The therapeutic effects of Ficus carica extract as antioxidant and anticancer agent

Abdel-Rahman, Raoufa; Ghoneimy, Eglal A.; Abdelwahab, Abeer E.; El‐Deeb, Nehal M.; Salem, Marwa S.; Salama, Eman H; Ahmed, Talaat

doi:10.1016/j.sajb.2021.04.019

Cited by 21 publications

(14 citation statements)

References 24 publications

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“…The most important secondary metabolite in F. carica is psoralen [3]. Because of its strong physiological activity, F. carica is considered to have anti-bacterial, anti-viral, anti-tumor, and blood sugar lowering effects [4,5]. F. carica is cultivated widely in China, primarily distributed in Xinjiang, Fujian, Shandong, and other places.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Interplanting of Ficus carica L. with Taxus cuspidata Sieb. et Zucc. on Growth of Two Plants

Yang

et al. 2021

Agriculture

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Medicinal-agroforestry systems are one of the multi-functional medicinal plant production systems, gaining attention as a sustainable alternative to traditional monoculture systems. In this study, three planting patterns were established which included: (1) monoculture F. carica (MF); (2) monoculture T. cuspidata (MT); and (3) interplanting F. carica with T. cuspidata (IFT). The differences of growth biomass, photosynthesis, soil nutrients, soil enzyme activities, soil microorganisms, and main secondary metabolites of F. carica and T. cuspidata under the above three models were investigated. Compared with the MF and MT patterns, IFT pattern for 5 months significantly increased the plant growth biomass, photosynthesis, soil organic carbon, total nitrogen, and secondary metabolites content. The activities of acid phosphatase, sucrase, protease, polyphenol oxidase, urease, dehydrogenase, and catalase in soil of IFT were significantly higher than MF and MT patterns. Results showed that IFT pattern is preferred compared to the MF and MT patterns. Our result will help to provide a feasible theoretical basis for the large-scale establishment of F. carica and T. cuspidata mixed forests and obtain high-quality medicine sources for extracting important active ingredients, psoralen and paclitaxel, which are crucial to the long-term sustainable development and production of medicinal plants.

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Section: Introductionmentioning

confidence: 99%

Enhancement of Interplanting of Ficus carica L. with Taxus cuspidata Sieb. et Zucc. on Growth of Two Plants

Yang

et al. 2021

Agriculture

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“…The ethanolic and acetone extract of the leaves from F. carica showed inhibition of the viability of different cell lines (Abdel-Rahman et al, 2021;Mustafa et al, 2021). These results also demonstrated a relation between anti-tumour properties and antioxidant activity, which is in turn caused by the inhibition of certain enzymes, including tyrosinase and α-glucosidase (Meziant et al, 2021).…”

Section: Anti-tumor and Immunomodulatory Propertiesmentioning

confidence: 65%

“…The Figs are an excellent source of different biologically active biomolecules and are responsible for a wide range of bioactive effects: antioxidant, anti-inflammatory, anticancer, antimicrobial, anti-ageing, and wound healing effects (Abdel-Rahman et al, 2021;Boyacıoglu et al, 2021). The main bioactive molecules present in various fig and fig by-products are terpenoids, carotenoids, phytosterols, volatile organic compounds, phenolic acids, and flavonoids, including anthocyanins, flavonols, flavan-3-ols, and flavanones (Pereira et al, 2017).…”

Section: Extraction Separation and Refinement Of Fig Biomoleculesmentioning

confidence: 99%

“…Ageing is a natural process that can be intrinsic and associated with specific genes, signalling pathways, and certain antioxidant mechanisms (Cȃtanȃ et al, 2018). In this sense, even though there are no specific studies on this property for F. carica, the wide variety of reports about the antioxidant potential and related properties makes it feasible to extrapolate that its by-products could be a source of potential anti-ageing metabolicompounds (Abdel-Rahman et al, 2021;Ali et al, 2012;Irudayaraj et al, 2016Irudayaraj et al, , 2017Meziant et al, 2021;Mustafa et al, 2021). In the case of wound healing, a recent study showed a reduced dose-dependent migration in cells treated with F. carica latex, showing an anti-metastatic effect (AlGhalban et al, 2021).…”

Section: Anti-ageing Wound Healing and Antimicrobial Propertiesmentioning

confidence: 99%

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Fig “Ficus carica L.” and its by-products: A decade evidence of their health-promoting benefits towards the development of novel food formulations

Ayuso

Carpena

Taofiq

et al. 2022

Trends in Food Science & Technology

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“…Fig has not only a wide range of medicinal and nutritional values, but also nourishes the stomach and clears the intestines, reducing swelling and detoxification. It is often used in the treatment of anorexia, abdominal distension and abdominal pain, hemorrhoids and constipation, dyspepsia, insufficient milk, sore throat, cough, and sputum [3][4][5].…”

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confidence: 99%

Valorization of Fig (Ficus carica L.) Waste Leaves: HPLC-QTOF-MS/MS-DPPH System for Online Screening and Identification of Antioxidant Compounds

Шен

et al. 2021

Plants

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Fig (Ficus carica L.) leaves are produced each year and often disposed, resulting in a waste of resources. Fig waste leaves are rich in flavonoids, which have strong antioxidant activity; however, the variety and chemical structure of antioxidants in fig leaves have not been reported in detail. To take full advantage of fig waste leaves, antioxidant capacity of different extracts (petroleum ether, ethyl acetate, and water) was evaluated by 1, 1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic) acid (ABTS), and ferric-ion-reducing antioxidant power (FRAP) methods. The results showed that flavonoids in ethyl acetate extraction had the highest content (83.92 ± 0.01 mg/g), maximum DPPH scavenging activity (IC50 0.54 mg/mL), highest ABTS scavenging rate (80.28%), and FRAP (3.46 mmol/g). Furthermore, an HPLC-QTOF-MS/MS-DPPH method was developed to identify 11 flavonoids in fig waste leaves. This rapid and efficient method can not only be used for screening the antioxidant components in fig waste leaves, but also can be combined with mass spectrometry to identify the compounds with antioxidant capacity. There are three flavonoids with significant antioxidant capacity, which are 3-O-(rhamnopyranosyl-glucopyranosyl)-7-O-(glucopyranosyl)-quercetin, isoschaftoside, and rutin. The results confirmed that fig waste leaves contain a variety of antioxidant components, which contributed to increase the value of fig waste leaves as antioxidants.

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The therapeutic effects of Ficus carica extract as antioxidant and anticancer agent

Cited by 21 publications

References 24 publications

Enhancement of Interplanting of Ficus carica L. with Taxus cuspidata Sieb. et Zucc. on Growth of Two Plants

Enhancement of Interplanting of Ficus carica L. with Taxus cuspidata Sieb. et Zucc. on Growth of Two Plants

Fig “Ficus carica L.” and its by-products: A decade evidence of their health-promoting benefits towards the development of novel food formulations

Valorization of Fig (Ficus carica L.) Waste Leaves: HPLC-QTOF-MS/MS-DPPH System for Online Screening and Identification of Antioxidant Compounds

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