The temporal association between cutaneous T‐cell lymphoma and psoriasis: implications for common biologic processes

Donigan, Jessica M.; Snowden, Caroline; Carter, J.B.; Kimball, Alexa B.

doi:10.1111/jdv.13281

Cited by 10 publications

(20 citation statements)

References 8 publications

(8 reference statements)

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“…The comorbidity of psoriasis and MF has previously been reported . We have already published our experience in this topic in a series of 25 patients, which seems to remain one of the largest cohorts to date .…”

Section: Discussionmentioning

confidence: 92%

The different faces of mycosis fungoides: results of a single‐center study

et al. 2019

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Background Mycosis fungoides (MF) accounts for the majority of cutaneous lymphomas.Apart from the predominant Alibert-Bazin type, several clinicopathological variants of diverse prevalence and biological behavior have been described. Data on clinical and epidemiological aspects of MF clinical subtypes are still weak.Aim To outline the clinical and epidemiological profile of the different MF types in a large volume of Greek patients.Methods Retrospective analysis of 688 MF cases treated in our lymphoma clinic. Epidemiological, clinical, pathological, and immunohistochemical data were retrieved.Results Six-hundred and thirty-six patients (416 males, 220 females) were included. The mean age at diagnosis was 60.2 years; the mean duration of disease prior to diagnosis was 63.2 months. Early-stage MF (I-IIA) involved 475 cases (74.7%). The prevalent type was classical MF (68.5%), followed by folliculotropic (17%), poikilodermic (5.5%), and psoriasiform (4.7%) MF. Atypical MF lesions as the sole manifestation of folliculotropic mycosis fungoides (FMF)alopecia areata-like lesions (n = 10), keratosis pilaris-like lesions (n = 9) or acneiform rash (n = 4)were also observed. Both poikilodermic and folliculotropic subtypes mainly involved younger patients. A significant diagnostic latency concerning poikilodermic and psoriasiform MF cases was recorded. Only 23 (3.3%) cases were of juvenile onset, with classical and poikilodermic MF equally affecting this age group, closely followed by FMF.Conclusions Our study presents the whole clinical-epidemiological spectrum of MF in a large Greek cohort. The high prevalence of atypical MF manifestations characterized by early onset and indolent clinical course stood out among our FMF sample.MF patients followed at the Cutaneous Lymphoma Outpatient

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Section: Discussionmentioning

confidence: 92%

The different faces of mycosis fungoides: results of a single‐center study

et al. 2019

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“…The risk of cancer and specifically lymphomas in patients with psoriasis is a matter of special concern mainly due to the well‐known chronic inflammatory nature of the disease as well as the potential use of immunosuppressants. Recently, Donigan et al . supported the association between MF and psoriasis.…”

Section: Discussionmentioning

confidence: 94%

Psoriasis in patients with mycosis fungoides: a clinicopathological study of 25 patients

Nikolaou

Marinos

Moustou

et al. 2017

Acad Dermatol Venereol

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Our results support the opinion that the association between psoriasis and MF does exist. It is most possibly related to the chronic lymphocyte stimulation that occurs during psoriasis that eventually leads to a dominant clone and the evolution to CTCL. Our study suggests that apart from cases of early MF, which are being indeed misdiagnosed as psoriasis, there is another group of patients, where psoriasis truly coexists with - or even progresses to - MF.

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“…Therefore, many early MF cases are misdiagnosed as psoriasis, whereas another group of cases occur in which the two diseases coexist and/or psoriasis develops into MF. The prevalence of psoriasis among patients with MF was found to be higher than that estimated for the general population (24, 28) and patients with psoriasis have an elevated risk of lymphomas including CTCL (29, 30). In addition to the common symptoms, immunosuppressive agents might also promote MF development in patients with psoriasis (31).…”

Section: Introductionmentioning

confidence: 81%

Next-Generation Sequencing Technologies for Early-Stage Cutaneous T-Cell Lymphoma

Fujii

Kanekura

2019

Front. Med.

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The diagnosis of early stage cutaneous T-cell lymphoma is often difficult, particularly in mycosis fungoides (MF), because the clinical presentation, histological findings, and laboratory findings of MF resemble those of inflammatory skin diseases such as atopic dermatitis, psoriasis, and parapsoriasis en plaque. Furthermore, MF sometimes occurs with or after these inflammatory skin diseases. The current diagnostic criteria heavily rely on clinical impressions along with assessments of T cell clonality. To make a diagnosis of early-stage MF, the detection of a malignant clone is critical. T cell receptor (TCR) gene rearrangements have been detected by southern blotting or polymerase chain reaction for this purpose, but the results of these methods are insufficient. High-throughput TCR sequencing has provided insights into the complexities of the immune repertoire. Accordingly, his technique is more sensitive and specific than current methods, making it useful for the detection of early lesions and monitoring responses to therapy.

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The temporal association between cutaneous T‐cell lymphoma and psoriasis: implications for common biologic processes

Cited by 10 publications

References 8 publications

The different faces of mycosis fungoides: results of a single‐center study

The different faces of mycosis fungoides: results of a single‐center study

Psoriasis in patients with mycosis fungoides: a clinicopathological study of 25 patients

Next-Generation Sequencing Technologies for Early-Stage Cutaneous T-Cell Lymphoma

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