The Testicular Descent in Human

Barteczko, Klaus J.; Jacob, M.

doi:10.1007/978-3-642-58353-7

Cited by 14 publications

(10 citation statements)

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“…AMH may also have a role in testicular descent by causing shortening of the gubernacular cord (84). The inguinal canal is formed around the gubernaculum from early fetal life, and enlargement of gubernaculum causes dilatation of the inguinal canal, facilitating later testicular descent (77,85,86). At the end of this phase, the testis is located near the deep inguinal ring.…”

Section: Physiology Of Testicular Descentmentioning

confidence: 99%

Hypogonadism and Cryptorchidism

et al. 2020

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Congenital cryptorchidism (undescended testis) is one of the most common congenital urogenital malformations in boys. Prevalence of cryptorchidism at birth among boys born with normal birth weight ranges from 1.8 to 8.4%. Cryptorchidism is associated with a risk of low semen quality and an increased risk of testicular germ cell tumors. Testicular hormones, androgens and insulin-like peptide 3 (INSL3), have an essential role in the process of testicular descent from intra-abdominal position into the scrotum in fetal life. This explains the increased prevalence of cryptorchidism among boys with diseases or syndromes associated with congenitally decreased secretion or action of androgens, such as patients with congenital hypogonadism and partial androgen insensitivity syndrome. There is evidence to support that cryptorchidism is associated with decreased testicular hormone production later in life. It has been shown that cryptorchidism impairs long-term Sertoli cell function, but may also affect Leydig cells. Germ cell loss taking place in the cryptorchid testis is proportional to the duration of the condition, and therefore early orchiopexy to bring the testis into the scrotum is the standard treatment. However, the evidence for benefits of early orchiopexy for testicular endocrine function is controversial. The hormonal treatments using human chorionic gonadotropin (hCG) or gonadotropin-releasing hormone (GnRH) to induce testicular descent have low success rates, and therefore they are not recommended by the current guidelines for management of cryptorchidism. However, more research is needed to assess the effects of hormonal treatments during infancy on future male reproductive health.

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Section: Physiology Of Testicular Descentmentioning

confidence: 99%

Hypogonadism and Cryptorchidism

et al. 2020

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“…The mesenchyme is essential for the maturation of the ducts and especially for the formation of the vasa deferentia. At this stage, testis and epididymis establish contact with the jelly gubernaculum (Barteczko and Jacob, 2000).…”

Section: Development Of the Epididymismentioning

confidence: 99%

Development, Differentiation and Derivatives of the Wolffian and Müllerian Ducts

Jacob¹,

Yusuf²,

Jacob³

2012

The Human Embryo

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“…After completion of sex determination, both ovary and testis remain in a high pararenal position attached to the body walls by a mesenterial ligamentous complex derived from the mesonephric mesenchyme ( 3,25 ) . At this stage, two major ligaments connect the gonads to the abdominal wall.…”

Section: Environmental Risk Factorsmentioning

confidence: 99%

“…At this stage, two major ligaments connect the gonads to the abdominal wall. First, the cranial mesonephric ligament that develops from the mesentery inserted between the border of the mesonephros and gonad near the hydatid region is connected to the posterior abdominal wall ( 25 ) . Second, the caudal genitoinguinal ligament or the gubernaculum connects the differentiating genital ducts and later the cauda epididymis with the lower abdominal wall at the future position of the inner inguinal ring.…”

Section: Environmental Risk Factorsmentioning

confidence: 99%

Spermatogenesis in Cryptorchidism

Agoulnik

Huang

Ferguson

2011

Methods in Molecular Biology

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Cryptorchidism or undescended testis is the most frequent congenital abnormality in newborn boys. The process of testicular descent to the scrotum is controlled by hormones produced in Leydig cells, insulin-like3, and androgens. Variation in genetic and environmental factors might affect testicular descent. A failure of spermatogenesis and germ cell apoptosis resulting in infertility as well as an increased risk of neoplastic transformation of germ cell are the direct consequences of cryptorchidism in adulthood.

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The Testicular Descent in Human

Cited by 14 publications

References 0 publications

Hypogonadism and Cryptorchidism

Hypogonadism and Cryptorchidism

Development, Differentiation and Derivatives of the Wolffian and Müllerian Ducts

Spermatogenesis in Cryptorchidism

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