The testicular regression syndrome—do remnants require routine excision?

Bader, Mohammad; Peeraully, Riyad; Ba'ath, M. E.; McPartland, Jo; Baillie, Colin

doi:10.1016/j.jpedsurg.2010.11.018

Cited by 24 publications

(37 citation statements)

References 18 publications

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“…However, there is disagreement regarding the removal of the remnant structures in cases of TRS. These structures were detected in up to 11% of reported cases and among these, cellular atypia was found in up to 26% [4,6]. We found a single case report of malignant transformation of testicular remnants in a cases of TRS [7].…”

Section: Discussionmentioning

confidence: 69%

“…TRS is characterized by partial or total absence of testicular tissue, unilateral or bilateral, with or without rudimentary epididymis and spermatic cord structure in 46XY Surgery Section individual with normal external genitalia [3]. Regarding the aetiology of TRS, the theory of an ischemic event in early or late foetal stage is the most accepted because finding such as dystrophic calcification, hemosiderin deposits and giant cells corroborate this hypothesis [4]. The presence of spermatic cord structure is evidence of the presence of the testis in early intrauterine life.…”

Section: Discussionmentioning

confidence: 99%

“…The laparoscopy is followed by inguinal exploration in cases where spermatic vessels are seen passing through internal inguinal ring [4,5]. The surgical literature regarding TRS emphasizes the importance of identifying the vascular supply and drainage of the gonad.…”

Section: Discussionmentioning

confidence: 99%

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Vanishing Testis Syndrome: Report of Two Cases

Ahmed¹

2014

JCDR

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

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Vanishing Testis Syndrome: Report of Two Cases

Ahmed¹

2014

JCDR

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“…In some cases, such as testicular regression syndrome, testicular tissue is lost antenatally or soon after birth, resulting in complete infertility (48,49). At this point, there are no clear options to salvage reproductive potential for individuals with this condition and other disorders such as complete gonadal dysgenesis.…”

Section: Impaired Fertility Related To Underlying Medical Conditionsmentioning

confidence: 99%

Fertility counseling and preservation: considerations for the pediatric endocrinologist

Saraf

Nahata

2017

Transl. Pediatr

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Infertility is a distressing consequence of numerous pediatric medical conditions and treatments.The field of pediatric fertility preservation has expanded rapidly over the past decade, and clinical guidelines emphasize the importance of discussing infertility risk and fertility preservation options with patients and families in a timely manner. Understanding the various mechanisms and presentations of fertility issues across diagnoses is imperative to provide counseling to patients and families, and identify individuals who may benefit from fertility preservation. The goals of this manuscript are to outline current fertility preservation options in pediatrics, review populations at-risk for infertility that are seen in pediatric endocrinology, and discuss other important issues related to fertility preservation including ethical considerations.

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“…Of these, vanishing testis account for 35-60%. 3 Although the etiologies of vanishing testis remain unclear, some studies have reported that vanishing testis is the result of late antenatal or perinatal vascular thrombosis, torsion or endocrinopathy. [4][5][6] However, cord torsion has not been encountered in testicular nubbin cases, and the vas deferens, epididymis and testicular remnants usually appear hypoplastic.…”

Section: Introductionmentioning

confidence: 99%

Feasible etiology of vanishing testis regarding disturbance of testicular development: Histopathological and immunohistochemical evaluation of testicular nubbins

et al. 2012

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Abbreviations & AcronymsObjectives: To identify the causes of vanishing testis besides vascular events secondary to testicular torsion. Methods: A total of 102 boys with vanishing testis were treated in our hospital from 1984 to 2011. Of these cases, 91 testicular nubbins were excised. Immunohistochemical analysis of testicular nubbins was carried out using anti-Wilms tumor 1 antibody, which is a stable marker of Sertoli cells. Reverse transcription polymerase chain reaction was also carried out using Wilms tumor 1-specific primers. Results: Most testicular nubbins were associated with inguinal lesion (51 patients, 56.0%). Light microscopy showed that 11 patients (12.5%) had seminiferous tubules (with germ cells in three patients [3.4%]), and 77 patients lacked seminiferous tubules, some of which had calcification (26 patients, 29.5%), and/or deposition of hemosiderin (21 patients, 23.9%). Immunohistochemical analysis showed Wilms tumor 1 expression not only in the Sertoli cells of the seminiferous tubules in the seminiferous tubule-positive patients, but also in the interstitium of testicular nubbins in the seminiferous tubulenegative patients. Reverse transcription polymerase chain reaction showed Wilms tumor 1 messenger ribonucleic acid expression in the testicular nubbins of both seminiferous tubule-positive and tubule-negative patients. Conclusions:The presence of Wilms tumor 1-positive cells in the interstitium of vanishing testis lacking seminiferous tubules suggests that the disturbance of testicular development after Sertoli cell differentiation and during testicular tubule formation might be involved in the etiology of vanishing testis.

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The testicular regression syndrome—do remnants require routine excision?

Cited by 24 publications

References 18 publications

Vanishing Testis Syndrome: Report of Two Cases

Vanishing Testis Syndrome: Report of Two Cases

Fertility counseling and preservation: considerations for the pediatric endocrinologist

Feasible etiology of vanishing testis regarding disturbance of testicular development: Histopathological and immunohistochemical evaluation of testicular nubbins

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