The The Effects of Cinnamaldehyde (Cinnamon Derivatives) and Nystatin on Candida Albicans and Candida Glabrata

Abstract

BACKGROUND: Candida species are the most common opportunistic fungal infections. Today, cinnamon plants have been considered for anti-Candida properties.
 AIM: This study aimed to investigate the effectiveness of cinnamaldehyde extract (from cinnamon derivatives) on Candida albicans and Candida glabrata species and comparison with nystatin.
 MATERIAL AND METHODS: In this study, cinnamaldehyde and nystatin were used. The specimens included Candida albicans and Candida glabrata. Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were measured for each one by the microdilution method. This experiment was repeated three times.
 RESULTS: Cinnamaldehyde extract at a concentration of 62.5 μl/ml was able to prevent the growth of Candida albicans, at a concentration of 93.7 μl/ml, causing Candida albicans to disappear, at 48.8 μl/ml, to prevent the growth of Candida glabrata, and in the concentration of 62.5 μl/ml, causes the loss of Candida glabrata. In comparison, nystatin at 0.5 μg/ml concentration prevented the growth of Candida albicans, at concentrations of 1 μg/ml causing Candida albicans to be destroyed, at 4 μg/ml concentration to prevent the growth of Candida glabrata, and at a concentration of 8 μg/ml causes the loss of Candida glabrata. The results were the same every three times.
 CONCLUSIONS: Although cinnamaldehyde extract had an effect on fungal growth in both Candida albicans and Candida glabrata with a fatal effect; the effect on these two species was lower than nystatin.

Cinnamaldehyde and α-terpineol inhibit the growth of planktonic cultures of Candida albicans and non albicans

“…Research, Society and Development, v. 10, n. 10, e554101019027, 2021 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org /10.33448/rsd-v10i10.19027 Our results are consistent with newly published findings that showed that these molecules were effective at antimicrobial activity against C. albicans and C. Glabrata (Trinh et al, 2011;Dogan et al, 2017;Bakhtiari 2019). However, here we highlight the effectiveness cinnamaldehyde and α-terpineol on inhibiting growth of C. krusei.…”

“…As investigations now point to the antimicrobial effect of cinnamaldehyde and α-terpineol in several reference strains (Dogan et al, 2017., Pootong et al, 2017Bakhtiari et al, 2019), we also investigated antifungal effects in clinical isolated of C. albicans. Although reference strains are widely used in microbiology reports, the evaluation against clinical isolates strains demonstrate a challenge to antifungal drugs due to phenotypic modifications in the cells, which could interfere in the action these drugs (Akers et al, 2015).…”

Effects of Cinnamon (Cinnamomum spp.) in Dentistry: A Review

“…The attention of many researchers has focused on the antimicrobial properties of traditional medical substances, like essential oils (EOs) [ 5 , 6 , 7 ]. EOs and extracts have demonstrated effective antibacterial and antifungal properties [ 8 , 9 , 10 , 11 ]. In the field of dental medicine, oral hygiene products based on herbal extracts are well-known [ 12 , 13 , 14 ].…”

New Insights into the Antimicrobial Action of Cinnamaldehyde towards Escherichia coli and Its Effects on Intestinal Colonization of Mice

“…Cinnamaldehyde has shown a wide spectrum of antimicrobial activity by inhibiting pathogens such as Candida spp. [ 13 , 14 ], E. coli [ 15 ], Listeria monocytogenes [ 16 ], Pseudomonas aeruginosa [ 17 ], and Staphylococcus aureus [ 18 ]. Most of the studies carried out with this compound are related to the food industry, where it is especially used for its antimicrobial properties [ 12 ].…”