The Temporal Progression of Retinal Degeneration and Early-Stage Idebenone Treatment in the Pde6b rd1/rd1 Mouse Model of Retinal Dystrophy
Lei Zhang,
Wei Liu,
Hai-Yan Wang
et al.
Abstract:Photoreceptor cell death, primarily through apoptosis, related to retinal disorders like retinitis pigmentosa (RP), would result in vision loss. The pathological processes and crucial mutant conditions preceding photoreceptor cell demise are not well understood. This study aims to conduct an in-depth examination of early-stage changes in the widely utilized Pde6brd1/rd1 (rd1) mouse model, which has Pde6b gene mutations representing autosomal recessive RP disorder. We investigated the morphology and ultrastruct… Show more
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