The Terminal Stages ofPlasmodium KnowlesiInfection inMacaca Mulatta

Reliable Evidence of Involvement of the Kinin System in Mouse Malaria

“…In the infected mice, systemic arterial pressure was significantly lower than that in the control mice, as reported in monkeys (22,23). The observation may well he a reflection of the pathophysiological role of kinin, which was obviously extracted from blood with consumption of its precursor in plasma.…”

The significance of plasma kinins in malaria

“…The evidence adduced from this work suggests that the peptide kinins contribute to the profound circulatory disturbances earlier reported in the terminal phase of the infection in monkeys (MAEGRAITH et al [6]). The substances are also implicated in the development of tissue lesions in P. knowlesi malaria by increasing capillary wall permeability and inducing stasis and associated local reduction in blood flow in areas such as the brain where the vessels are normally relatively impermeable.…”