The tetrapeptide N-acetyl-Pro-Pro-Tyr-Leu in skin care formulations—Physicochemical and release studies

Olejnik, Anna; Schroeder, Grzegorz; Nowak, Izabela

doi:10.1016/j.ijpharm.2015.06.050

Cited by 19 publications

(14 citation statements)

References 31 publications

(34 reference statements)

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“…The release of local anaesthetics through the hydrophilic membrane was higher from o/w cream than from w/o cream [57] . Similarly, the release rate of hydrocortisone from o/w cream was two-fold higher than from w/o cream [58] .…”

Section: Comparison Of Release Of Active Substances From Different Tymentioning

confidence: 84%

“…The release rate from hydrophobic and emulsion bases is usually slower than from hydrophilic bases, owing to the partitioning of the active substance between aqueous and oil phase [48] . Examples in Table 2 [ [48][49][50][51][52][53][54][55][56][57][58] show the advantage of the hydrophilic bases over the hydrophobic and emulsion bases in providing the high release rate of active substances.…”

Section: Comparison Of Release Of Active Substances From Different Tymentioning

confidence: 99%

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Dermal and Transdermal Delivery of Active Substances from Semisolid Bases

Jankowski¹,

Dyja²,

Sarecka-Hujar³

2017

pharmaceutical-sciences

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Jankowski, et al.: Dermal and Transdermal Delivery from SemisolidsThe selection of a semisolid base type (hydrophobic, hydrophilic or emulsion) has an essential influence on the skin and transdermal delivery of active substances. The cutaneous and percutaneous absorption may be influenced by interactions occurring between base components and skin on the one hand and interactions between base components and the active ingredient on the other hand. The present article discusses the utility of different types of semisolid bases as carriers of active substances and summarizes results of studies comparing delivery of active substances from different semisolid bases.

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Section: Comparison Of Release Of Active Substances From Different Tymentioning

confidence: 84%

Section: Comparison Of Release Of Active Substances From Different Tymentioning

confidence: 99%

Dermal and Transdermal Delivery of Active Substances from Semisolid Bases

Jankowski¹,

Dyja²,

Sarecka-Hujar³

2017

pharmaceutical-sciences

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“…Semisolids were prepared according to the procedure presented in the previous paper (Olejnik et al 2015a ). Chemical compositions of the formulation are summarized in Table 2 .…”

Section: Methodsmentioning

confidence: 99%

Physico-chemical characterization of formulations containing endomorphin-2 derivatives

et al. 2017

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In this study semisolid formulations containing AcYPFF (N-acetyl-Tyr-Pro-Phe-Phe-NH2) tetrapeptide were obtained and characterized in terms of rheology, stability by multiple light scattering and particle size distribution by laser diffraction. Additionally, the release studies of tetrapeptide from formulations obtained were performed. The influence of different factors such as semisolid and membrane type on tetrapeptide release rate was examined. The release experiments of tetrapeptide modified with palmitoyl group (PalmYPFF) were also carried out. The results proved that formulation type and its rheological properties strongly determined the permeation process of the tetrapeptide. The fastest release of tetrapeptide was observed from hydrogel that had the lowest viscosity. The kinetic data of tetrapeptide released from oil-in-water (o/w) and water-in-oil (w/o) emulsions prepared at elevated temperature showed good fit to the Higuchi equation, whereas when AcYPFF was released from oil-in-water (o/w) emulsion prepared with the addition of auto-emulsifier high linearity with Korsmeyer–Peppas model was observed. While when tetrapeptide was released from Hydrogel the most suitable model was the first-order kinetics. It was suggested that mechanism that led to the release of tetrapeptide from all formulations was non-Fickian diffusion transport. The presence of palmitoyl group changed the solubility of tetrapeptide both in formulation and receptor fluid and thus the release rate of active compound was modified.

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“…Peptides can cause different effects on the skin, but one important hurdle to obtaining effects within the skin is difficulty to penetrate the epidermis [5,6]. Generally, permeation ability depends on different factors: physicochemical properties of the substance (acid dissociation constant (pKa), molecular size, stability, binding affinity, solubility and partition coefficient); the time-scale of permeation; integrity, thickness and components of the skin, cutaneous metabolism; site, area and duration of application; properties of the transdermal device and the creation of a local depot at the site of application [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

A study of the release of active peptide from semisolid hydrogels measured with Franz diffusion apparatus

Łubkowska¹,

Strankowska²,

Maćkiewicz³

et al. 2018

amsa

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Introduction: Recently there has been a growth of interest in novel skin care formulations containing active ingredients, such as low molecular weight peptides. In this paper we present new skincare formulations of hydrogels containing a tetrapeptide (N-Pro-Val-Ala-Gly). Low molecular peptides evolved from research into wound healing and studies on growth stimulation of human skin fibroblasts. The main aim of our study was to perform tests of release of the peptide through synthetic membrane and assessment of the rate of release of peptide from hydrogels from different recipes. Material and methods: The peptide was identified (ion mass, productivity, homogeneity) and the formulations were characterized in terms of physicochemical parameters. Permeation studies were conducted using Franz diffusion cells. The collected samples were subjected to determination by the MALDI-TOF-MS method and the analytical HPLC technique. The ex vivo tests allow for testing of active substances outside a living organism while representing the effects of these compounds on the organism. Results: The results showed that the properties of the formulations strongly determined the release rate of the tetrapeptide. Furthermore, lemon essential oil modified the penetration of the peptide through membranes which we used. Conclusions: The presence of the lemon essential oil in the formulations reduced the time of penetration of the lipophilic peptide.

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The tetrapeptide N-acetyl-Pro-Pro-Tyr-Leu in skin care formulations—Physicochemical and release studies

Cited by 19 publications

References 31 publications

Dermal and Transdermal Delivery of Active Substances from Semisolid Bases

Dermal and Transdermal Delivery of Active Substances from Semisolid Bases

Physico-chemical characterization of formulations containing endomorphin-2 derivatives

A study of the release of active peptide from semisolid hydrogels measured with Franz diffusion apparatus

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