The temporal relation between seizure onset and arousal-awakening in temporal lobe seizures

Gümüşyayla, Şadiye; Erdal, Abidin; Tezer, F. İrsel; Saygı, Serap

doi:10.1016/j.seizure.2016.05.005

Cited by 12 publications

(10 citation statements)

References 34 publications

(50 reference statements)

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“…This result is in line with 2 previous scalp EEG studies reporting high rates of awakenings following sleep‐related focal seizures (72% and 65%) 23,24 . Discordant results were found by Gumusyayla et al, with 64% of nocturnal temporal lobe seizures following arousals/awakenings 25 . This discrepancy is likely explained by the limits of scalp EEG for detecting the precise timing of seizure onset in case of focal deep epileptic foci.…”

Section: Discussionsupporting

confidence: 90%

“…23,24 Discordant results were found by Gumusyayla et al, with 64% of nocturnal temporal lobe seizures following arousals/awakenings. 25 This discrepancy is likely explained by the limits of scalp EEG for detecting the precise timing of seizure onset in case of focal deep epileptic foci. Using intracranial EEG, Malow et al found that most nocturnal temporal lobe seizures coincided with or were followed by clinical and scalp EEG arousals.…”

Section: Seizures Disrupt Sleepmentioning

confidence: 99%

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Sleep Disruption in Epilepsy: Ictal and Interictal Epileptic Activity Matter

Peter‐Derex

Klimeš

Latreille

et al. 2020

Annals of Neurology

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Objective: Disturbed sleep is common in epilepsy. The direct influence of nocturnal epileptic activity on sleep fragmentation remains poorly understood. Stereo-electroencephalography paired with polysomnography is the ideal tool to study this relationship. We investigated whether sleep-related epileptic activity is associated with sleep disruption. Methods: We visually marked sleep stages, arousals, seizures, and epileptic bursts in 36 patients with focal drugresistant epilepsy who underwent combined stereo-electroencephalography/polysomnography during presurgical evaluation. Epileptic spikes were detected automatically. Spike and burst indices (n/sec/channel) were computed across four 3-second time windows (baseline sleep, pre-arousal, arousal, and post-arousal). Sleep stage and anatomic localization were tested as modulating factors. We assessed the intra-arousal dynamics of spikes and their relationship with the slow wave component of non-rapid eye-movement sleep (NR) arousals. Results: The vast majority of sleep-related seizures (82.4%; 76.5% asymptomatic) were followed by awakenings or arousals. The epileptic burst index increased significantly before arousals as compared to baseline and postarousal, irrespective of sleep stage or brain area. A similar pre-arousal increase was observed for the spike index in NR stage 2 and rapid eye-movement sleep. In addition, the spike index increased during the arousal itself in neocortical channels, and was strongly correlated with the slow wave component of NR arousals (r = 0.99, p < 0.0001). Interpretation: Sleep fragmentation in focal drug-resistant epilepsy is associated with ictal and interictal epileptic activity. The increase in interictal epileptic activity before arousals suggests its participation in sleep disruption. An additional increase in the spike rate during arousals may result from a sleep-wake boundary instability, suggesting a bidirectional relationship.

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Section: Discussionsupporting

confidence: 90%

Section: Seizures Disrupt Sleepmentioning

confidence: 99%

Sleep Disruption in Epilepsy: Ictal and Interictal Epileptic Activity Matter

Peter‐Derex

Klimeš

Latreille

et al. 2020

Annals of Neurology

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“…Gumusyayla et al [53] investigated the effect of TLE lateralization on the time between epilepsy and awakening. Like Nakamura et al [52], they used retrospective VEEG and PSG data from 33 patients with diagnosed TLE; distinguished between left (19 patients) and right (14 patients).…”

Section: Memorymentioning

confidence: 99%

Bilateral dependence of sleep disorders and temporal lobe epilepsy – literature review

Drabik¹,

Sarnacki²,

Miziak³

2021

Med Og Nauk Zdr.

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Introduction. The analysis of sleep and its phases in the context of various pathophysiologies has attracted increasing attention from the scientific community; therfore, this review of the literature focuses on temporal lobe epilepsy (TLE). Objective. The aim of the review is to systematize and update the knowledge and research currently available on the interplay of sleep deprivation and seizures in TLE, with a focus on MTLE. Materials and method. The following keyword combinations were used to search the Pubmed, Science Direct and Google Scholar databases: sleep disturbance in mesial temporal lobe epilepsy, sleep in temporal lobe epilepsy, nocturnal temporal lobe epilepsy, temporal epilepsy sleep disturbance. After applying exclusion criteria, 23 papers were selected for the review. Brief description of the state of knowledge. The publications qualified for the review were divided into 7 categories in terms of the subject of the publication. These categories relate to characteristic brain waves, memory and its consolidation processes, heart and sleep apnea, anti-epileptic drugs, motor disorders and lateralization of the discharges. Articles that did not fit into any of the previously mentioned categories were placed in the 'Other' group. Conclusions. It is agreed that sleep is an important factor that should be taken into account when selecting the appropriate treatment and researching new AEDs. Moreover, sleep is significant to the patient›s quality of life, has a profound impact on its components, for example, physical and social functions, emotions and leisure, but may also influence the effectiveness of therapy.

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“…17 Time to arousal is shorter for left temporal lobe seizures. 20 The seizure's lobe of origin can also affect sleep characteristics. In a study of patients undergoing inpatient video EEG telemetry, the sleep efficiency index was lower in temporal lobe (0.84) epilepsy patients than it was in those with frontal lobe seizures (0.94), 12 however there were no significant differences in sleep architecture between the temporal and frontal lobe epilepsy patients.…”

mentioning

confidence: 99%

Sleep and Epilepsy

2019

The Causes of Epilepsy

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An epileptic seizure is defined as a transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain. 1 Epilepsy is a chronic neurological condition characterized by recurrent epileptic seizures. 2 Seizures can be focal in onset (with or without secondary generalization) or they can be primarily generalized (i.e., idiopathic). 3,4 Focal onset seizures may either be associated with impaired awareness (complex partial seizures) or without impaired awareness (simple partial seizures). Epilepsy is the fourth most common neurological disorder in the United States, with approximately 150,000 new cases each year. 5 One out of every 26 individuals will develop epilepsy at some point in their lifetime. Thus, epilepsy poses a significant burden on patients, their families, and the health care system. The purpose of this chapter is to review the intricate relationship between sleep and epilepsy, with a special focus on the impact of sleep on seizure timing and frequency. Understanding this relationship is an important step toward successful evaluation and management of patients with epilepsy.

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The temporal relation between seizure onset and arousal-awakening in temporal lobe seizures

Abstract: Video-EEG monitoring and PSG with scalp electrodes in our TLE patients showed that nocturnal seizures mostly followed arousal-awakening, and it was more pronounced in those with left-sided seizures. Arousal-awakening might be a signal for subsequent seizures in patients with TLE.

Cited by 12 publications

References 34 publications

Sleep Disruption in Epilepsy: Ictal and Interictal Epileptic Activity Matter

Sleep Disruption in Epilepsy: Ictal and Interictal Epileptic Activity Matter

Bilateral dependence of sleep disorders and temporal lobe epilepsy – literature review

Sleep and Epilepsy

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