The temporal changes of hemostatic activity in hospitalized patients with COVID-19: a prospective observational study

Abstract

This prospective observational study including 245 patients hospitalized due to COVID-19 confirms that the degree of hypercoagulability, hypofibrinolysis and endothelial dysfunction is associated with the requirement for more advanced respiratory support. These abnormalities are significantly attenuated within 28 days since the admission but inter-group differences persist in the most severely ill patients. This may suggest that endotheliopathy may play more important role in pathogenesis of COVID-19 than abnormalities in coagulation and fibrinolysis. There is not sufficient evidence to support statement that presence of antiphospholipid antibodies is related to severity of COVID-19. Analysis of temporal changes suggests an upward trend in their prevalence and concentration in a 28-day follow-up.