leg ulcers were treated with Topical Cannabis-Based Medicines in conjunction with compression bandaging, every second day, to both wound bed and peri-wound tissues.The cohort had a mean age of 75.8 years and was medically complex as reflected by a mean M3 multimorbidity index score of 2.94 and a mean Palliative Performance Scale score of 67.1%. Complete wound closure, defined as being fully epithelialized, was achieved among 11 patients (79%) and 13 wounds (81%) within a median of 34 days.All three remaining patients demonstrated progressive healing trends but were lost to follow-up. The treatments were well tolerated, and no significant adverse reactions were experienced. The rapid wound closure of previously non-healing venous leg ulcers among elderly and highly complex patients suggests that Topical Cannabis-Based Medicines may become effective adjuvants in conjunction with compression therapy. This may also indicate that they may have an even broader role within integumentary and wound management. Therefore, this treatment paradigm warrants being subjected to controlled trials.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Topical cannabis‐based medicines – A novel adjuvant treatment for venous leg ulcers: An open‐label trial

Maida

Shi

Fazzari

et al. 2021

Experimental Dermatology

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“…CBC shows antinociceptive an anti-inflammatory effects, and in vivo it potentiates some effects of THC [12]. CBG h antibacterial, antiproliferative, and bone-stimulant properties [13][14][15], whereas CBN is o tained by oxidation of THC in air and stimulates feeding in rats [16]. Finally, THCV h anorexic and antiepileptic effects, and it may be clinically effective to treat migraine [17 Besides cannabinoids, terpenes and phenolic compounds are also present in cannab extracts, and may bring health benefits.…”

Section: Introductionmentioning

confidence: 99%

In Silico and In Vitro Analysis of Major Cannabis-Derived Compounds as Fatty Acid Amide Hydrolase Inhibitors

et al. 2020

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Accumulated evidence suggests that enhancing the endocannabinoid (eCB) tone, in particular of anandamide (N-arachidonoylethanolamine, AEA), has therapeutic potential in many human diseases. Fatty acid amide hydrolase (FAAH) is a membrane-bound enzyme principally responsible for the degradation of AEA, and thus it represents a relevant target to increase signaling thereof. In recent years, different synthetic and natural compounds have been developed and tested on rat FAAH, but little is known of their effect on the human enzyme. Here, we sought to investigate six major cannabis-derived compounds to compare their action on rat and human FAAHs. To this aim, we combined an in silico analysis of their binding mode and affinity, with in vitro assays of their effect on enzyme activity. This integrated approach allowed to disclose differences in efficacy towards rat and human FAAHs, and to highlight the role of key residues involved in the inhibition of both enzymes. This study suggests that the therapeutic efficacy of compounds targeted towards FAAH should be always tested in vitro on both rat and human enzymes.

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“…It is important to emphasize that multiple chemical compounds play roles in the medicinal benefits of cannabis through their complex interactions with the endocannabinoid signaling system. 2 The authors misrepresented some of the available literature by identifying cannabidiol (CBD) as the principal mediator of beneficial impact. They reference the 2017 systematic review by the National Academies of Sciences, Engineering, and Medicine on the therapeutic applications of cannabinoids.…”

mentioning

confidence: 99%