The Thalamus and Basal Telencephalon of the Cat. A Cytoarchitectonic Atlas with Stereotaxic Coordinates

Berman, A. L.; Jones, Edward G.

doi:10.1097/00005072-198305000-00008

Cited by 145 publications

(177 citation statements)

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“…There was no indication of a distinct somatotopy with regard to tactile responsive units. Facial tactile fields were found at nearly all recording sites (from approximately A17.5-A15.5, and L5.0-L7.0; Berman and Jones, 1982). Of the neurons tested in the normal condition, 17% (57 of 339) responded to tactile stimulation of the face, 5.4% (15 of 276) responded to auditory stimulation, and 4.5% (8 of 179) had visual responses.…”

Section: Resultsmentioning

confidence: 93%

Response of caudate neurons to stimulation of intrinsic and peripheral afferents in normal, symptomatic, and recovered MPTP-treated cats

Rothblat

Schneider

1993

J. Neurosci.

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Cat caudate nucleus (CD) neurons were tested for changes in spontaneous activity, response to peripheral sensory stimuli (tactile, auditory, and visual), and electrical stimulation of monosynaptic afferents (pericruciate cortex and nucleus centralis lateralis) in normal cats and in the same cats after induction of and spontaneous recovery from parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). After normal baseline data were collected, cats were given MPTP (7.5 mg/kg, 5–7 d) to induce a parkinsonian syndrome consisting of rigidity, akinesia, and decreased orienting to sensory stimuli. During this symptomatic period, the mean spontaneous activity of CD units increased (6.20 spikes/sec vs 2.25 spikes/sec in normal cats). In these same animals, the percentage of units responding to peripheral sensory stimulation was significantly decreased (compared to normal) while the percentage of units responding to electrical stimulation of monosynaptic afferents increased. By 6 weeks after MPTP administration, cats had recovered gross motor and sensorimotor function and CD unit recordings were reinitiated. In functionally recovered animals, all electrophysiological measures returned to levels resembling those seen in normal animals. These data suggest that the processing of peripheral sensory information is an important part of basal ganglia function and that the sensory responsiveness of the CD may reflect the overall motor condition of the animal. The changes observed in the responsiveness of CD neurons to direct electrical stimulation of monosynaptic afferents may indicate that the defect in the processing of polysynaptic sensory information observed in the striatum in parkinsonian animals may be occurring, at least in part, extrastriatally.

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Section: Resultsmentioning

confidence: 93%

Response of caudate neurons to stimulation of intrinsic and peripheral afferents in normal, symptomatic, and recovered MPTP-treated cats

Rothblat

Schneider

1993

J. Neurosci.

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“…Hypocretinergic, MCHergic and MCHergic neurons that displayed Fos immunoreactivity (MCH+ Fos+) were analyzed in two representative coronal sections from each cat at the mammillary (AP 8-9), tuberomammillary (AP 9-10), tuberal (AP 10-11), supraoptic (AP 13-14) and preoptic (AP 14-15) levels of the hypothalamus (according to (Berman and Jones, 1982)). Therefore, the analysis was performed in 10 representative sections, per cat and in 3 to 4 cats, per condition.…”

Section: Histological Data Analysismentioning

confidence: 99%

MCH-containing neurons in the hypothalamus of the cat: Searching for a role in the control of sleep and wakefulness

Torterolo

Sampogna²,

Morales

et al. 2006

Brain Research

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Neurons that utilize melanin-concentrating hormone (MCH) and others that employ hypocretin as neurotransmitter are located in the hypothalamus and project diffusely throughout the CNS, including areas that participate in the generation and maintenance of the states of sleep and wakefulness. In the present report, immunohistochemical methods were employed to examine the distribution of MCHergic and hypocretinergic neurons. In order to test the hypothesis that the MCHergic system is capable of influencing specific behavioral states, we studied Fos immunoreactivity in MCHcontaining neurons during 1) quiet wakefulness, 2) active wakefulness with motor activity, 3) active wakefulness without motor activity, 4) quiet sleep, and, 5) active sleep induced by carbachol (AScarbachol). We determined that MCHergic neuronal somata in the cat are intermingled with hypocretinergic neurons in the dorsal and lateral hypothalamus, principally in the tuberal and tuberomammillary regions; however, hypocretinergic neurons extended more in the anteriorposterior axis than MCHergic neurons. Axosomatic and axodendritic contacts were common between these neurons. In contrast to hypocretinergic neurons, which are known to be active during motor activity and AS-carbachol, Fos immunoreactivity was not observed in MCH-containing neurons in conjunction with any of the preceding behavioral conditions. Non-MCHergic, non-hypocretinergic neurons that expressed c-fos during active wakefulness with motor activity were intermingled with MCH and hypocretin-containing neurons, suggesting that these neurons are related to some aspect of motor function. Further studies are required to elucidate the functional sequela of the interactions between MCHergic and hypocretinergic neurons and the phenotype of the other neurons that were active during motor activity.

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“…13,14 There are also many single-gene disorders in the cat that affect the CNS, making the cat a useful model for diseases that affect human patients. [10][11][12] Our studies show that AAV2/1 was the most efficient at transferring GUSB activity in major gray and white matter structures of the cat brain.…”

Section: Aav In the Cat Brain Ch Vite Et Almentioning

confidence: 99%

“…The cat was chosen for study because: (1) many naturally occurring inherited metabolic disorders affect the cat brain; [10][11][12] (2) the feline nervous system has been well-characterized both anatomically and physiologically; 13,14 (3) the cat brain is approximately 100 times larger than the mouse brain, and (4) the physical organization of the cat brain is more similar to the human brain than is the rodent brain.…”

Section: Introductionmentioning

confidence: 99%

Adeno-associated virus vector-mediated transduction in the cat brain

et al. 2003

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Adeno-associated virus (AAV) vectors are capable of delivering a therapeutic gene to the mouse brain that can result in long-term and widespread protein production. However, the human infant brain is more than 1000 times larger than the mouse brain, which will make the treatment of global neurometabolic disorders in children more difficult. In this study, we evaluated the ability of three AAV serotypes (1,2, and 5) to transduce cells in the cat brain as a model of a large mammalian brain. The human lysosomal enzyme bglucuronidase (GUSB) was used as a reporter gene, because it can be distinguished from feline GUSB by heat stability. The vectors were injected into the cerebral cortex, caudate nucleus, thalamus, corona radiata, internal capsule, and centrum semiovale of 8-week-old cats. The brains were evaluated for gene expression using in situ hybridization and enzyme histochemistry 10 weeks after surgery. The AAV2 vector was capable of transducing cells in the gray matter, while the AAV1 vector resulted in greater transduction of the gray matter than AAV2 as well as transduction of the white matter. AAV5 did not result in detectable transduction in the cat brain.

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The Thalamus and Basal Telencephalon of the Cat. A Cytoarchitectonic Atlas with Stereotaxic Coordinates

Cited by 145 publications

References 0 publications

Response of caudate neurons to stimulation of intrinsic and peripheral afferents in normal, symptomatic, and recovered MPTP-treated cats

Response of caudate neurons to stimulation of intrinsic and peripheral afferents in normal, symptomatic, and recovered MPTP-treated cats

MCH-containing neurons in the hypothalamus of the cat: Searching for a role in the control of sleep and wakefulness

Adeno-associated virus vector-mediated transduction in the cat brain

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