The Therapeutic Action of Colloidal Mercury Sulphide (Hille) and of Other Colloidal Heavy Metal Sulphides in Syphilis Experimentally Produced in Rabbits

Wakerlin, G. E.

doi:10.1001/archderm.1929.02380240013002

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1932

1962

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Cited by 3 publications

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“…1 The drug was also found to be relatively nontoxic for the rabbit, as its maximum tolerated and minimum lethal doses for this species were 30 and 40 mg. per kilogram, respectively.2 In 1931, Freeman, Taylor and White3 reviewed the clinical literature relative to the results obtained up to that time in the treatment of syphilis in man with colloidal mercury sulphide. Previous to their paper, favorable results in two patients with secondary syphilis and twenty-six patients with late, latent and so-called Wassermann-fast syphilis had been reported, with courses varying from 6 to 16 intramuscular or intravenous injections of the drug.…”

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confidence: 98%