The testicular morphology of individuals exposed to dibromochloropropane

Biava, Claude G.; Smuckler, Edward A.; Whorton, Donald

doi:10.1016/0014-4800(78)90085-0

Cited by 66 publications

(16 citation statements)

References 9 publications

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“…cells. No necrotic or inflammatory changes were observed in the seminiferous tubules, merely an absence of spermatogenic activity (107). In humans, the severe oligospermia resulting from DBCP exposure was slowly reversible, requiring 18-21 months following discontinuation of exposure; recovery oc curred histologically and in sperm counts (108).…”

Section: Acetaminophenmentioning

confidence: 98%

The Metabolism of Xenobiotics by Certain Extrahepatic Organs and its Relation to Toxicity*

Gram¹,

Okine²,

Gram³

1986

Annu. Rev. Pharmacol. Toxicol.

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Section: Acetaminophenmentioning

confidence: 98%

The Metabolism of Xenobiotics by Certain Extrahepatic Organs and its Relation to Toxicity*

Gram¹,

Okine²,

Gram³

1986

Annu. Rev. Pharmacol. Toxicol.

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“…It seems therefore that, if spermatozoa were ever to mature in such feminized testes, these would not be able to reach the urogenital pore due to the absence of a vas deferens (52). Indeed, it has been suggested that the inhibition of the proliferation of PGCs during early gonadal development might suppress further spermatogenesis, eventually leading to sterilization (78). Exposures for (3-51, for (3-110, and for 24-110 dph dramatically reduced the number of PGCs in the gonad of fish examined at 110 dph.…”

Section: Effect Of Timing Of Exposure On Formation Of An Oviductmentioning

confidence: 99%

Disruption of Sexual Differentiation in Genetic Male Common Carp (Cyprinus carpio) Exposed to an Alkylphenol during Different Life Stages

Gimeno

Komen

Venderbosch

et al. 1997

Environ. Sci. Technol.

137

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A genetically male population of the common carp, Cyprinus carpio, was exposed to a measured concentration of 0.14 mg/L 4-tert-pentylphenol (TPP) for various periods before and during sexual differentiation in order to determine the presence of a labile period for endocrine disruption. Exposure to TPP for 3 days during the embryo-larval period did not affect the process of sexual differentiation nor the proliferation of the primordial germ cells. Longer exposures, starting before and including sexual differentiation, induced the formation of an oviduct. The oviduct was incomplete or completely closed depending on the timing of the exposure. Once present, this feature was persistent in individuals that were returned to clean water for 59 days. Exposures for various durations before or during sexual differentiation reduced significantly the number of primordial germ cells in a dose-related manner irrespectively of the timing of the exposure. These results demonstrate that the oviduct is a permanent feature that can be used as an end point in a test with male fish for detecting estrogenicity. In addition, they reveal that the period prior to sexual differentiation (24-51 days post hatch) is, besides the period sexual differentiation itself (50-110 days post hatch), sensitive to endocrine disruption, meaning that the duration of exposure of such a test could be reduced to a more narrow labile period.

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“…Recently DBCP has been implicated as the possible cause of sterility in individuals with histories of industrial exposure to this chemical (Whorton et al, 1979;Marshall et al, 1978;Biava et al, 1978;Potashnik et al, 1978). The major effects were azoospermia or oligospermia.…”

mentioning

confidence: 99%

Morphology of nasal-cavity tumours in rats after chronic inhalation of 1,2-dibromo-3-chloropropane

Reznik¹,

Reznik-Schüller²,

Ward³

et al. 1980

Br J Cancer

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Summary.-Groups of 50 F344 rats of each sex were exposed to 0-6 or 3-0 pts/106 of 1,2-dibromo-3-chloropropane (DBCP) by inhalation for 6 h/day, 5 days/week for 103 weeks. Fifty rats of each sex inhaling filtered air were used as unexposed controls. All survivors were killed at 104 weeks. Up to 93 O of the male and female rats developed neoplasms of the nasal cavity. Most of the tumours were adenomas, squamous-cell papillomas, squamous-cell carcinomas, and adenocarcinomas. In the low-dose group 780, of the tumours in males and 66% in females were benign, whereas in the high-dose groups 89% in males and 76% in females were malignant.Invasion through the cribriform plate into the cerebrum or metastasis to the regional lymph nodes was found in 730% of the carcinomas in males and 51% in females.Electron-microscopic examination suggested that the basal cells of the olfactory epithelium were the site of origin of the poorly differentiated adenocarcinomas.

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The testicular morphology of individuals exposed to dibromochloropropane

Cited by 66 publications

References 9 publications

The Metabolism of Xenobiotics by Certain Extrahepatic Organs and its Relation to Toxicity*

The Metabolism of Xenobiotics by Certain Extrahepatic Organs and its Relation to Toxicity*

Disruption of Sexual Differentiation in Genetic Male Common Carp (Cyprinus carpio) Exposed to an Alkylphenol during Different Life Stages

Morphology of nasal-cavity tumours in rats after chronic inhalation of 1,2-dibromo-3-chloropropane

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