The Therapeutic Options in Childhood Epilepsy: From Pharmaceuticals to Nutraceuticals

Abstract

Epilepsy is one of the most common neurological disorders of childhood. Treatment of epileptic seizures is governed by weighing the benefit-risk of using anti-epileptic drugs. An important limitation of their use is that, in at least one third of patients, seizures are resistant to the available older and new-generation anti-epileptic drugs. This challenge makes the non-pharmacologic mode of treatment an attractive option. With the global demonstration of the therapeutic benefits of the ketogenic diet signaling a possible paradigm shift, evaluating its risk profile will help to establish its benefit-risk ratio. Multifaceted side effects of the diet have been reported in several studies but have not precluded its use. To promote its world-wide acceptability, its components should be modified to include locallyavailable food stuffs. The present review aims to highlight and compare the benefit-risk ratio of using anti-epileptic drugs and the ketogenic diet in the treatment of refractory childhood epilepsy.

Nanotechnology - A Path to a Sustainable Future

“…With the aid of making use of the new standards and engineering methods concerned in nanomaterials to target the shipping of bioactive compounds and micronutrients [78][79][80] . Nanomaterials permit higher encapsulation and launch performance of the active meals ingredients in comparison to traditional encapsulating sellers, and the development of nano-emulsions, liposomes, micelles, biopolymer [81][82][83] complexes and cubosomes have caused progressed houses for bioactive compounds protection, managed transport structures, meals matrix integration, and covering undesired flavors.…”