The temperature-sensitive receptors TRPV4 and TRPM8 have important roles in the pruritus of rosacea

Zhou, Xiyuan; Su, Yaoxi; Wu, Shuwei; Wang, Hao; Jiang, Ruotian; Jiang, Xian

doi:10.1016/j.jdermsci.2022.11.004

Cited by 7 publications

(7 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients with rosacea frequently manifest symptoms such as a flushing or a burning sensation, 24 intricately linked to thermal variations. 25 Considering the established role of sleep in thermoregulation in human, 26 Contrary to a previous case series reporting an association between rosacea and obstructive sleep apnea, 15 we did not find any significant relationship with sleep apnea in patients with rosacea.…”

Section: Ta B L E 1 Demographic Characteristicscontrasting

confidence: 97%

“…Patients with rosacea frequently manifest symptoms such as a flushing or a burning sensation, 24 intricately linked to thermal variations 25 . Considering the established role of sleep in thermoregulation in human, 26 perturbations in sleep patterns might precipitate imbalances in thermoregulatory mechanisms, thereby potentiating the onset or exacerbation of rosacea.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Increased risk of sleep disturbances in patients with rosacea: A nationwide population‐based cohort study

Chae,

Cho,

Kim

et al. 2023

The Journal of Dermatology

View full text Add to dashboard Cite

Rosacea is a chronic inflammatory skin disorder linked to various mental disorders, but little is known about the impact of rosacea on sleep disorders. The aim of this study is to confirm the association of rosacea with sleep disorders using a large administrative data set. This nationwide population‐based retrospective cohort study enrolled 1129 individuals with rosacea and 11 017 age‐ and sex‐matched controls without rosacea from the Korean National Health Insurance System database from 2002 to 2015. The prevalence of sleep disorder (7.8%) was significantly higher in patients with rosacea than in controls (5.81%; p < 0.001). Rosacea was associated with an increased risk of sleep disorder (adjusted odds ratio [aOR], 1.287 [95% confidence interval (CI), 1.022–1.623]). Among a variety of sleep disorders, patients with rosacea were likely to have an increased risk of insomnia (aOR, 1.318 [95% CI, 1.002–1.743]). In subgroup analysis, female patients with rosacea (aOR, 1.297 [95% CI, 1.010–1.722]) and those with rosacea and dyslipidemia (aOR, 1.417 [95% CI, 1.062–1.891]) were at a higher risk of having a sleep disorder. Rosacea is associated with an increased risk of having sleep disorders. The management of modifiable risk factors is important for managing sleep disorders in patients with rosacea.

show abstract

Section: Ta B L E 1 Demographic Characteristicscontrasting

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Increased risk of sleep disturbances in patients with rosacea: A nationwide population‐based cohort study

Chae,

Cho,

Kim

et al. 2023

The Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…Moreover, thymol ameliorated pruritus and reversed upregulated proinflammatory cytokines by activating TRPM8, resulting in alleviation of psoriasis‐like skin lesions in an imiquimod‐induced mouse model of psoriasis 20 . In addition, TRPM8 expression is upregulated in the skin and trigeminal ganglia of a mouse model of pruritus‐accompanying LL37‐induced rosacea and in the epidermis of skin biopsy samples from pruritus rosacea patients; these findings suggest TRPM8 is involved in rosacea pruritus 21 . Interestingly, topical application of menthol to healthy volunteers activated TRPM8 and increased cutaneous blood flow not only at the site of application but also across the dermatome 22 .…”

Section: Discussionmentioning

confidence: 91%

“…20 In addition, TRPM8 expression is upregulated in the skin and trigeminal ganglia of a mouse model of pruritus-accompanying LL37-induced rosacea and in the epidermis of skin biopsy samples from pruritus rosacea patients; these findings suggest TRPM8 is involved in rosacea pruritus. 21 Interestingly, topical application of menthol to healthy volunteers activated TRPM8 and increased cutaneous blood flow not only at the site of application but also across the dermatome. 22 In this context, topical activation of peripheral TRPM8 showed neuroprotective effects and mitigated ischemic stroke in mice.…”

Section: Discussionmentioning

confidence: 99%

A randomized, double‐blinded, vehicle‐controlled clinical trial of topical cryosim‐1, a synthetic TRPM8 agonist, in prurigo nodularis

