The Thalassemias: Models for Analysis of Quantitative Gene Control

A Speculative Comparison of Allotypic Suppression and Allotypic Blast Transformation: Control of Expression of T and B Cell Immunoglobulin Allotypic Markers by a B Cell Product

“…Individual cord blood erythrocytes have the ability to switch from fetal to adult hemoglobin synthesis and may contain both kinds of hemoglobin at the same time; transition from E to y hemoglobin chain synthesis also occurs within single erythroid clones. In addition, A/A sheep rendered mildly anemic have single erythrocytes with both hemoglobins A and C (for review, see Kabat & Koler 1975). Single plasma cells containing more than one immunoglobulin class and myeloma cells producing more than one class of myeloma protein are becoming more frequently identifiied through the use of more sensitive immunofluorescent labelling methods and more precisely defined specific serologic reagents (Asofsky, R., personal communication).…”