“…In a previous paper (Bergmann & Dikstein, 1959) a general equation, describing the movement of solutes in cylindrical tubes, has been derived. By subdividing the tubular system of the kidney into three parts and making certain assumptions about the transfer of water and solutes through the membrane of each individual compartment, we arrived at the conclusion that the best way to study the laws of renal excretion is the use of the 'Dole plot' (Dole, 1943), relating the logarithm of the relative clearance (Rc) of a given solute to the reciprocal urine flow, l/v", according to equation (1):…”