The theoretical substantiation of the composition of a wound-healing ointment with active components of plant origin

Abstract

Aim. To theoretically substantiate the composition of a wound healing ointment with active substances of plant origin for the therapy in the second and third phases of the wound process. Materials and methods. The study object was the generalization and analysis of scientific literature data on the use of medicinal plants in the treatment of the wound process. Results and discussion. Based on the analysis of scientific literature data on the chemical composition and pharmacological properties of medicinal plants used in the treatment of the wound process, the expediency of using the lipophilic extract of marigold flowers, amaranth oil, fennel essential oil as active ingredients in the wound healing ointment has been substantiated. Marigold flowers due to the presence of a large number of carotenoids and flavonoidswill provide a high level of the antimicrobial, reparative action of the ointment. Due to the content of complex biologically active compounds, such as tocopherols, polyunsaturated fatty acids, vitamins, phytosterols and squalene, the amaranth oil has a pronounced antioxidant activity. The components that are part of the essential oil of fennel contributeto the connective tissue growth and the skin restoration, as well as provide a high level of the antifungal action. Conclusions. The analysis of scientific literature data has shown the possibility of using herbal medicines in the treatment of the wound process. The greatest advantage of herbal medicines is the high degree of assimilation of molecules of biologically active substances, which are part of natural compounds as the most physiological form, by skin cells. The expediency of using the lipophilic extract of marigold, amaranth oil and fennel essential oil when developing a wound-healing ointment has been proven. The composition selected will provide the predicted antibacterial, antifungal, antioxidant and reparative effect of the ointment, reduce the likelihood of resistance in pathogenic microorganisms, and accelerate granulation and epithelialization of tissues.

Microbiological studies in the development of wound healing ointment

“…Обраний склад забезпечить прогнозовану антимікробну, протизапальну, антиоксидантну та репаративну дії мазі, зменшить вірогідність виникнення резистентності в патогенних мікроорганізмів, сприятиме прискоренню грануляції та епітелізації тканин [1].…”