Choi,

Lee,

Jung

et al. 2024

J of Cosmetic Dermatology

View full text Add to dashboard Cite

BackgroundPrurigo nodularis (PN) is an intensively pruritic skin disease that negatively influences quality of life. Cryosim‐1 (Intrinsic IB Spot) is a synthetic, selective transient receptor potential melastatin 8 agonist.AimsTo investigate the efficacy and safety of cryosim‐1 in PN patients.Patients/MethodsA randomized, double‐blinded, placebo‐controlled clinical trial including 30 patients was conducted. The numerical rating scale (NRS) of pruritus was evaluated before and 2 h after cryosim‐1 application at every visit.ResultsAt week 8, the mean pruritus NRS before serum application (4.7 ± 0.4 treatment, 6.1 ± 0.5 placebo; p = 0.045) and 2 h after serum application (2.8 ± 0.4 treatment, 4.3 ± 0.5 placebo; p = 0.031) were significantly lower in the treatment group, and the mean NRS for sleep disorder was significantly lower in the treatment group (2.2 ± 0.5 treatment, 4.2 ± 0.8 placebo; p = 0.031). The mean satisfaction scales for pruritus improvement were significantly higher in the treatment group (7.2 ± 0.6) than in the placebo group (4.0 ± 0.9; p = 0.005). There was no difference in TEWL between the two groups, and no adverse reactions were reported.ConclusionsCryosim‐1 is a safe and effective topical treatment for PN patients.

show abstract

“…Via the influx of cations, TRP channels lead to the release of vasoactive neuropeptides, such as substance P (SP), the peptide linked to the calcitonin gene (CGRP), the activator polypeptide of l pituitary adenylates cyclase (PACAP), the vasoactive intestinal peptide (VIP), or even bradykinin, which is involved in rosacea associated vasodilation, plasma extravasation, and leukocyte recruitment [55]. Moreover, TRP channels mediate pain sensations and itching [56]. Specifically, the activation of TRP ankyrin type 1 (TRPA1) and TRP vanilloid type 1 (TRPV1) lead to a burning sensation and flushing in rosacea patients [57].…”

Section: Vascular Neurovascular and Neuroinflammatory Dysregulationmentioning

confidence: 99%

Advances in the Pathogenesis and Treatment of Rosacea: A Phenotype-Based Therapeutic Approach

Galluccio,

D’Onghia,

Malvaso

et al. 2024

Cosmetics

View full text Add to dashboard Cite

Rosacea is a common chronic inflammatory skin disorder that mainly affects the central face. It is primarily characterized by recurrent episodes of flushing, persistent erythema, inflammatory papules, telangiectasias, phymatous changes, and ocular symptoms. Its pathogenesis is complex and still not completely understood. It encompasses innate and adaptive immune system dysregulation, neurovascular dysfunction, and genetic and environmental factors. To date, four subtypes of rosacea have been identified, based on the predominant clinical features: erythemato-teleangiectatic, papulopustular, pyhomatous, and ocular rosacea. New insights into this condition have led to several pharmacological treatments, including topical medications, spanning from the conventional azelaic acid, metronidazole, benzoyl peroxide, clindamycin, and erythromycin to new ones including not only brimonidine, oxymetazoline, ivermectine, and minocycline but also systemic drugs such as oral antibiotics, isotretinoin, non-selective β-blockers or α2-adrenergic agonists, and laser- or light-based therapies, together with new therapeutic approaches. The aim of this study was to review the current literature on the pathophysiology of rosacea and to provide an overview of therapeutic approaches that specifically address each clinical subtype.

show abstract

The temperature-sensitive receptors TRPV4 and TRPM8 have important roles in the pruritus of rosacea

Cited by 7 publications

References 46 publications

Increased risk of sleep disturbances in patients with rosacea: A nationwide population‐based cohort study

Increased risk of sleep disturbances in patients with rosacea: A nationwide population‐based cohort study

A randomized, double‐blinded, vehicle‐controlled clinical trial of topical cryosim‐1, a synthetic TRPM8 agonist, in prurigo nodularis

Advances in the Pathogenesis and Treatment of Rosacea: A Phenotype-Based Therapeutic Approach

Contact Info

Product

Resources

About