The The influence of high doses of α-tocopherol on the content of selected trace elements in the liver of developing chicken embryos in experimentally induced 2,3,7,8-tetrachlorodibenzo-p-dioxin intoxication

Abstract

A chicken embryo develops in ovo without access to a constant circulating maternal nutrient supply, and therefore all necessary nutrients are initially stored in the yolk, and with progressive development are transferred to the liver, where they are taken up in response to various needs. Fluctuations in hepatic trace elements correlate with their mobilization from egg stores. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) intoxication causes liver damage by production of free radicals, while α-tocopherol is a well-known antioxidant and may play a protective role. In the experiment presented here, a solution containing only TCDD, TCDD and α-tocopherol, as well as α-tocopherol exclusively, was administrated into the yolk sac. The iron, zinc, copper and magnesium distribution was evaluated using histological and chemical methods. It has been found that α-tocopherol has no influence on magnesium and zinc content in the liver. The observed increase in iron content may be caused by antagonistic action of iron and α-tocopherol. On the other hand, synergistic action of α-tocopherol and TCDD has been noted with respect to the copper content.

The Improvement of the Adaptation Process of Tocopherol and Acetylsalicylic Acid in Offspring of Mothers Exposed to TCDD

“…Kloser et al [ 17 ] proved that α-tocopherol, in addition to overcoming oxidative stress related to the generation of ROS by dioxins, possesses the blocking properties of an aryl hydrocarbon receptor. Previous studies have shown that when high doses of tocopherol are used in dioxin-contaminated animals, there is a decline in the concentration of diagnostic markers of inflammation and in the results of liver function tests [ 9 , 10 , 18 , 19 ]. In addition, it was found that acetylsalicylic acid (ASA) significantly reduces the amount of TCDD binding to cytosolic AhR, as well as potentially blocking the signal transduction initiated by exposure to the dioxin [ 11 , 20 , 21 , 22 ].…”

Xanthohumol Effect on 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Treated Japanese Quails in Terms of Serum Lipids, Liver Enzymes, Estradiol, and Thyroid Hormones

“…The characteristic feature of dioxins, including TCDD, is stability under all environmental conditions, bioaccumulation and atmospheric or oceanic transport over long distances . The main sources of human and animal exposure to dioxins are food (over 90%) and polluted air. − TCDD is toxic to living organisms and causes, for example, inflammation of tissues and organs.…”