The terminal innervation pattern in polymyositis: A histochemical and SFEMG study

Kg, Henriksson; Stålberg, Erik

doi:10.1002/mus.880010103

Cited by 60 publications

(12 citation statements)

References 17 publications

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“…The FD differs for different normal muscles but is of the order of 1P3 to 1P5. From other studies we know that the FD is increased in conditions with reinnervation and in situations of verified fibre type grouping.39 40 fn our total material or patients with MG the FD is increased on average. Statistical analysis has not revealed any correlation with severity or duration of the disease but there is a statistically significant difference between patients treated and not treated with cholinesterase inhibitors.…”

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confidence: 51%

Clinical electrophysiology in myasthenia gravis.

Stålberg¹

1980

Journal of Neurology, Neurosurgery & Psychiatry

128

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confidence: 51%

Clinical electrophysiology in myasthenia gravis.

Stålberg¹

1980

Journal of Neurology, Neurosurgery & Psychiatry

128

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“…4,25 Fiber density was normal to borderline-increased in our patients, similar to previous observations in inflammatory myopathies. 2,4,9 While FD is increased in neurogenic processes, it is typically normal to mildly increased in myopathic disorders. In myopathic remodeling of the MU, increased FD results from such processes as muscle-fiber splitting, musclefiber regeneration, and segmental necrosis with reinnervation.…”

Section: Discussionmentioning

confidence: 99%

Quantitative electrophysiologic studies in sporadic inclusion body myositis

1999

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Sporadic inclusion body myositis (S‐IBM) is a progressive, acquired disease of unknown etiology. Prior studies have suggested neurogenic involvement based on electrophysiologic data, although the biopsy is compatible with a myopathic process. Quantitative electrophysiologic studies were performed in the biceps brachii of 17 subjects with biopsy‐proven S‐IBM. Quantitative motor unit action potential (MUAP) analysis was compatible with myopathy in 16 subjects, with the remaining subject being within normal limits. Quantitative interference pattern was myopathic in all 13 subjects studied. Macro‐EMG MUAP amplitude was reduced in 3 of 17 studies; the remainder were within normal range, and none was increased as would be expected in neurogenic disease. Fiber density was normal to borderline increased in all subjects. Possible reasons for encountering neurogenic‐appearing MUAPs may include choice of muscle studies, because some patients have co‐existing polyneuropathy and large‐amplitude MUAPs from hypertrophied muscle fibers. The data from this study indicate that S‐IBM is a myopathic process. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 480–487, 1999.

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“…Preceding denervation could be caused by segmental necrosis of the muscle fibres.57 Reinnervation in polymyositis is consistent with the fibre type grouping found in biopsied muscles. 7 Significant correlation between nFD and mean jitter in our patients might be due to the early stage of the regenerating activity, when the impulse transmission of the reinnervating complex was still uncertain. The follow-up in two cases is consistent with this hypothesis, because it indicated a large rearrangement of the motor unit (progressive increment in nFD) and more stable transmission of the impulse, perhaps owing to the maturation of the sproutings.…”

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confidence: 73%