The temporal distribution of new H7N9 avian influenza infections based on laboratory-confirmed cases in Mainland China, 2013–2017

Guo, Zuiyuan; Xiao, Dan; Li, Dongli; Wang, Yayu; Yan, Tiecheng; Dai, Botao; Wang, Xiuhong

doi:10.1038/s41598-018-22410-w

Cited by 10 publications

(10 citation statements)

References 21 publications

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“…The infections caused a total of 623 fatalities (38% case fatality rate) [ 93 , 116 ]. Since 2013, six waves of LPAIV and HPAIV H7N9 were documented ( Table 3 ) [ 92 , 127 ].…”

Section: Evolution and Epidemiology Of Iavmentioning

confidence: 99%

Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview

Mostafa

Mettenleiter

et al. 2018

Viruses

209

221

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Influenza A viruses (IAVs) possess a great zoonotic potential as they are able to infect different avian and mammalian animal hosts, from which they can be transmitted to humans. This is based on the ability of IAV to gradually change their genome by mutation or even reassemble their genome segments during co-infection of the host cell with different IAV strains, resulting in a high genetic diversity. Variants of circulating or newly emerging IAVs continue to trigger global health threats annually for both humans and animals. Here, we provide an introduction on IAVs, highlighting the mechanisms of viral evolution, the host spectrum, and the animal/human interface. Pathogenicity determinants of IAVs in mammals, with special emphasis on newly emerging IAVs with pandemic potential, are discussed. Finally, an overview is provided on various approaches for the prevention of human IAV infections.

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“…The infections caused a total of 623 fatalities (38% case fatality rate) [ 93 , 116 ]. Since 2013, six waves of LPAIV and HPAIV H7N9 were documented ( Table 3 ) [ 92 , 127 ].…”

Section: Evolution and Epidemiology Of Iavmentioning

confidence: 99%

Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview

Mostafa

Mettenleiter

et al. 2018

Viruses

209

221

View full text Add to dashboard Cite

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“…Furthermore, emergence and spread of new high pathogenic influenza variants have posed a critical challenges to the global health and include swine-origin H1N1, H5N8, H9N2, and H7N9 [5][6][7][8] . In China, a novel H7N9 avian influenza virus caused 5 nationwide outbreaks from January 2013 to June 2017 9 . It was estimated that the average risk of fatality associated with H7N9 infection is approximately 40% 10 , which is much higher than that of SARS(11%) 11 .…”

mentioning

confidence: 99%

Antiviral activity of iridoid glycosides extracted from Fructus Gardeniae against influenza A virus by PACT-dependent suppression of viral RNA replication

Guo

Bao

et al. 2020

Sci Rep

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Epidemic and pandemic influenza A virus (IAV) poses a significant threat to human populations worldwide. Iridoid glycosides are principal bioactive components from the Gardenia jasminoides J. Ellis fruit that exhibit antiviral activity against several strains of IAV. In the present study, we evaluated the protective effect of Fructus Gardeniae iridoid glycoside extracts (IGEs) against IAV by cytopathogenic effect(CPE), MTT and a plaque formation assay in vitro and examined the reduction in the pulmonary index (PI), restoration of body weight, reduction in mortality and increases in survival time in vivo.As a host factor, PACT provides protection against the pathogenic influenza A virus by interacting with IAV polymerase and activating the IFN-I response. To verify the whether IGEs suppress IAV replication in a PACT-dependent manner, IAV RNA replication, expression of PACT and the phosphorylation of eIF2α in A549 cells were detected; the levels of IFNβ, PACT and PKR in mouse lung tissues were determined; and the activity of IAV polymerase was evaluated in PACT-compromised cells. The results indicated that IGEs sufficiently alleviated cell damage and suppressed IAV replication in vitro, protecting mice from IAV-induced injury and lethal IAV infection. These anti-IAV effects might be related to disrupted interplay between IVA polymerase and PACT and/or prevention of a PACT-dependent overactivated IFN-I antiviral response. Taken together, our findings reveal a new facet of the mechanisms by which IGEs fight the influenza A virus in a PACT-dependent manner.

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“…Retired individuals are likely to have a higher risk of virus exposure, as the elderly frequently visit LPMs. Indeed, approximately 80% of patients exposed to poultry did so at a LPM, whilst occupational exposure only accounted for approximately 10% of patients [3, 28, 29]. The role of LPMs in the zoonotic spread of H7N9 influenza viruses is further supported by the fact that positive viral samples are most commonly isolated from chickens sold in LPMs [30].…”

Section: Discussionmentioning

confidence: 99%

One health insights to prevent the next HxNy viral outbreak: learning from the epidemiology of H7N9

Zheng

Short

et al. 2019

BMC Infect Dis

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BackgroundWith an increased incidence of viral zoonoses, there is an impetus to strengthen collaborations between public health, agricultural and environmental departments. This interdisciplinary cooperation, also known as the ‘One Health’ approach, has received significant support from various stakeholders. However, current efforts and policies still fall short of those needed for an effective One Health approach towards disease control and prevention. The avian-origin H7N9 influenza A virus outbreak in China serves as an ideal case study to emphasise this point.DiscussionHere, we present the features and epidemiology of human infections with H7N9 influenza virus. At the early stages of the H7N9 epidemic, there was limited virus surveillance and limited prevention measures implemented in live poultry markets. As a result, zoonotic infections with H7N9 influenza viruses continued to enlarge in both numbers and geographic distribution. It was only after the number of human infections with H7N9 influenza virus spiked in the 5th wave of the epidemic that inter-departmental alliances were formed. This resulted in the rapid control of the number of human infections. We therefore further discuss the barriers that prevented the implementation of an effective One Health approach in China and what this means for other emerging, zoonotic viral diseases.SummaryEffective implementation of evidence-based disease management approaches in China will result in substantial health and economic gains. The continual threat of avian influenza, as well as other emerging zoonotic viral infections, emphasizes the need to remove the barriers that prevent the effective implementation of One Health policies in disease management.

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The temporal distribution of new H7N9 avian influenza infections based on laboratory-confirmed cases in Mainland China, 2013–2017

Cited by 10 publications

References 21 publications

Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview

Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview

Antiviral activity of iridoid glycosides extracted from Fructus Gardeniae against influenza A virus by PACT-dependent suppression of viral RNA replication

One health insights to prevent the next HxNy viral outbreak: learning from the epidemiology of H7N9

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